Detailed view for Bm1_36115

Basic information

TDR Targets ID: 243514
Brugia malayi, ATPase, AAA family protein
Source Database / ID:  GenBank

pI: 6.8632 | Length (AA): 489 | MW (Da): 54511 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00004   ATPase family associated with various cellular activities (AAA)
PF09336   Vps4 C terminal oligomerisation domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0051013   microtubule severing  
GO:0008568   microtubule-severing ATPase activity  
GO:0017111   nucleoside-triphosphatase activity  
GO:0008017   microtubule binding  
GO:0005524   ATP binding  
GO:0000166   nucleotide binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 77 5lb7 (B) 6 77 18.00 0.000000023 0.76 0.531684 -1.53
15 488 5c19 (D) 273 770 24.00 0.0000021 1 1.14373 0.99
194 482 3b9p (A) 464 749 49.00 0 1 1.1102 -0.3
385 449 2dzn (D) 349 414 20.00 0 0.61 0.389224 -0.37

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128745)

Species Accession Gene Product
Arabidopsis thaliana AT1G80350   ATPase katanin p60
Brugia malayi Bm1_36115   ATPase, AAA family protein
Caenorhabditis elegans CELE_T01G9.5   Protein MEI-1, isoform B
Drosophila melanogaster Dmel_CG10229   Katanin 60
Echinococcus granulosus EgrG_000108700   katanin p60 ATPase containing subunit A1
Echinococcus multilocularis EmuJ_000108700   katanin p60 ATPase containing subunit A1
Giardia lamblia GL50803_15368   Katanin
Homo sapiens ENSG00000102781   katanin p60 subunit A-like 1
Homo sapiens ENSG00000186625   katanin p60 (ATPase containing) subunit A 1
Leishmania braziliensis LbrM.28.0410   katanin, putative,serine peptidase, Clan SJ, family S16, putative
Leishmania donovani LdBPK_280390.1   katanin, putative
Leishmania infantum LinJ.28.0390   katanin, putative,serine peptidase, Clan SJ, family S16, putative
Leishmania major LmjF.28.0400   katanin, putative,serine peptidase, Clan SJ, family S16, putative
Leishmania mexicana LmxM.28.0400   katanin, putative,serine peptidase, Clan SJ, family S16, putative
Loa Loa (eye worm) LOAG_05708   ATPase
Mus musculus ENSMUSG00000019794   katanin p60 (ATPase-containing) subunit A1
Mus musculus 231912   katanin p60 subunit A-like 1
Neospora caninum NCLIV_019140   p60 katanin, putative
Oryza sativa 4324404   Os01g0683100
Schistosoma japonicum Sjp_0208420   ko:K07767 microtubule-severing ATPase [EC3.6.4.3], putative
Schistosoma mansoni Smp_126110   hypothetical protein
Schmidtea mediterranea mk4.002295.02  
Trypanosoma brucei gambiense Tbg972.11.9530   katanin, putative,serine peptidase, Clan SJ, family S16, putative
Trypanosoma brucei gambiense Tbg972.10.1170   katanin, putative
Trypanosoma brucei Tb11.v5.0486   katanin, putative
Trypanosoma brucei Tb927.11.8350   katanin, putative
Trypanosoma brucei Tb927.10.1210   katanin, putative
Trypanosoma congolense TcIL3000_10_1010   katanin, putative
Trypanosoma congolense TcIL3000.11.8890   katanin, putative
Trypanosoma congolense TcIL3000_0_36140   katanin, putative
Trypanosoma cruzi TcCLB.509695.50   katanin, putative
Trypanosoma cruzi TcCLB.509967.70   katanin, putative
Trypanosoma cruzi TcCLB.506163.80   katanin, putative
Toxoplasma gondii TGME49_244590   katanin-like family protein
Trichomonas vaginalis TVAG_498860   AAA ATPase, putative
Trichomonas vaginalis TVAG_028490   AAA ATPase, putative
Trichomonas vaginalis TVAG_245050   AAA ATPase, putative

Essentiality

Bm1_36115 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.1210 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.1210 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.1210 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.1210 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.01.0200 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.0200 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.0200 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.0200 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T01G9.5 Caenorhabditis elegans embryonic lethal wormbase
TGME49_244590 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Bm1_36115 (Brugia malayi), ATPase, AAA family protein
Title for this comment
Comment