Detailed view for Bm1_02495
Basic information
TDR Targets ID: 243550
Brugia malayi, histone H3
Source Database / ID: GenBank
Brugia malayi, histone H3
Source Database / ID: GenBank
pI: 11.8293 |
Length (AA): 136 |
MW (Da): 15370 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
PF00125
Core histone H2A/H2B/H3/H4
Gene Ontology
Mouse over links to read term descriptions.
GO:0046982
protein heterodimerization activity GO:0005634 nucleus
GO:0000786 nucleosome
GO:0003677 DNA binding
GO:0006334 nucleosome assembly
Metabolic Pathways
This gene is not mapped to any metabolic pathway in KEGG.
Structural information
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 2 | 136 | 1kx5 (A) | 1 | 135 | 99.00 | 0 | 1 | 2.00495 | 0.72 |
Help me make sense of these data.
Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
No structure availble in the PDB for this protein
Expression
No expression data available for this gene
Orthologs
Ortholog group members (OG5_126569)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT5G65350 | histone 3 11 |
| Arabidopsis thaliana | AT1G09200 | histone H3 |
| Arabidopsis thaliana | AT4G40030 | Histone H3.3 |
| Arabidopsis thaliana | AT5G65360 | histone H3.1 |
| Arabidopsis thaliana | AT5G10390 | histone H3 |
| Arabidopsis thaliana | AT3G27360 | histone H3 |
| Arabidopsis thaliana | AT5G10400 | histone H3 |
| Arabidopsis thaliana | AT5G10980 | histone H3.3 |
| Arabidopsis thaliana | AT1G75600 | histone H3-like 3 |
| Arabidopsis thaliana | AT4G40040 | histone H3 |
| Babesia bovis | BBOV_I001810 | histone H3, putative |
| Babesia bovis | BBOV_I001860 | histone H3, putative |
| Babesia bovis | BBOV_II001890 | Histone H3, putative |
| Brugia malayi | Bm1_29875 | Histone H3.3 |
| Brugia malayi | Bm1_02495 | histone H3 |
| Candida albicans | CaO19.14083 | Histone H3 similar to S. cerevisiae histone H3 genes HHT1 (YBR010W) and HHT2 (YNL031C) |
| Candida albicans | CaO19.6791 | Histone H3 similar to S. cerevisiae histone H3 genes HHT1 (YBR010W) and HHT2 (YNL031C) |
| Candida albicans | CaO19.8663 | Histone H3 similar to S. cerevisiae histone H3 genes HHT1 (YBR010W) and HHT2 (YNL031C) |
| Candida albicans | CaO19.1061 | Histone H3 similar to S. cerevisiae histone H3 genes HHT1 (YBR010W) and HHT2 (YNL031C) |
| Candida albicans | CaO19.1853 | Histone H3 similar to S. cerevisiae histone H3 genes HHT1 (YBR010W) and HHT2 (YNL031C) |
| Candida albicans | CaO19.9411 | Histone H3 similar to S. cerevisiae histone H3 genes HHT1 (YBR010W) and HHT2 (YNL031C) |
| Caenorhabditis elegans | CELE_F08G2.3 | Protein HIS-42 |
| Caenorhabditis elegans | CELE_F22B3.2 | Protein HIS-63 |
| Caenorhabditis elegans | CELE_F07B7.5 | Protein HIS-49 |
| Caenorhabditis elegans | CELE_W09H1.2 | Protein HIS-73 |
| Caenorhabditis elegans | CELE_B0035.10 | Protein HIS-45 |
| Caenorhabditis elegans | CELE_ZK131.7 | Protein HIS-13 |
| Caenorhabditis elegans | CELE_K06C4.5 | Protein HIS-17 |
| Caenorhabditis elegans | CELE_ZK131.2 | Protein HIS-25 |
| Caenorhabditis elegans | CELE_F54E12.1 | Protein HIS-55 |
| Caenorhabditis elegans | CELE_K03A1.1 | Protein HIS-40 |
| Caenorhabditis elegans | CELE_T10C6.13 | Protein HIS-2 |
| Caenorhabditis elegans | CELE_ZK131.3 | Protein HIS-9 |
| Caenorhabditis elegans | CELE_F45F2.13 | Protein HIS-6 |
| Caenorhabditis elegans | CELE_Y49E10.6 | Protein HIS-72, isoform A |
| Caenorhabditis elegans | CELE_E03A3.3 | Protein HIS-69 |
| Caenorhabditis elegans | CELE_F17E9.10 | Protein HIS-32 |
| Caenorhabditis elegans | CELE_F45E1.6 | Protein HIS-71 |
| Caenorhabditis elegans | CELE_W05B10.1 | Protein HIS-74 |
| Caenorhabditis elegans | CELE_F55G1.2 | Protein HIS-59 |
| Caenorhabditis elegans | CELE_K06C4.13 | Protein HIS-27 |
| Cryptosporidium hominis | Chro.40366 | H3 histone, family 2; histone 2, H3ca1 |
| Cryptosporidium hominis | Chro.30294 | hypothetical protein |
| Cryptosporidium parvum | cgd3_2540 | histone H3 |
| Cryptosporidium parvum | cgd4_3220 | histone H3 |
| Dictyostelium discoideum | DDB_G0271092 | histone H3 |
| Dictyostelium discoideum | DDB_G0270838 | histone H3 |
| Dictyostelium discoideum | DDB_G0267402 | histone H3 |
| Drosophila melanogaster | Dmel_CG33863 | CG33863 gene product from transcript CG33863-RA |
| Drosophila melanogaster | Dmel_CG8989 | Histone H3.3B |
| Drosophila melanogaster | Dmel_CG33851 | CG33851 gene product from transcript CG33851-RA |
| Drosophila melanogaster | Dmel_CG33842 | CG33842 gene product from transcript CG33842-RA |
| Drosophila melanogaster | Dmel_CG33848 | CG33848 gene product from transcript CG33848-RA |
| Drosophila melanogaster | Dmel_CG33854 | CG33854 gene product from transcript CG33854-RA |
| Drosophila melanogaster | Dmel_CG33845 | CG33845 gene product from transcript CG33845-RA |
| Drosophila melanogaster | Dmel_CG33803 | CG33803 gene product from transcript CG33803-RA |
| Drosophila melanogaster | Dmel_CG5825 | Histone H3.3A |
| Drosophila melanogaster | Dmel_CG31613 | CG31613 gene product from transcript CG31613-RA |
| Drosophila melanogaster | Dmel_CG33836 | CG33836 gene product from transcript CG33836-RA |
| Drosophila melanogaster | Dmel_CG33833 | CG33833 gene product from transcript CG33833-RA |
| Drosophila melanogaster | Dmel_CG33809 | CG33809 gene product from transcript CG33809-RA |
| Drosophila melanogaster | Dmel_CG33830 | CG33830 gene product from transcript CG33830-RA |
| Drosophila melanogaster | Dmel_CG33824 | CG33824 gene product from transcript CG33824-RA |
| Drosophila melanogaster | Dmel_CG33812 | CG33812 gene product from transcript CG33812-RA |
| Drosophila melanogaster | Dmel_CG33821 | CG33821 gene product from transcript CG33821-RA |
| Drosophila melanogaster | Dmel_CG33815 | CG33815 gene product from transcript CG33815-RA |
| Drosophila melanogaster | Dmel_CG33806 | CG33806 gene product from transcript CG33806-RA |
| Drosophila melanogaster | Dmel_CG33839 | CG33839 gene product from transcript CG33839-RA |
| Drosophila melanogaster | Dmel_CG33827 | CG33827 gene product from transcript CG33827-RA |
| Drosophila melanogaster | Dmel_CG33860 | CG33860 gene product from transcript CG33860-RA |
| Drosophila melanogaster | Dmel_CG33866 | CG33866 gene product from transcript CG33866-RA |
| Drosophila melanogaster | Dmel_CG33818 | CG33818 gene product from transcript CG33818-RA |
| Drosophila melanogaster | Dmel_CG33857 | CG33857 gene product from transcript CG33857-RA |
| Echinococcus granulosus | EgrG_002016600 | histone |
| Echinococcus granulosus | EgrG_000579800 | expressed protein |
| Entamoeba histolytica | EHI_051840 | histone H3, putative |
| Entamoeba histolytica | EHI_135080 | histone H3, putative |
| Entamoeba histolytica | EHI_193360 | histone H3, putative |
| Entamoeba histolytica | EHI_096650 | histone H3, putative |
| Echinococcus multilocularis | EmuJ_000579800 | expressed protein |
| Giardia lamblia | GL50803_135231 | Histone H3 |
| Giardia lamblia | GL50803_14212 | Histone H3 |
| Homo sapiens | 8357 | histone cluster 1, H3h |
| Homo sapiens | ENSG00000163041 | H3 histone, family 3A |
| Homo sapiens | ENSG00000274750 | histone cluster 1, H3e |
| Homo sapiens | ENSG00000183598 | histone cluster 2, H3d |
| Homo sapiens | ENSG00000278272 | histone cluster 1, H3c |
| Homo sapiens | 333932 | histone cluster 2, H3a |
| Homo sapiens | ENSG00000203814 | histone cluster 2, H2bf |
| Homo sapiens | ENSG00000277775 | histone cluster 1, H3f |
| Homo sapiens | ENSG00000275714 | histone cluster 1, H3a |
| Homo sapiens | ENSG00000132475 | H3 histone, family 3B (H3.3B) |
| Homo sapiens | ENSG00000274267 | histone cluster 1, H3b |
| Homo sapiens | ENSG00000275379 | histone cluster 1, H3i |
| Homo sapiens | 126961 | histone cluster 2, H3c |
| Homo sapiens | ENSG00000197153 | histone cluster 1, H3j |
| Homo sapiens | 8351 | histone cluster 1, H3d |
| Homo sapiens | 8355 | histone cluster 1, H3g |
| Leishmania braziliensis | LbrM.10.1080 | histone H3 |
| Leishmania braziliensis | LbrM.10.1090 | histone H3 |
| Leishmania braziliensis | LbrM.10.0970 | histone H3 |
| Leishmania braziliensis | LbrM.10.1070 | histone H3 |
| Leishmania donovani | LdBPK_100920.1 | histone H3 |
| Leishmania donovani | LdBPK_101070.1 | histone H3 |
| Leishmania infantum | LinJ.16.0600 | histone H3, putative |
| Leishmania infantum | LinJ.10.0920 | histone H3 |
| Leishmania infantum | LinJ.10.1070 | histone H3 |
| Leishmania infantum | LinJ.16.0610 | histone H3, putative |
| Leishmania major | LmjF.10.0870 | histone H3 |
| Leishmania major | LmjF.10.0990 | histone H3 |
| Leishmania major | LmjF.16.0570 | histone H3 |
| Leishmania major | LmjF.16.0575 | histone H3 |
| Leishmania major | LmjF.16.0610 | histone H3, putative |
| Leishmania major | LmjF.16.0600 | histone H3, putative |
| Leishmania mexicana | LmxM.16.0575 | histone H3 |
| Leishmania mexicana | LmxM.10.0870 | histone H3 |
| Leishmania mexicana | LmxM.16.0600 | histone H3, putative |
| Leishmania mexicana | LmxM.16.0610 | histone H3, putative |
| Leishmania mexicana | LmxM.10.0990 | histone H3 |
| Leishmania mexicana | LmxM.16.0570 | histone H3 |
| Leishmania mexicana | LmxM.10.0970 | hypothetical protein, unknown function |
| Loa Loa (eye worm) | LOAG_05159 | H3 histone, family 3A |
| Loa Loa (eye worm) | LOAG_13971 | histone H3 |
| Loa Loa (eye worm) | LOAG_10009 | histone type 2 |
| Mus musculus | 319150 | histone cluster 1, H3b |
| Mus musculus | ENSMUSG00000074403 | histone cluster 2, H3b |
| Mus musculus | ENSMUSG00000060743 | H3 histone, family 3A |
| Mus musculus | ENSMUSG00000081058 | histone cluster 2, H3c2 |
| Mus musculus | ENSMUSG00000069265 | histone cluster 1, H3a |
| Mus musculus | ENSMUSG00000016559 | H3 histone, family 3B |
| Mus musculus | ENSMUSG00000101355 | histone cluster 1, H3h |
| Mus musculus | 319151 | histone cluster 1, H3e |
| Mus musculus | 260423 | histone cluster 1, H3f |
| Mus musculus | 667250 | predicted gene 12657 |
| Mus musculus | 319189 | histone cluster 2, H2bb |
| Mus musculus | 544973 | predicted gene 10257 |
| Mus musculus | 625328 | H3 histone, family 3C |
| Mus musculus | ENSMUSG00000099517 | histone cluster 1, H3g |
| Mus musculus | 319149 | histone cluster 1, H3d |
| Mus musculus | ENSMUSG00000101972 | histone cluster 1, H3i |
| Mus musculus | ENSMUSG00000069310 | histone cluster 1, H3c |
| Mus musculus | ENSMUSG00000093769 | histone cluster 2, H3c1 |
| Neospora caninum | NCLIV_026150 | Histone H3, related |
| Neospora caninum | NCLIV_061960 | Histone H3.3, related |
| Oryza sativa | 4325069 | Os01g0866200 |
| Oryza sativa | 9266481 | Os06g0159750 |
| Oryza sativa | 4349820 | Os11g0155900 |
| Oryza sativa | 4333019 | Os03g0390600 |
| Oryza sativa | 4340006 | Os06g0130900 |
| Oryza sativa | 4338913 | Os05g0438700 |
| Oryza sativa | 4335823 | Os04g0419600 |
| Oryza sativa | 9269345 | Os06g0159501 |
| Oryza sativa | 9271591 | Os06g0160001 |
| Oryza sativa | 4340203 | Os06g0160100 |
| Onchocerca volvulus | OVOC8216 | Histone H3.3 homolog |
| Onchocerca volvulus | OVOC5143 | Histone H3.3 type 1 homolog |
| Onchocerca volvulus | OVOC7891 |
|
| Plasmodium berghei | PBANKA_1117100 | histone H3 variant, putative |
| Plasmodium berghei | PBANKA_0108800 | histone H3, putative |
| Plasmodium falciparum | PF3D7_0610400 | histone H3 |
| Plasmodium falciparum | PF3D7_0617900 | histone H3 variant |
| Plasmodium knowlesi | PKNH_1132500 | histone H3 variant, putative |
| Plasmodium knowlesi | PKNH_1139900 | histone H3, putative |
| Plasmodium vivax | PVX_114020 | histone H3 variant, putative |
| Plasmodium vivax | PVX_113665 | histone H3, putative |
| Plasmodium yoelii | PY00496 | histone 3 |
| Plasmodium yoelii | PY05073 | histone H3 |
| Saccharomyces cerevisiae | YNL031C | histone H3 |
| Saccharomyces cerevisiae | YBR010W | histone H3 |
| Schistosoma japonicum | Sjp_0063120 | Histone H3, putative |
| Schistosoma japonicum | Sjp_0102070 | Histone H3, putative |
| Schistosoma japonicum | Sjp_0079610 | Histone H3.3, putative |
| Schistosoma japonicum | Sjp_0078670 | Histone H3, putative |
| Schistosoma japonicum | Sjp_0121450 | Histone H3.3, putative |
| Schistosoma mansoni | Smp_089860 | histone H3 |
| Schistosoma mansoni | Smp_074610 | histone H3 |
| Schistosoma mansoni | Smp_082240 | histone H3 |
| Schmidtea mediterranea | mk4.018913.00 | |
| Schmidtea mediterranea | mk4.001274.01 | |
| Schmidtea mediterranea | mk4.003160.00 | |
| Schmidtea mediterranea | mk4.001027.00 | Histone H3 |
| Schmidtea mediterranea | mk4.002039.00 | |
| Schmidtea mediterranea | mk4.017017.00 | |
| Schmidtea mediterranea | mk4.009630.00 | |
| Schmidtea mediterranea | mk4.002008.04 | Histone H3 |
| Schmidtea mediterranea | mk4.000688.02 | Histone H3 |
| Schmidtea mediterranea | mk4.003741.00 | |
| Schmidtea mediterranea | mk4.000688.08 | Histone H3 |
| Schmidtea mediterranea | mk4.005767.02 | Histone H3 |
| Schmidtea mediterranea | mk4.003583.00 | Histone H3.3C |
| Schmidtea mediterranea | mk4.006511.01 | |
| Schmidtea mediterranea | mk4.001251.06 | |
| Schmidtea mediterranea | mk4.005509.00 | |
| Schmidtea mediterranea | mk4.000503.06 | |
| Trypanosoma brucei gambiense | Tbg972.1.1520 | histone H3, putative |
| Trypanosoma brucei gambiense | Tbg972.1.1440 | histone H3, putative |
| Trypanosoma brucei gambiense | Tbg972.1.1430 | histone H3, putative |
| Trypanosoma brucei gambiense | Tbg972.1.1450 | histone H3, putative |
| Trypanosoma brucei gambiense | Tbg972.1.1460 | histone H3, putative |
| Trypanosoma brucei gambiense | Tbg972.1.1480 | histone H3, putative |
| Trypanosoma brucei gambiense | Tbg972.1.1420 | histone H3, putative |
| Trypanosoma brucei gambiense | Tbg972.1.1500 | histone H3, putative |
| Trypanosoma brucei | Tb927.1.2450 | histone H3, putative |
| Trypanosoma brucei | Tb927.1.2550 | histone H3, putative |
| Trypanosoma brucei | Tb927.1.2490 | histone H3, putative |
| Trypanosoma brucei | Tb927.1.2530 | histone H3, putative |
| Trypanosoma brucei | Tb927.1.2470 | histone H3, putative |
| Trypanosoma brucei | Tb927.1.2430 | histone H3, putative |
| Trypanosoma brucei | Tb927.1.2510 | histone H3, putative |
| Trypanosoma congolense | TcIL3000_1_1300 | histone H3, putative |
| Trypanosoma congolense | TcIL3000_1_1310 | histone H3, putative |
| Trypanosoma cruzi | TcCLB.509471.59 | histone H3, putative |
| Trypanosoma cruzi | TcCLB.509471.86 | histone H3, putative |
| Trypanosoma cruzi | TcCLB.509471.68 | histone H3, putative |
| Trypanosoma cruzi | TcCLB.505931.50 | histone H3, putative |
| Trypanosoma cruzi | TcCLB.507817.9 | histone H3, putative |
| Trypanosoma cruzi | TcCLB.509471.77 | histone H3, putative |
| Trypanosoma cruzi | TcCLB.509471.95 | histone H3, putative |
| Trypanosoma cruzi | TcCLB.505931.40 | histone H3, putative |
| Trypanosoma cruzi | TcCLB.507817.18 | histone H3, putative |
| Toxoplasma gondii | TGME49_261240 | histone H3 |
| Theileria parva | TP03_0152 | histone H3, putative |
| Theileria parva | TP04_0321 | histone H3, putative |
| Trichomonas vaginalis | TVAG_399370 | centromeric histone H3 htr12, putative |
| Trichomonas vaginalis | TVAG_315320 | centromeric histone H3 htr12, putative |
| Trichomonas vaginalis | TVAG_224650 | histone H3, putative |
| Trichomonas vaginalis | TVAG_445270 | cenpa protein, putative |
| Trichomonas vaginalis | TVAG_087830 | histone H3, putative |
| Trichomonas vaginalis | TVAG_224460 | cenpa protein, putative |
| Trichomonas vaginalis | TVAG_414480 | histone H3, putative |
| Trichomonas vaginalis | TVAG_499020 | histone H3, putative |
| Trichomonas vaginalis | TVAG_085670 | histone H3, putative |
| Trichomonas vaginalis | TVAG_100590 | centromeric histone H3 htr12, putative |
| Trichomonas vaginalis | TVAG_239330 | centromere protein A, putative |
| Trichomonas vaginalis | TVAG_270890 | centromere protein A, putative |
| Trichomonas vaginalis | TVAG_270080 | histone H3, putative |
| Trichomonas vaginalis | TVAG_014910 | histone H3, putative |
| Trichomonas vaginalis | TVAG_137940 | cenpa protein, putative |
| Trichomonas vaginalis | TVAG_341360 | centromeric histone H3 htr12, putative |
| Trichomonas vaginalis | TVAG_497330 | cenpa protein, putative |
| Trichomonas vaginalis | TVAG_129730 | histone H3, putative |
| Trichomonas vaginalis | TVAG_452730 | cenpa protein, putative |
| Trichomonas vaginalis | TVAG_270800 | histone H3, putative |
| Trichomonas vaginalis | TVAG_470690 | cenpa protein, putative |
| Trichomonas vaginalis | TVAG_211260 | histone H3, putative |
Essentiality
Bm1_02495 has one or more orthologs with essentiality data
| Gene/Ortholog | Organism | Phenotype | Source Study |
|---|---|---|---|
| Tb927.1.2430 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
| Tb927.1.2430 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
| Tb927.1.2430 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
| Tb927.1.2430 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
| CELE_T10C6.13 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_T10C6.13 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_T10C6.13 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_T10C6.13 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F45F2.13 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F45F2.13 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F45F2.13 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F45F2.13 | Caenorhabditis elegans | sterile | wormbase |
| CELE_ZK131.3 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_ZK131.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_ZK131.3 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_ZK131.3 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_ZK131.3 | Caenorhabditis elegans | sterile | wormbase |
| CELE_ZK131.7 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_ZK131.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_ZK131.7 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_ZK131.7 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_ZK131.7 | Caenorhabditis elegans | sterile | wormbase |
| CELE_K06C4.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_K06C4.5 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_K06C4.5 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_K06C4.5 | Caenorhabditis elegans | sterile | wormbase |
| CELE_ZK131.2 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_ZK131.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_ZK131.2 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_ZK131.2 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_ZK131.2 | Caenorhabditis elegans | sterile | wormbase |
| CELE_K06C4.13 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_K06C4.13 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_K06C4.13 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_K06C4.13 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_K06C4.13 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F17E9.10 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_F17E9.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F17E9.10 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F17E9.10 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F17E9.10 | Caenorhabditis elegans | sterile | wormbase |
| CELE_K03A1.1 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_K03A1.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_K03A1.1 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_K03A1.1 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_K03A1.1 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F08G2.3 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_F08G2.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F08G2.3 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F08G2.3 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F08G2.3 | Caenorhabditis elegans | sterile | wormbase |
| CELE_B0035.10 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_B0035.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_B0035.10 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_B0035.10 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_B0035.10 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F07B7.5 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_F07B7.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F07B7.5 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F07B7.5 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F07B7.5 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F54E12.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F54E12.1 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F54E12.1 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F55G1.2 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_F55G1.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F55G1.2 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F55G1.2 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F55G1.2 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F22B3.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F22B3.2 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F22B3.2 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F22B3.2 | Caenorhabditis elegans | sterile | wormbase |
| CELE_E03A3.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_E03A3.3 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_E03A3.3 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F45E1.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F45E1.6 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_F45E1.6 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_Y49E10.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_Y49E10.6 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_Y49E10.6 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_Y49E10.6 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_Y49E10.6 | Caenorhabditis elegans | sterile | wormbase |
| CELE_W09H1.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_W09H1.2 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_W05B10.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_W05B10.1 | Caenorhabditis elegans | slow growth | wormbase |
| YNL031C | Saccharomyces cerevisiae | inviable | yeastgenome |
| PBANKA_0108800 | Plasmodium berghei | Essential | plasmo |
| PBANKA_1117100 | Plasmodium berghei | Slow | plasmo |
| TGME49_261240 | Toxoplasma gondii | Probably non-essential | sidik |
| TGME49_261240 | Toxoplasma gondii | Probably essential | sidik |
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nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource -
alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924 -
gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84 -
neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs -
shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan -
blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930 -
yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database -
wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170 -
keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
Phenotypes and Validation (curated)
We have no manually annotated phenotypes for this target.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
No validation data for this target
Associated compounds / Druggability
Known modulators for this target
No chemical compounds associated to this gene
Predicted associations
By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model
Assayability
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
Bibliographic References
No literature references available for this target.
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User comments
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