Detailed view for Bm1_02265

Basic information

TDR Targets ID: 243983
Brugia malayi, MGC69076 protein
Source Database / ID:  GenBank

pI: 6.9096 | Length (AA): 129 | MW (Da): 14925 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04727   ELMO/CED-12 family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005856   cytoskeleton  
GO:0006909   phagocytosis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 56 3hp4 (A) 62 105 39.00 0.51 0.11 0.612137 1.11

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130042)

Species Accession Gene Product
Arabidopsis thaliana AT1G67400   ELMO/CED-12 domain-containing protein
Babesia bovis BBOV_I000780   hypothetical protein
Brugia malayi Bm1_02265   MGC69076 protein
Cryptosporidium hominis Chro.80218   MGC69076 protein
Cryptosporidium parvum cgd8_1890   hypothetical protein
Dictyostelium discoideum DDB_G0280179   engulfment and cell motility ELM family protein
Drosophila melanogaster Dmel_CG10068   CG10068 gene product from transcript CG10068-RA
Echinococcus granulosus EgrG_000805300   ELMO domain containing protein 2
Echinococcus multilocularis EmuJ_000805300   ELMO domain containing protein 2
Homo sapiens ENSG00000179387   ELMO/CED-12 domain containing 2
Homo sapiens ENSG00000110675   ELMO/CED-12 domain containing 1
Loa Loa (eye worm) LOAG_04192   hypothetical protein
Mus musculus ENSMUSG00000035151   ELMO/CED-12 domain containing 2
Mus musculus ENSMUSG00000041986   ELMO/CED-12 domain containing 1
Neospora caninum NCLIV_023270   At2g44770/F16B22.26, related
Oryza sativa 4350523   Os11g0483900
Onchocerca volvulus OVOC2331   Engulfment and cell motility, putative homolog
Schistosoma japonicum Sjp_0314490   ELMO domain-containing protein 2, putative
Schistosoma japonicum Sjp_0206300   ELMO domain-containing protein 2, putative
Schistosoma mansoni Smp_148950   engulfment and cell motility
Schmidtea mediterranea mk4.001204.00  
Toxoplasma gondii TGME49_201120   ELMO/CED-12 family protein
Theileria parva TP02_0847   hypothetical protein

Essentiality

Bm1_02265 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_201120 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_02265 (Brugia malayi), MGC69076 protein
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