Detailed view for Bm1_44820

Basic information

TDR Targets ID: 244405
Brugia malayi, Histone acetyltransferase type B catalytic subunit, putative
Source Database / ID:  GenBank

pI: 6.6421 | Length (AA): 447 | MW (Da): 51783 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF10394   Histone acetyl transferase HAT1 N-terminus

Gene Ontology

Mouse over links to read term descriptions.
GO:0042393   histone binding  
GO:0016573   histone acetylation  
GO:0006348   chromatin silencing at telomere  
GO:0006325   establishment and/or maintenance of chromatin architecture  
GO:0005634   nucleus  
GO:0004402   histone acetyltransferase activity  
GO:0016568   chromatin modification  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
40 356 4psw (A) 7 318 24.00 0 1 0.946772 -0.16
42 358 2p0w (A) 23 341 33.00 0 1 1.14117 -0.4

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129384)

Species Accession Gene Product
Arabidopsis thaliana AT5G56740   histone acetyltransferase type B catalytic subunit
Brugia malayi Bm1_44820   Histone acetyltransferase type B catalytic subunit, putative
Candida albicans CaO19.779   histone acetyltransferase
Candida albicans CaO19.8401   histone acetyltransferase
Caenorhabditis elegans CELE_M03C11.4   Protein HAT-1
Dictyostelium discoideum DDB_G0274269   hypothetical protein
Dictyostelium discoideum DDB_G0275159   hypothetical protein
Drosophila melanogaster Dmel_CG2051   CG2051 gene product from transcript CG2051-RB
Echinococcus granulosus EgrG_000223500   histone acetyltransferase type B catalytic
Entamoeba histolytica EHI_073570   histone acetyltransferase, putative
Echinococcus multilocularis EmuJ_000223500   histone acetyltransferase type B catalytic
Homo sapiens ENSG00000128708   histone acetyltransferase 1
Loa Loa (eye worm) LOAG_07191   histone acetyltransferase type B catalytic subunit
Mus musculus ENSMUSG00000027018   histone aminotransferase 1
Oryza sativa 4346812   Os09g0347800
Saccharomyces cerevisiae YPL001W   Hat1p
Schistosoma japonicum Sjp_0059210   ko:K00653 histone acetyltransferase [EC2.3.1.48], putative
Schistosoma mansoni Smp_178700.2   histone acetyltransferase type B catalytic subunit
Schistosoma mansoni Smp_178700.1   histone acetyltransferase type B catalytic subunit
Schmidtea mediterranea mk4.000046.00   Histone acetyltransferase type B catalytic subunit

Essentiality

Bm1_44820 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_M03C11.4 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_44820 (Brugia malayi), Histone acetyltransferase type B catalytic subunit, putative
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