Detailed view for Bm1_31960

Basic information

TDR Targets ID: 243826
Brugia malayi, GH25683p
Source Database / ID:  GenBank

pI: 10.0612 | Length (AA): 177 | MW (Da): 20286 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05197   TRIC channel

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005261   cation channel activity  
GO:0015672   monovalent inorganic cation transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 177 5egi (A) 8 180 55.00 0 1 1.61105 -0.15
9 177 5eik (A) 10 181 47.00 0 1 1.5624 -0.52

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131081)

Species Accession Gene Product
Brugia malayi Bm1_56230   GH25683p
Brugia malayi Bm1_31960   GH25683p
Caenorhabditis elegans CELE_Y57A10A.28   Protein Y57A10A.28
Caenorhabditis elegans CELE_Y57A10A.10   Protein Y57A10A.10
Drosophila melanogaster Dmel_CG4239   CG4239 gene product from transcript CG4239-RA
Echinococcus granulosus EgrG_000610200   protein of unknown function DUF714
Echinococcus multilocularis EmuJ_000610200   protein of unknown function DUF714
Homo sapiens 79041   transmembrane protein 38A
Homo sapiens ENSG00000095209   transmembrane protein 38B
Loa Loa (eye worm) LOAG_05964   hypothetical protein
Mus musculus ENSMUSG00000028420   transmembrane protein 38B
Mus musculus ENSMUSG00000031791   transmembrane protein 38A
Onchocerca volvulus OVOC9694  
Schistosoma japonicum Sjp_0311140   Trimeric intracellular cation channel type B, putative
Schistosoma japonicum Sjp_0200310   IPR007866,Protein of unknown function DUF714,domain-containing
Schistosoma mansoni Smp_021600   hypothetical protein
Schmidtea mediterranea mk4.000472.03  
Schmidtea mediterranea mk4.000022.06  
Schmidtea mediterranea mk4.002620.04  
Schmidtea mediterranea mk4.002472.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_31960 (Brugia malayi), GH25683p
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