Detailed view for Bm1_27275

Basic information

TDR Targets ID: 244000
Brugia malayi, Doublecortin family protein
Source Database / ID:  GenBank

pI: 6.5903 | Length (AA): 574 | MW (Da): 65292 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF03607   Doublecortin

Gene Ontology

Mouse over links to read term descriptions.
GO:0035556   GO:intracellular signal transduction  

GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0007242   intracellular signaling cascade  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 79 5io9 (A) 149 227 53.00 0 1 0.755531 -0.65
70 516 2fo0 (A) 117 529 18.00 0 0.93 0.734646 1.2
102 181 5ip4 (D) 255 334 66.00 0.0000000044 1 0.924273 -1.02
178 533 5kcv (A) 41 438 27.00 0 1 0.551109 1.42

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131156)

Species Accession Gene Product
Brugia malayi Bm1_27275   Doublecortin family protein
Caenorhabditis elegans CELE_Y79H2A.11   Protein ZYG-8
Drosophila melanogaster Dmel_CG17528   CG17528 gene product from transcript CG17528-RD
Homo sapiens ENSG00000170390   doublecortin-like kinase 2
Homo sapiens ENSG00000133083   doublecortin-like kinase 1
Loa Loa (eye worm) LOAG_09649   camk/dcamkl protein kinase
Mus musculus ENSMUSG00000027797   doublecortin-like kinase 1
Mus musculus ENSMUSG00000028078   doublecortin-like kinase 2
Schmidtea mediterranea mk4.001058.03  
Schmidtea mediterranea mk4.000915.05  
Schmidtea mediterranea mk4.001312.06  

Essentiality

Bm1_27275 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y79H2A.11 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens doublecortin-like kinase 2 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 25.5% 349 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0011 1 1
0.0027 1 1
0.0003 0.5 0.5
0.0088 0.4477 0.4477
0.0016 0.5 0.5
0.0008 0.5 0.5
0.0061 0.6883 0.6808
0.0033 0.5 0.5
0.0012 0.5 0.5
0.0063 0.7244 0
0.0059 1 1
0.0039 0.5 0.5
0.0125 0.2589 0.2728
0.0064 0.3377 0.3377
0.0067 0.5 0.5
0.0056 1 1
0.0091 1 1
0.0032 0.5 0.5
0.0062 0.6935 0.7231
0.0092 1 1
0.0036 0.5 0.5
0.0007 0.5 0.5
0.0115 0.3514 0.3514
0.0066 0.3101 0
0.0143 0.3477 0.3477
0.0026 0.5 0.5
0.0007 0.5 0.5
0.0059 1 1
0.0042 0.5 0.5
0.0004 0.5 0.5
0.0029 0.5 0.5
0.0081 0.5 0.5
0.0032 0.5 0.5
0.0037 1 0.5
0.0023 0.5 0.5
0.0059 1 1
0.0039 0.9485 1
0.0098 0.3242 0.2614
0.0022 0.5 0.5
0.0093 0.8828 0
0.0081 1 1
0.0039 0.5 0.5
0.0007 0.5 0.5
0.0016 0.5 0.5
0.0069 0.3067 0.9179
0.0063 1 1
0.0012 0.5 0.5
0.0033 1 1
0.0012 0.5 0.5
0.0143 0.3477 0.3477
0.0018 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_27275 (Brugia malayi), Doublecortin family protein
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