Detailed view for Bm1_26610

Basic information

TDR Targets ID: 243890
Brugia malayi, actin-like protein 2
Source Database / ID:  GenBank

pI: 6.5862 | Length (AA): 394 | MW (Da): 45003 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00022   Actin

Gene Ontology

Mouse over links to read term descriptions.
GO:0034314   Arp2/3 complex-mediated actin nucleation  
GO:0007015   actin filament organization  
GO:0005885   Arp2/3 protein complex  
GO:0005856   cytoskeleton  
GO:0005524   ATP binding  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 390 4jd2 (B) 4 388 77.00 0 1 1.92803 -1.03
9 362 2p9i (B) 9 362 83.00 0 1 1.47128 0.5

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128705)

Species Accession Gene Product
Arabidopsis thaliana AT3G27000   actin related protein 2
Brugia malayi Bm1_26610   actin-like protein 2
Candida albicans CaO19.7292   endocytosis and membrane growth and polarity
Caenorhabditis elegans CELE_K07C5.1   Protein ARX-2
Dictyostelium discoideum DDB_G0272106   actin related protein 2
Drosophila melanogaster Dmel_CG9901   Actin-related protein 2
Echinococcus granulosus EgrG_000801400   actin protein 2 B
Entamoeba histolytica EHI_111050   actin-like protein, putative
Echinococcus multilocularis EmuJ_000801400   actin protein 2 B
Homo sapiens ENSG00000138071   ARP2 actin-related protein 2 homolog (yeast)
Leishmania braziliensis LbrM.19.1370   actin-related protein 2, putative
Leishmania donovani LdBPK_191190.1   actin-related protein 2, putative
Leishmania infantum LinJ.19.1190   actin-related protein 2, putative
Leishmania major LmjF.19.1200   actin-related protein 2, putative
Leishmania mexicana LmxM.19.1200   actin-related protein 2, putative
Loa Loa (eye worm) LOAG_11580   hypothetical protein
Mus musculus ENSMUSG00000020152   ARP2 actin-related protein 2
Oryza sativa 4345402   Os08g0369300
Saccharomyces cerevisiae YDL029W   actin-related protein 2
Schistosoma japonicum Sjp_0302640   Actin-related protein 2-A, putative
Schistosoma mansoni Smp_101290.1   hypothetical protein
Schistosoma mansoni Smp_101290.2   hypothetical protein
Schmidtea mediterranea mk4.009143.03  
Schmidtea mediterranea mk4.009585.00   Actin-related protein 2
Trypanosoma brucei gambiense Tbg972.10.19390   actin-like protein 2, putative
Trypanosoma brucei Tb927.10.15800   actin related protein 2, putative
Trypanosoma congolense TcIL3000_10_13610   actin-like protein 2, putative
Trypanosoma cruzi TcCLB.511361.40   actin-related protein 2, putative
Trypanosoma cruzi TcCLB.508899.110   actin-related protein 2, putative
Trichomonas vaginalis TVAG_354040   centractin, putative
Trichomonas vaginalis TVAG_354020   centractin, putative

Essentiality

Bm1_26610 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.15800 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.15800 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.15800 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.15800 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_K07C5.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_K07C5.1 Caenorhabditis elegans larval arrest wormbase
CELE_K07C5.1 Caenorhabditis elegans slow growth wormbase
YDL029W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Xenopus laevis beta-actin 375 aa 47.6% 382 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_26610 (Brugia malayi), actin-like protein 2
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