Detailed view for Bm1_51810

Basic information

TDR Targets ID: 243832
Brugia malayi, NLI interacting factor-like phosphatase family protein
Source Database / ID:  GenBank

pI: 8.9748 | Length (AA): 480 | MW (Da): 55397 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03031   NLI interacting factor-like phosphatase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005743   mitochondrial inner membrane  
GO:0005744   mitochondrial inner membrane presequence translocase complex  
GO:0015031   protein transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
243 438 4qqf (A) 162 355 41.00 0 1 0.948933 -0.74
260 426 2ght (A) 79 255 36.00 0 1 0.793317 -1.19
260 428 2q5e (A) 90 268 34.00 0 1 0.766483 -1.08
398 464 5j2l (B) 1 74 27.00 0.58 0.6 0.399183 -0.83

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128978)

Species Accession Gene Product
Arabidopsis thaliana AT1G55900   mitochondrial import inner membrane translocase subunit TIM50
Babesia bovis BBOV_III011630   conserved hypothetical protein
Brugia malayi Bm1_51810   NLI interacting factor-like phosphatase family protein
Candida albicans CaO19.680   similar to S. cerevisiae TIM50 (YPL063W) mitochondrial inner membrane pre-sequence translocase complex guide protein
Candida albicans CaO19.8297   similar to S. cerevisiae TIM50 (YPL063W) mitochondrial inner membrane pre-sequence translocase complex guide protein
Caenorhabditis elegans CELE_T21C9.12   Protein SCPL-4
Cryptosporidium hominis Chro.80393   hypothetical protein
Cryptosporidium parvum cgd8_3400   RNA polymerase II CTD/NL1 interacting protein like phosphatase
Drosophila melanogaster Dmel_CG6691   tiny tim 3
Drosophila melanogaster Dmel_CG2713   tiny tim 50
Echinococcus granulosus EgrG_000466000   mitochondrial import inner membrane translocase
Echinococcus multilocularis EmuJ_000466000   mitochondrial import inner membrane translocase
Homo sapiens ENSG00000105197   translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
Loa Loa (eye worm) LOAG_04917   import inner membrane translocase subunit TIM50
Mus musculus 66525   translocase of inner mitochondrial membrane 50
Neospora caninum NCLIV_015350   hypothetical protein, conserved
Oryza sativa 4339299   Os05g0513200
Oryza sativa 9269938   Os01g0762400
Plasmodium berghei PBANKA_0211000   mitochondrial import inner membrane translocase subunit TIM50, putative
Plasmodium falciparum PF3D7_0726900   mitochondrial import inner membrane translocase subunit TIM50, putative
Plasmodium knowlesi PKNH_0211500   mitochondrial import inner membrane translocase subunit TIM50, putative
Plasmodium vivax PVX_081650   mitochondrial import inner membrane translocase subunit TIM50, putative
Plasmodium yoelii PY02099   Unknown, putative
Saccharomyces cerevisiae YPL063W   Tim50p
Schistosoma japonicum Sjp_0303370   Import inner membrane translocase subunit TIM50-C, mitochondrial precursor, putative
Schistosoma mansoni Smp_024360.1   translocase of inner mitochondrial membrane 50-related
Schistosoma mansoni Smp_024360.2   translocase of inner mitochondrial membrane 50-related
Schmidtea mediterranea mk4.000427.03   Mitochondrial import inner membrane translocase subunit TIM50
Toxoplasma gondii TGME49_283590   NLI interacting factor family phosphatase
Theileria parva TP01_1007   hypothetical protein, conserved

Essentiality

Bm1_51810 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T21C9.12 Caenorhabditis elegans embryonic lethal wormbase
CELE_T21C9.12 Caenorhabditis elegans slow growth wormbase
CELE_T21C9.12 Caenorhabditis elegans sterile wormbase
YPL063W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0211000 Plasmodium berghei Essential plasmo
TGME49_283590 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_51810 (Brugia malayi), NLI interacting factor-like phosphatase family protein
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