Detailed view for Bm1_43660

Basic information

TDR Targets ID: 244276
Brugia malayi, Cadherin domain containing protein
Source Database / ID:  GenBank

pI: 4.4734 | Length (AA): 2088 | MW (Da): 234896 | Paralog Number: 3

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00028   Cadherin domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005886   plasma membrane  
GO:0005509   calcium ion binding  
GO:0007156   homophilic cell adhesion  
GO:0007155   cell adhesion  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 391 5t9t (A) 91 507 24.00 0.000000000012 1 0.241945 1.48
27 98 2wbx (A) 20 100 24.00 0.61 0.55 0.206083 -0.42
119 394 4zpo (A) 6 299 33.00 0 1 0.257884 1.17
215 407 3mvs (A) 19 203 37.00 0 1 0.425133 0.5
242 405 4apx (B) 53 232 34.00 0.0018 0.84 0.281244 0.54
871 1424 5szn (A) 47 529 32.00 0 1 0.201026 2.17
917 1033 2yst (A) 3 119 34.00 0 1 0.492134 -0.27
933 1033 2v37 (A) 5 105 27.00 0 0.75 0.397472 -0.35
1759 1823 1zvn (A) 8 71 42.00 0.02 1 0.32083 0.63
1775 1855 2v37 (A) 24 105 36.00 0.00059 1 0.390493 0.11
1788 1946 3ppe (A) 34 203 21.00 0.00095 1 0.215749 0.65

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126716)

Species Accession Gene Product
Brugia malayi Bm1_43665   Cadherin domain containing protein
Brugia malayi Bm1_43660   Cadherin domain containing protein
Brugia malayi Bm1_24010   Cadherin cytoplasmic region family protein
Brugia malayi Bm1_41340   Cadherin domain containing protein
Caenorhabditis elegans CELE_F25F2.2   Protein CDH-4, isoform B
Caenorhabditis elegans CELE_W02B9.1   Protein HMR-1, isoform E
Caenorhabditis elegans CELE_R10F2.1   Protein CDH-1
Drosophila melanogaster Dmel_CG3352   fat
Drosophila melanogaster Dmel_CG7100   Cadherin-N
Drosophila melanogaster Dmel_CG17941   dachsous
Drosophila melanogaster Dmel_CG7749   kugelei
Echinococcus granulosus EgrG_000389000   protocadherin 1
Echinococcus granulosus EgrG_000824500   fat cadherin tumor suppressor
Echinococcus granulosus EgrG_000660400   neural cadherin
Echinococcus granulosus EgrG_000529700   protocadherin gamma b17
Echinococcus multilocularis EmuJ_000824500   fat cadherin tumor suppressor
Echinococcus multilocularis EmuJ_000660400   neural cadherin
Echinococcus multilocularis EmuJ_000390400   protocadherin 1
Echinococcus multilocularis EmuJ_000389000   protocadherin 1
Homo sapiens ENSG00000086570   FAT atypical cadherin 2
Homo sapiens ENSG00000196159   FAT atypical cadherin 4
Homo sapiens ENSG00000166341   dachsous cadherin-related 1
Homo sapiens ENSG00000197410   dachsous cadherin-related 2
Homo sapiens ENSG00000083857   FAT atypical cadherin 1
Homo sapiens ENSG00000107736   cadherin-related 23
Homo sapiens 100653137   cadherin-23-like
Homo sapiens ENSG00000165323   FAT atypical cadherin 3
Loa Loa (eye worm) LOAG_04401   hypothetical protein
Loa Loa (eye worm) LOAG_02440   hypothetical protein
Loa Loa (eye worm) LOAG_15054   hypothetical protein
Loa Loa (eye worm) LOAG_06126   hypothetical protein
Loa Loa (eye worm) LOAG_10844   cadherin domain-containing protein
Loa Loa (eye worm) LOAG_03168   cadherin domain-containing protein
Loa Loa (eye worm) LOAG_10612   hypothetical protein
Loa Loa (eye worm) LOAG_02443   hypothetical protein
Loa Loa (eye worm) LOAG_00836   hypothetical protein
Loa Loa (eye worm) LOAG_03530   hypothetical protein
Loa Loa (eye worm) LOAG_14790   hypothetical protein
Loa Loa (eye worm) LOAG_13920   hypothetical protein
Loa Loa (eye worm) LOAG_08910   hypothetical protein
Loa Loa (eye worm) LOAG_15616   hypothetical protein
Loa Loa (eye worm) LOAG_11272   hypothetical protein
Loa Loa (eye worm) LOAG_12672   hypothetical protein
Loa Loa (eye worm) LOAG_13504   cadherin domain-containing protein
Mus musculus ENSMUSG00000046743   FAT tumor suppressor homolog 4 (Drosophila)
Mus musculus ENSMUSG00000074505   FAT tumor suppressor homolog 3 (Drosophila)
Mus musculus ENSMUSG00000012819   cadherin 23 (otocadherin)
Mus musculus ENSMUSG00000055333   FAT tumor suppressor homolog 2 (Drosophila)
Mus musculus ENSMUSG00000070047   FAT tumor suppressor homolog 1 (Drosophila)
Mus musculus ENSMUSG00000036862   dachsous 1 (Drosophila)
Schistosoma japonicum Sjp_0016180   Protocadherin Fat 1 precursor, putative
Schistosoma japonicum Sjp_0086720   IPR002126,Cadherin,domain-containing
Schistosoma japonicum Sjp_0016170   Protocadherin Fat 3 precursor, putative
Schistosoma japonicum Sjp_0016150   Protocadherin Fat 3 precursor, putative
Schistosoma japonicum Sjp_0053190   Protocadherin-11 X-linked precursor, putative
Schistosoma japonicum Sjp_0016200   Putative fat-like cadherin-related tumor suppressor homolog precursor, putative
Schistosoma japonicum Sjp_0101780   Protocadherin Fat 3 precursor, putative
Schistosoma mansoni Smp_135610   hypothetical protein
Schmidtea mediterranea mk4.000344.10  
Schmidtea mediterranea mk4.013629.01  
Schmidtea mediterranea mk4.005370.01   Protocadherin-like wing polarity protein stan
Schmidtea mediterranea mk4.031066.00  
Schmidtea mediterranea mk4.004966.02  
Schmidtea mediterranea mk4.001792.04   Protocadherin-23
Schmidtea mediterranea mk4.001792.06  
Schmidtea mediterranea mk4.001747.03  
Schmidtea mediterranea mk4.057394.00  
Schmidtea mediterranea mk4.002524.03   Cadherin-4
Schmidtea mediterranea mk4.022628.00   Putative cadherin
Schmidtea mediterranea mk4.001196.06   Protocadherin-16
Schmidtea mediterranea mk4.000909.00  
Schmidtea mediterranea mk4.000378.05  
Schmidtea mediterranea mk4.048920.00  
Schmidtea mediterranea mk4.009780.03  
Schmidtea mediterranea mk4.003784.01  
Schmidtea mediterranea mk4.001196.05  
Schmidtea mediterranea mk4.010655.00  
Schmidtea mediterranea mk4.004966.03  
Schmidtea mediterranea mk4.002273.01  
Schmidtea mediterranea mk4.005370.00   Cadherin-3
Schmidtea mediterranea mk4.001196.07  
Schmidtea mediterranea mk4.005725.00  
Schmidtea mediterranea mk4.000336.07  
Schmidtea mediterranea mk4.034112.00  
Schmidtea mediterranea mk4.009038.00  

Essentiality

Bm1_43660 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_W02B9.1 Caenorhabditis elegans embryonic arrest wormbase
CELE_W02B9.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_W02B9.1 Caenorhabditis elegans larval lethal wormbase
CELE_R10F2.1 Caenorhabditis elegans larval lethal wormbase
CELE_R10F2.1 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Bm1_43660 (Brugia malayi), Cadherin domain containing protein
Title for this comment
Comment