pI: 9.41 |
Length (AA): 477 |
MW (Da): 55384 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 9
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
224 | 303 | 4jq6 (A) | 105 | 195 | 32.00 | 0.014 | 0.12 | 0.268715 | 1.36 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127920)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G12640 | lysophosphatidylcholine acyltransferase 1 |
Arabidopsis thaliana | AT1G63050 | lysophosphatidylcholine acyltransferase |
Brugia malayi | Bm1_34850 | MBOAT family protein |
Brugia malayi | Bm1_34855 | MBOAT family protein |
Candida albicans | CaO19.1881 | similar to S. cerevisiae YOR175C |
Candida albicans | CaO19.9437 | similar to S. cerevisiae YOR175C |
Caenorhabditis elegans | CELE_C08F8.4 | Protein MBOA-4, isoform C |
Caenorhabditis elegans | CELE_C54G7.2 | Protein MBOA-3 |
Caenorhabditis elegans | CELE_ZK550.1 | Protein MBOA-5 |
Dictyostelium discoideum | DDB_G0278541 | membrane bound O-acyl transferase family protein |
Drosophila melanogaster | Dmel_CG18445 | oysgedart |
Echinococcus granulosus | EgrG_000975700 | o acyltransferase membrane bound domain |
Echinococcus granulosus | EgrG_000296000 | o acyltransferase membrane bound domain |
Echinococcus granulosus | EgrG_000724000 | o acyltransferase membrane bound domain |
Entamoeba histolytica | EHI_086180 | membrane-bound O-acyltransferase (MBOAT ) family protein |
Entamoeba histolytica | EHI_103460 | membrane-bound O-acyltransferase (MBOAT ) family protein |
Entamoeba histolytica | EHI_162540 | vacuolar protein sorting 26 |
Echinococcus multilocularis | EmuJ_000296000 | o acyltransferase (membrane bound) domain |
Echinococcus multilocularis | EmuJ_000975700 | o acyltransferase (membrane bound) domain |
Echinococcus multilocularis | EmuJ_000724000 | o acyltransferase (membrane bound) domain |
Homo sapiens | 129642 | membrane bound O-acyltransferase domain containing 2 |
Homo sapiens | 154141 | membrane bound O-acyltransferase domain containing 1 |
Loa Loa (eye worm) | LOAG_15529 | membrane bound O-acyltransferase domain containing 1 |
Loa Loa (eye worm) | LOAG_15679 | hypothetical protein |
Loa Loa (eye worm) | LOAG_11398 | hypothetical protein |
Loa Loa (eye worm) | LOAG_00577 | hypothetical protein |
Loa Loa (eye worm) | LOAG_11396 | hypothetical protein |
Mus musculus | ENSMUSG00000038732 | membrane bound O-acyltransferase domain containing 1 |
Mus musculus | ENSMUSG00000020646 | membrane bound O-acyltransferase domain containing 2 |
Oryza sativa | 4330302 | Os02g0676000 |
Onchocerca volvulus | OVOC2409 |
|
Saccharomyces cerevisiae | YOR175C | Ale1p |
Schistosoma japonicum | Sjp_0108640 | Membrane-bound O-acyltransferase domain-containing protein 2, putative |
Schistosoma japonicum | Sjp_0009460 | Membrane-bound O-acyltransferase domain-containing protein 2, putative |
Schistosoma japonicum | Sjp_0306240 | Membrane-bound O-acyltransferase domain-containing protein 1, putative |
Schistosoma mansoni | Smp_173790 | o-acyltransferase (membrane bound) domain containing protein |
Schistosoma mansoni | Smp_079860.2 | o-acyltransferase (membrane bound) domain containing protein |
Schistosoma mansoni | Smp_079860.1 | o-acyltransferase (membrane bound) domain containing protein |
Schmidtea mediterranea | mk4.011352.01 | MBOAT2 |
Schmidtea mediterranea | mk4.000680.01 | |
Schmidtea mediterranea | mk4.004156.01 | |
Schmidtea mediterranea | mk4.007072.01 | |
Schmidtea mediterranea | mk4.000012.05 | |
Schmidtea mediterranea | mk4.000680.00 | |
Schmidtea mediterranea | mk4.011352.00 | |
Trichomonas vaginalis | TVAG_029540 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_115820 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_446720 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_029550 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_025150 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_313140 | porcupine, putative |
Trichomonas vaginalis | TVAG_110690 | transmembrane protein nessy, putative |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.