Detailed view for Bm1_56355

Basic information

TDR Targets ID: 244419
Brugia malayi, Tubulin-tyrosine ligase family protein
Source Database / ID:  GenBank

pI: 9.3905 | Length (AA): 695 | MW (Da): 78982 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03133   Tubulin-tyrosine ligase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004835   tubulin-tyrosine ligase activity  
GO:0006464   protein modification process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
16 429 4i50 (F) 6 375 24.00 0 1 0.288483 1.33
60 472 4ylr (A) 41 481 30.00 0 1 0.660545 0.51
60 418 4ylr (A) 41 381 31.00 0 1 0.509347 0.73
112 419 5m7e (F) 60 361 32.00 0.0000000000062 0.86 0.561465 0.5

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128244)

Species Accession Gene Product
Brugia malayi Bm1_09465   Tubulin-tyrosine ligase family protein
Brugia malayi Bm1_56355   Tubulin-tyrosine ligase family protein
Caenorhabditis elegans CELE_ZK1128.6   Protein TTLL-4, isoform B
Caenorhabditis elegans CELE_C55A6.2   Protein TTLL-5, isoform A
Drosophila melanogaster Dmel_CG3964   CG3964 gene product from transcript CG3964-RB
Drosophila melanogaster Dmel_CG16833   CG16833 gene product from transcript CG16833-RM
Drosophila melanogaster Dmel_CG31108   CG31108 gene product from transcript CG31108-RA
Echinococcus granulosus EgrG_000466800   tubulin polyglutamylase TTLL5
Echinococcus granulosus EgrG_000960500   tubulin polyglutamylase ttll4
Echinococcus granulosus EgrG_001051800   tubulin polyglutamylase ttll4
Echinococcus multilocularis EmuJ_000466800   tubulin polyglutamylase TTLL5
Echinococcus multilocularis EmuJ_001051800   tubulin polyglutamylase ttll4
Echinococcus multilocularis EmuJ_000960500   tubulin polyglutamylase ttll4
Homo sapiens ENSG00000135912   tubulin tyrosine ligase-like family, member 4
Homo sapiens ENSG00000119685   tubulin tyrosine ligase-like family, member 5
Leishmania braziliensis LbrM.34.4880   tubulin tyrosine ligase, putative
Leishmania donovani LdBPK_354980.1   tubulin tyrosine ligase, putative
Leishmania infantum LinJ.35.4980   tubulin tyrosine ligase, putative
Leishmania major LmjF.35.4930   tubulin tyrosine ligase, putative
Leishmania mexicana LmxM.34.4930   tubulin tyrosine ligase, putative
Loa Loa (eye worm) LOAG_00072   hypothetical protein
Loa Loa (eye worm) LOAG_09898   tubulin-tyrosine ligase
Mus musculus ENSMUSG00000033257   tubulin tyrosine ligase-like family, member 4
Mus musculus ENSMUSG00000012609   tubulin tyrosine ligase-like family, member 5
Onchocerca volvulus OVOC12929   Tubulin polyglutamylase TTLL5 homolog
Schistosoma japonicum Sjp_0034630   Tubulin polyglutamylase TTLL4, putative
Schistosoma japonicum Sjp_0026430   ko:K06047 Tubulin-tyrosine ligase [EC:6.3.2.25], putative
Schistosoma mansoni Smp_163450   tubulin tyrosine ligase
Schistosoma mansoni Smp_181160   tubulin tyrosine ligase
Schmidtea mediterranea mk4.000018.18   Tubulin polyglutamylase TTLL5
Schmidtea mediterranea mk4.002366.00   Tubulin polyglutamylase TTLL4
Schmidtea mediterranea mk4.024315.00  
Schmidtea mediterranea mk4.000018.19   Tubulin polyglutamylase TTLL5
Schmidtea mediterranea mk4.022977.01   Tubulin polyglutamylase TTLL4
Schmidtea mediterranea mk4.022977.00   Tubulin polyglutamylase TTLL4
Trypanosoma brucei gambiense Tbg972.9.5460   tubulin tyrosine ligase protein, putative
Trypanosoma brucei Tb927.9.9580   tubulin tyrosine ligase protein, putative
Trypanosoma congolense TcIL3000_9_3430   tubulin tyrosine ligase protein, putative
Trypanosoma cruzi TcCLB.510729.150   tubulin tyrosine ligase, putative
Trypanosoma cruzi TcCLB.506885.270   tubulin tyrosine ligase, putative
Trichomonas vaginalis TVAG_426520   conserved hypothetical protein
Trichomonas vaginalis TVAG_170080   conserved hypothetical protein
Trichomonas vaginalis TVAG_407200   conserved hypothetical protein
Trichomonas vaginalis TVAG_026590   conserved hypothetical protein
Trichomonas vaginalis TVAG_308880   conserved hypothetical protein
Trichomonas vaginalis TVAG_445340   conserved hypothetical protein
Trichomonas vaginalis TVAG_161030   conserved hypothetical protein
Trichomonas vaginalis TVAG_362380   conserved hypothetical protein
Trichomonas vaginalis TVAG_431700   conserved hypothetical protein
Trichomonas vaginalis TVAG_202010   conserved hypothetical protein
Trichomonas vaginalis TVAG_268230   conserved hypothetical protein
Trichomonas vaginalis TVAG_016930   conserved hypothetical protein
Trichomonas vaginalis TVAG_150310   conserved hypothetical protein

Essentiality

Bm1_56355 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.1170 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.1170 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.1170 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.1170 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C55A6.2 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_56355 (Brugia malayi), Tubulin-tyrosine ligase family protein
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