Detailed view for Bm1_14260

Basic information

TDR Targets ID: 244559
Brugia malayi, 40S ribosomal protein S17
Source Database / ID:  GenBank

pI: 10.3458 | Length (AA): 133 | MW (Da): 15457 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00833   Ribosomal S17

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 64 1rq6 (A) 1 62 40.00 0 0.88 1.02987 -0.85
3 127 4kzy (R) 1 123 68.00 0 1 1.68955 -0.09

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126867)

Species Accession Gene Product
Arabidopsis thaliana AT2G05220   40S ribosomal protein S17-2
Arabidopsis thaliana AT3G10610   40S ribosomal protein S17-3
Arabidopsis thaliana AT2G04390   40S ribosomal protein S17-1
Arabidopsis thaliana AT5G04800   40S ribosomal protein S17-4
Babesia bovis BBOV_III001350   40S ribosomal protein S17, putative
Babesia bovis BBOV_III001250   40S ribosomal protein S17, putative
Brugia malayi Bm1_14260   40S ribosomal protein S17
Caenorhabditis elegans CELE_T08B2.10   Protein RPS-17
Cryptosporidium hominis Chro.50481   40S ribosomal protein S17
Cryptosporidium parvum cgd5_3720   40S ribosomal protein S17
Dictyostelium discoideum DDB_G0290141   40S ribosomal protein S17
Drosophila melanogaster Dmel_CG3922   Ribosomal protein S17
Echinococcus granulosus EgrG_001192900   40S ribosomal protein S17
Entamoeba histolytica EHI_135060   ribosomal protein S17, putative
Entamoeba histolytica EHI_009810   ribosomal protein S17, putative
Entamoeba histolytica EHI_037130   ribosomal protein S17, putative
Echinococcus multilocularis EmuJ_001192900   40S ribosomal protein S17
Giardia lamblia GL50803_6135   Ribosomal protein S17
Homo sapiens ENSG00000182774   ribosomal protein S17
Leishmania braziliensis LbrM.28.2760   40S ribosomal protein S17, putative
Leishmania braziliensis LbrM.28.2770   40S ribosomal protein S17, putative
Leishmania donovani LdBPK_282750.1   40S ribosomal protein S17, putative
Leishmania infantum LinJ.28.2760   40S ribosomal protein S17, putative
Leishmania infantum LinJ.28.2750   40S ribosomal protein S17, putative
Leishmania major LmjF.28.2560   40S ribosomal protein S17, putative
Leishmania major LmjF.28.2555   40S ribosomal protein S17, putative
Leishmania mexicana LmxM.28.2555   40S ribosomal protein S17, putative
Leishmania mexicana LmxM.28.2560   40S ribosomal protein S17, putative
Loa Loa (eye worm) LOAG_00534   40S ribosomal protein S17
Mus musculus ENSMUSG00000061787   ribosomal protein S17
Neospora caninum NCLIV_002780   YML024Wp-like protein, related
Oryza sativa 4331346   Os03g0109500
Oryza sativa 4348608   Os10g0411800
Plasmodium berghei PBANKA_1456100   40S ribosomal protein S17, putative
Plasmodium falciparum PF3D7_1242700   40S ribosomal protein S17, putative
Plasmodium knowlesi PKNH_1462000   40S ribosomal protein S17, putative
Plasmodium vivax PVX_101035   40S ribosomal protein S17, putative
Plasmodium yoelii PY04103   Ribosomal S17, putative
Saccharomyces cerevisiae YML024W   ribosomal 40S subunit protein S17A
Saccharomyces cerevisiae YDR447C   ribosomal 40S subunit protein S17B
Schistosoma japonicum Sjp_0213080   ko:K02962 small subunit ribosomal protein S17e, putative
Schistosoma mansoni Smp_055050   40S ribosomal protein S17
Schmidtea mediterranea mk4.000810.13  
Trypanosoma brucei gambiense Tbg972.11.13280   40S ribosomal protein S17, putative
Trypanosoma brucei gambiense Tbg972.11.13290   40S ribosomal protein S17, putative
Trypanosoma brucei Tb927.11.11830   40S ribosomal protein S17, putative
Trypanosoma brucei Tb927.11.11820   40S ribosomal protein S17, putative
Trypanosoma congolense TcIL3000.11.12480   40S ribosomal protein S17, putative
Trypanosoma cruzi TcCLB.508827.70   40S ribosomal protein S17, putative
Trypanosoma cruzi TcCLB.508827.79   40S ribosomal protein S17, putative
Toxoplasma gondii TGME49_207840   ribosomal protein RPS17
Theileria parva TP03_0710   40S ribosomal protein S17, putative
Trichomonas vaginalis TVAG_474010   40S ribosomal protein S17, putative
Trichomonas vaginalis TVAG_258150   40S ribosomal protein S17, putative
Trichomonas vaginalis TVAG_247060   40S ribosomal protein S17, putative
Trichomonas vaginalis TVAG_314730   40S ribosomal protein S17, putative
Trichomonas vaginalis TVAG_453470   40S ribosomal protein S17, putative
Trichomonas vaginalis TVAG_040820   40S ribosomal protein S17, putative
Trichomonas vaginalis TVAG_291460   40S ribosomal protein S17, putative

Essentiality

Bm1_14260 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.3675 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.3675 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.3675 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.3675 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T08B2.10 Caenorhabditis elegans embryonic lethal wormbase
CELE_T08B2.10 Caenorhabditis elegans larval arrest wormbase
CELE_T08B2.10 Caenorhabditis elegans larval lethal wormbase
CELE_T08B2.10 Caenorhabditis elegans slow growth wormbase
CELE_T08B2.10 Caenorhabditis elegans sterile wormbase
TGME49_207840 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_14260 (Brugia malayi), 40S ribosomal protein S17
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