Detailed view for Bm1_51655

Basic information

TDR Targets ID: 244481
Brugia malayi, acid phosphatase
Source Database / ID:  GenBank

pI: 8.2013 | Length (AA): 469 | MW (Da): 54546 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00149   Calcineurin-like phosphoesterase
PF14008   Iron/zinc purple acid phosphatase-like protein C
PF16656   Purple acid Phosphatase, N-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  
GO:0003993   acid phosphatase activity  
GO:0046872   metal ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 449 3zk4 (A) 118 572 21.00 0 1 1.0987 0.17
39 453 4kkz (A) 20 428 28.00 0 1 1.11826 -0.31
41 429 4kkz (A) 22 402 31.00 0 1 1.10182 -0.11

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128526)

Species Accession Gene Product
Arabidopsis thaliana AT3G52780   putative purple acid phosphatase 20
Arabidopsis thaliana AT3G20500   purple acid phosphatase 18
Brugia malayi Bm1_51655   acid phosphatase
Caenorhabditis elegans CELE_F21A3.11   Protein F21A3.11
Caenorhabditis elegans CELE_Y105C5B.15   Protein Y105C5B.15
Dictyostelium discoideum DDB_G0282559   N-terminal purple acid phosphatase domain-containing protein
Dictyostelium discoideum DDB_G0268222   hypothetical protein
Dictyostelium discoideum DDB_G0293460   hypothetical protein
Dictyostelium discoideum DDB_G0285351   hypothetical protein
Drosophila melanogaster Dmel_CG1637   CG1637 gene product from transcript CG1637-RC
Echinococcus granulosus EgrG_001169400   iron:zinc purple acid phosphatase protein
Echinococcus multilocularis EmuJ_001169400   iron:zinc purple acid phosphatase protein
Homo sapiens ENSG00000183760   iron/zinc purple acid phosphatase-like protein
Loa Loa (eye worm) LOAG_11184   hypothetical protein
Loa Loa (eye worm) LOAG_13216   hypothetical protein
Mus musculus ENSMUSG00000037469   iron/zinc purple acid phospatase-like
Oryza sativa 4351517   Os12g0151000
Oryza sativa 4333280   Os03g0568900
Oryza sativa 4349796   Os11g0151800
Schistosoma japonicum Sjp_0301970   ko:K01078 acid phosphatase [EC3.1.3.2], putative
Schistosoma mansoni Smp_140610   acid phosphatase-related
Schmidtea mediterranea mk4.004885.00  
Schmidtea mediterranea mk4.010928.00  
Schmidtea mediterranea mk4.000240.03   Acid phosphatase-related
Schmidtea mediterranea mk4.000240.04  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Phaseolus vulgaris Fe(3+)-Zn(2+) purple acid phosphatase 459 aa 28.8% 434 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_51655 (Brugia malayi), acid phosphatase
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