Detailed view for Bm1_04255

Basic information

TDR Targets ID: 243888
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 8.2465 | Length (AA): 115 | MW (Da): 13314 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00241   Cofilin/tropomyosin-type actin-binding protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0030837   negative regulation of actin filament polymerization  
GO:0005622   intracellular  
GO:0003779   actin binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 115 2vac (A) 0 119 36.00 0 1 1.52172 -1.63
5 108 2i2q (A) 4 110 29.00 0.0029 0.77 1.17555 -0.2
56 96 3k8p (C) 635 674 40.00 0.52 0.43 0.742722 -0.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129377)

Species Accession Gene Product
Brugia malayi Bm1_04250   hypothetical protein
Brugia malayi Bm1_04255   hypothetical protein
Candida albicans CaO19.2228   Twinfilin A, an actin monomer sequestering protein
Candida albicans CaO19.9770   Twinfilin A, an actin monomer sequestering protein
Caenorhabditis elegans CELE_F38E9.5   Protein F38E9.5
Dictyostelium discoideum DDB_G0274437   A6 family protein kinase
Drosophila melanogaster Dmel_CG3172   twinfilin
Echinococcus granulosus EgrG_000985500   twinfilin 1
Entamoeba histolytica EHI_186770   actin-binding protein, cofilin/tropomyosin family
Echinococcus multilocularis EmuJ_000985500   twinfilin 1
Homo sapiens ENSG00000151239   twinfilin actin-binding protein 1
Homo sapiens ENSG00000247596   twinfilin actin-binding protein 2
Loa Loa (eye worm) LOAG_09474   hypothetical protein
Loa Loa (eye worm) LOAG_09473   hypothetical protein
Mus musculus ENSMUSG00000022451   twinfilin, actin-binding protein, homolog 1 (Drosophila)
Mus musculus ENSMUSG00000023277   twinfilin, actin-binding protein, homolog 2 (Drosophila)
Mus musculus 233637   predicted gene 4887
Onchocerca volvulus OVOC4049  
Saccharomyces cerevisiae YGR080W   Twf1p
Schistosoma japonicum Sjp_0092430   ko:K08870 PTK9 protein tyrosine kinase 9, putative
Schistosoma mansoni Smp_160580   twinfilin
Schmidtea mediterranea mk4.000065.11   Twinfilin
Trichomonas vaginalis TVAG_405170   twinfilin, putative
Trichomonas vaginalis TVAG_238130   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_04255 (Brugia malayi), hypothetical protein
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