Detailed view for Bm1_54735

Basic information

TDR Targets ID: 244387
Brugia malayi, GH07367p
Source Database / ID:  GenBank

pI: 7.5398 | Length (AA): 232 | MW (Da): 26256 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03959   Serine hydrolase (FSH1)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 217 1ycd (A) 7 232 27.00 0 1 1.21057 -0.82
8 215 1ycd (A) 7 230 31.00 0 1 1.15495 -0.33

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129413)

Species Accession Gene Product
Arabidopsis thaliana AT4G24380   hypothetical protein
Babesia bovis BBOV_IV001210   conserved hypothetical protein
Brugia malayi Bm1_54735   GH07367p
Candida albicans CaO19.3921   dihydrofolate reductase
Candida albicans CaO19.11403   similar to dihydrofolate reductase
Caenorhabditis elegans CELE_C25G4.2   Protein C25G4.2
Dictyostelium discoideum DDB_G0270972   DUF341 family protein
Drosophila melanogaster Dmel_CG5412   CG5412 gene product from transcript CG5412-RA
Echinococcus granulosus EgrG_000339800   ovarian cancer associated gene 2 protein
Echinococcus multilocularis EmuJ_000339800   ovarian cancer associated gene 2 protein
Homo sapiens ENSG00000262664   ovarian tumor suppressor candidate 2
Loa Loa (eye worm) LOAG_02110   hypothetical protein
Mus musculus ENSMUSG00000038268   candidate tumor suppressor in ovarian cancer 2
Oryza sativa 4335994   Os04g0450100
Oryza sativa 4344343   Os07g0687100
Onchocerca volvulus OVOC10220   UPF0483 protein homolog
Saccharomyces cerevisiae YOR280C   Fsh3p
Saccharomyces cerevisiae YMR222C   Fsh2p
Schistosoma japonicum Sjp_0305490   ko:K00287 dihydrofolate reductase [EC1.5.1.3], putative
Schistosoma mansoni Smp_058880   hypothetical protein
Theileria parva TP01_0147   hypothetical protein
Trichomonas vaginalis TVAG_427290   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_54735 (Brugia malayi), GH07367p
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