pI: 4.5542 |
Length (AA): 118 |
MW (Da): 12555 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 118 | 4beh (B) | 201 | 315 | 47.00 | 0 | 1 | 1.4102 | 0.93 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126845)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G27710 | 60S acidic ribosomal protein P2-2 |
Arabidopsis thaliana | AT3G44590 | 60S acidic ribosomal protein P2-4 |
Arabidopsis thaliana | AT3G28500 | 60S acidic ribosomal protein P2-3 |
Arabidopsis thaliana | AT5G40040 | 60S acidic ribosomal protein P2-5 |
Arabidopsis thaliana | AT2G27720 | 60S acidic ribosomal protein P2-1 |
Babesia bovis | BBOV_III006260 | 60S acidic ribosomal protein P2 (L12EI) |
Brugia malayi | Bm1_49630 | 60S acidic ribosomal protein P2 |
Brugia malayi | Bm1_39555 | 60s Acidic ribosomal protein |
Candida albicans | CaO19.5928 | cytosolic ribosomal large subunit acidic protein P2B similar to S. cerevisiae RPP2B (YDR382W) |
Candida albicans | CaO19.13349 | cytosolic ribosomal large subunit acidic protein P2B similar to S. cerevisiae RPP2B (YDR382W) |
Caenorhabditis elegans | CELE_Y62E10A.1 | Protein RLA-2 |
Caenorhabditis elegans | CELE_C37A2.7 | Protein C37A2.7 |
Cryptosporidium hominis | Chro.20020 | acidic ribosomal protein P2 |
Cryptosporidium parvum | cgd2_130 | 60S acidic ribosomal protein LP2 |
Dictyostelium discoideum | DDB_G0283393 | 60S acidic ribosomal protein P2 |
Drosophila melanogaster | Dmel_CG4918 | Ribosomal protein LP2 |
Echinococcus granulosus | EgrG_000736400 | 60S acidic ribosomal protein P2 |
Entamoeba histolytica | EHI_186830 | 60S acidic ribosomal protein P2, putative |
Entamoeba histolytica | EHI_179980 | 60S acidic ribosomal protein P2, putative |
Entamoeba histolytica | EHI_138770 | 60S acidic ribosomal protein P2, putative |
Echinococcus multilocularis | EmuJ_000736400 | 60S acidic ribosomal protein P2 |
Giardia lamblia | GL50803_16588 | Hypothetical protein |
Homo sapiens | 6181 | ribosomal protein, large, P2 |
Leishmania braziliensis | LbrM.30.3760 | 60S acidic ribosomal protein P2, putative |
Leishmania braziliensis | LbrM.15.1150 | 60S acidic ribosomal protein P2 |
Leishmania donovani | LdBPK_151190.1 | 60S acidic ribosomal protein P2 |
Leishmania donovani | LdBPK_151200.1 | 60S acidic ribosomal protein P2 |
Leishmania donovani | LdBPK_303780.1 | 60S acidic ribosomal protein P2, putative |
Leishmania infantum | LinJ.30.3790 | 60S acidic ribosomal protein P2, putative |
Leishmania infantum | LinJ.15.1200 | 60S acidic ribosomal protein P2 |
Leishmania infantum | LinJ.30.3780 | 60S acidic ribosomal protein P2, putative |
Leishmania infantum | LinJ.15.1190 | 60S acidic ribosomal protein P2 |
Leishmania major | LmjF.30.3730 | 60S acidic ribosomal protein P2, putative |
Leishmania major | LmjF.30.3720 | 60S acidic ribosomal protein P2, putative |
Leishmania major | LmjF.15.1203 | 60S acidic ribosomal protein P2 |
Leishmania major | LmjF.15.1207 | 60S acidic ribosomal protein P2 |
Leishmania mexicana | LmxM.29.3730 | 60S acidic ribosomal protein P2, putative |
Leishmania mexicana | LmxM.29.3720 | 60S acidic ribosomal protein P2, putative |
Leishmania mexicana | LmxM.15.1203 | 60S acidic ribosomal protein P2 |
Leishmania mexicana | LmxM.15.1207 | 60S acidic ribosomal protein P2 |
Loa Loa (eye worm) | LOAG_12589 | 60S acidic ribosomal protein |
Loa Loa (eye worm) | LOAG_11144 | hypothetical protein |
Mus musculus | ENSMUSG00000025508 | ribosomal protein, large P2 |
Neospora caninum | NCLIV_053940 | 60S acidic ribosomal protein P2, related |
Oryza sativa | 4329540 | Os02g0529700 |
Oryza sativa | 4338938 | Os05g0445500 |
Oryza sativa | 4326782 | Os01g0191100 |
Oryza sativa | 9268174 | Os07g0251301 |
Onchocerca volvulus | OVOC727 | 60S acidic ribosomal protein P2 homolog |
Plasmodium berghei | PBANKA_0407700 | 60S acidic ribosomal protein P2, putative |
Plasmodium falciparum | PF3D7_0309600 | 60S acidic ribosomal protein P2 |
Plasmodium knowlesi | PKNH_0833100 | 60S acidic ribosomal protein P2, putative |
Plasmodium vivax | PVX_119587 | 60S acidic ribosomal protein P2, putative |
Plasmodium yoelii | PY02905 | 60S acidic ribosomal protein P2 |
Saccharomyces cerevisiae | YDR382W | ribosomal protein P2B |
Saccharomyces cerevisiae | YOL039W | ribosomal protein P2A |
Schistosoma japonicum | Sjp_0217340 | ko:K02943 large subunit ribosomal protein LP2, putative |
Schistosoma mansoni | Smp_029820 | 60S ribosomal protein P2 |
Schmidtea mediterranea | mk4.000762.01 | Putative 60s acidic ribosomal protein P2 |
Trypanosoma brucei gambiense | Tbg972.6.4920 | 60S acidic ribosomal protein P2, putative |
Trypanosoma brucei gambiense | Tbg972.9.3010 | 60S acidic ribosomal protein, putative |
Trypanosoma brucei gambiense | Tbg972.6.4930 | 60S acidic ribosomal protein P2, putative |
Trypanosoma brucei | Tb927.6.5130 | 60S acidic ribosomal protein P2, putative |
Trypanosoma brucei | Tb927.6.5120 | 60S acidic ribosomal protein P2, putative |
Trypanosoma brucei | Tb927.9.5690 | 60S acidic ribosomal protein, putative |
Trypanosoma congolense | TcIL3000_9_1910 | 60S acidic ribosomal protein, putative |
Trypanosoma congolense | TcIL3000_6_4580 | 60S acidic ribosomal protein P2, putative |
Trypanosoma cruzi | TcCLB.506595.100 | 60S acidic ribosomal protein P2, putative |
Trypanosoma cruzi | TcCLB.509165.40 | 60S acidic ribosomal protein P2 beta (H6.4), putative |
Trypanosoma cruzi | TcCLB.505977.26 | 60S acidic ribosomal protein P2, putative |
Trypanosoma cruzi | TcCLB.510643.140 | 60S acidic ribosomal protein P2, putative |
Toxoplasma gondii | TGME49_309810 | ribosomal protein RPP2 |
Theileria parva | TP02_0370 | 60S acidic ribosomal protein P2, putative |
Trichomonas vaginalis | TVAG_464040 | 60S acidic ribosomal protein P2, putative |
Trichomonas vaginalis | TVAG_499760 | 60S acidic ribosomal protein P2, putative |
Trichomonas vaginalis | TVAG_220300 | 60S acidic ribosomal protein P2, putative |
Trichomonas vaginalis | TVAG_411440 | 60S acidic ribosomal protein P2, putative |
Trichomonas vaginalis | TVAG_384610 | 60S acidic ribosomal protein P2, putative |
Trichomonas vaginalis | TVAG_402500 | 60S acidic ribosomal protein P2, putative |
Trichomonas vaginalis | TVAG_291690 | 60S acidic ribosomal protein P2, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.5120 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.5120 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.5120 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.6.5120 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb09.160.4200 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.4200 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.4200 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb09.160.4200 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y62E10A.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y62E10A.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C37A2.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C37A2.7 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C37A2.7 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_0407700 | Plasmodium berghei | Essential | plasmo |
TGME49_309810 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.