Detailed view for Bm1_12095

Basic information

TDR Targets ID: 244010
Brugia malayi, CES-1
Source Database / ID:  GenBank

pI: 9.9871 | Length (AA): 386 | MW (Da): 43317 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00096   Zinc finger, C2H2 type

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0008270   zinc ion binding  
GO:0003676   nucleic acid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
226 356 5ei9 (F) 720 821 43.00 0 1 0.417678 1.46
282 311 2em6 (A) 13 42 57.00 0.00096 0.81 0.73002 -0.27
305 336 2emk (A) 8 39 47.00 0.0027 0.73 0.667202 -0.67
305 335 2epv (A) 803 833 48.00 0.0071 0.71 0.652611 -0.47
333 379 2eoo (A) 8 45 39.00 0.077 0.49 0.188962 1.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132835)

Species Accession Gene Product
Brugia malayi Bm1_12095   CES-1
Caenorhabditis elegans CELE_F43G9.11   Protein CES-1
Drosophila melanogaster Dmel_CG1130   scratch
Echinococcus granulosus EgrG_000942300   zinc finger protein
Echinococcus granulosus EgrG_000726700   zinc finger C2H2 type
Echinococcus granulosus EgrG_000472200   zinc finger C2H2 type
Echinococcus granulosus EgrG_000726800   zinc finger C2H2 type
Echinococcus multilocularis EmuJ_000472200   zinc finger, C2H2 type
Homo sapiens ENSG00000215397   scratch family zinc finger 2
Homo sapiens ENSG00000261678   scratch family zinc finger 1
Loa Loa (eye worm) LOAG_08890   hypothetical protein
Loa Loa (eye worm) LOAG_08891   hypothetical protein
Mus musculus ENSMUSG00000060257   scratch homolog 2, zinc finger protein (Drosophila)
Mus musculus ENSMUSG00000048385   scratch homolog 1, zinc finger protein (Drosophila)
Schistosoma japonicum Sjp_0100840   ko:K09219 scratch, putative
Schistosoma mansoni Smp_054430   zinc finger protein
Schmidtea mediterranea mk4.000024.04   Putative zinc finger protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_12095 (Brugia malayi), CES-1
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