Detailed view for Bm1_11535

Basic information

TDR Targets ID: 244661
Brugia malayi, ubiquitin-conjugating enzyme E2-17 kDa
Source Database / ID:  GenBank

pI: 7.1864 | Length (AA): 147 | MW (Da): 16695 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00179   Ubiquitin-conjugating enzyme

Gene Ontology

Mouse over links to read term descriptions.
GO:0019787   small conjugating protein ligase activity  
GO:0051246   regulation of protein metabolic process  
GO:0043687   post-translational protein modification  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 147 4x57 (A) 1 147 80.00 0 1 2.1236 -2.31
1 147 4ddg (A) 1 147 91.00 0 1 2.2196 -2.17

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126877)

Species Accession Gene Product
Arabidopsis thaliana AT5G56150   ubiquitin-conjugating enzyme E2 30
Arabidopsis thaliana AT1G64230   ubiquitin-conjugating enzyme E2 28
Arabidopsis thaliana AT4G27960   ubiquitin conjugating enzyme 9
Arabidopsis thaliana AT5G41700   ubiquitin-conjugating enzyme E2 8
Arabidopsis thaliana AT2G16740   ubiquitin-conjugating enzyme E2 29
Arabidopsis thaliana AT3G08690   ubiquitin-conjugating enzyme 11
Babesia bovis BBOV_IV002040   ubiquitin-conjugating enzyme E2
Brugia malayi Bm1_39685   ubiquitin-conjugating enzyme ubc-2
Brugia malayi Bm1_11535   ubiquitin-conjugating enzyme E2-17 kDa
Candida albicans CaO19.7571   likely ubiquitin-conjugating enzyme similar to S. cerevisiae UBC4 (YBR082C) and UBC5 (YDR059C) proteasome complex ubiquitin conj
Caenorhabditis elegans CELE_M7.1   Protein LET-70
Cryptosporidium hominis Chro.40073   ubiquitin-conjugating enzyme
Cryptosporidium parvum cgd4_570   ubiquitin-conjugating enzyme
Dictyostelium discoideum DDB_G0290547   hypothetical protein
Drosophila melanogaster Dmel_CG7425   effete
Echinococcus granulosus EgrG_001125400   ubiquitin conjugating enzyme E2 17 kDa
Echinococcus granulosus EgrG_000093700   ubiquitin conjugating enzyme E2 D2
Entamoeba histolytica EHI_070750   ubiquitin-conjugating enzyme family protein
Entamoeba histolytica EHI_083560   ubiquitin-conjugating enzyme family protein
Echinococcus multilocularis EmuJ_000093700   ubiquitin conjugating enzyme E2 D2
Echinococcus multilocularis EmuJ_001125400   ubiquitin conjugating enzyme E2 17 kDa
Giardia lamblia GL50803_15252   Ubiquitin-conjugating enzyme E2-17 kDa 3
Homo sapiens ENSG00000078967   ubiquitin-conjugating enzyme E2D 4 (putative)
Homo sapiens ENSG00000072401   ubiquitin-conjugating enzyme E2D 1
Homo sapiens ENSG00000131508   ubiquitin-conjugating enzyme E2D 2
Homo sapiens ENSG00000109332   ubiquitin-conjugating enzyme E2D 3
Leishmania braziliensis LbrM.34.1220   ubiquitin-conjugating enzyme e2, putative
Leishmania donovani LdBPK_351310.1   ubiquitin-conjugating enzyme E2, putative
Leishmania infantum LinJ.35.1310   ubiquitin-conjugating enzyme e2, putative
Leishmania major LmjF.35.1300   ubiquitin-conjugating enzyme e2, putative
Leishmania mexicana LmxM.34.1300   ubiquitin-conjugating enzyme e2, putative
Loa Loa (eye worm) LOAG_02883   ubiquitin-conjugating enzyme ubc-2
Loa Loa (eye worm) LOAG_06620   ubiquitin-conjugating enzyme E
Mus musculus ENSMUSG00000019927   ubiquitin-conjugating enzyme E2D 1
Mus musculus ENSMUSG00000063447   ubiquitin-conjugating enzyme E2D 2B
Mus musculus ENSMUSG00000091896   ubiquitin-conjugating enzyme E2D 2A
Mus musculus ENSMUSG00000078578   ubiquitin-conjugating enzyme E2D 3
Neospora caninum NCLIV_010370   Ubiquitin carrier protein (EC 6.3.2.-), related
Oryza sativa 4327162   Os01g0658400
Oryza sativa 4327450   Os01g0819400
Oryza sativa 4328940   Os02g0261100
Oryza sativa 4346639   Os09g0293400
Oryza sativa 4328114   Os02g0120600
Oryza sativa 9266118   Os07g0174601
Oryza sativa 4337331   Os04g0667800
Plasmodium berghei PBANKA_0602800   ubiquitin-conjugating enzyme E2, putative
Plasmodium falciparum PF3D7_1203900   ubiquitin-conjugating enzyme E2
Plasmodium knowlesi PKNH_1303600   ubiquitin-conjugating enzyme E2, putative
Plasmodium vivax PVX_084235   ubiquitin-conjugating enzyme E2 4, putative
Plasmodium yoelii PY03025   putative ubiquitin-conjugating enzyme
Saccharomyces cerevisiae YDR059C   E2 ubiquitin-conjugating protein UBC5
Saccharomyces cerevisiae YBR082C   E2 ubiquitin-conjugating protein UBC4
Schistosoma japonicum Sjp_0102150   similar to Ubiquitin-conjugating enzyme E2-17 kDa, putative
Schistosoma mansoni Smp_068000   ubiquitin conjugating enzyme E2
Schistosoma mansoni Smp_067990.4   ubiquitin conjugating enzyme E2
Schistosoma mansoni Smp_067980.4   ubiquitin conjugating enzyme E2
Schmidtea mediterranea mk4.000425.01   Putative ubiquitin-conjugating enzyme morgue
Schmidtea mediterranea mk4.012434.00   Putative ubiquitin-conjugating enzyme morgue
Schmidtea mediterranea mk4.029333.00   Putative ubiquitin-conjugating enzyme morgue
Schmidtea mediterranea mk4.001273.03   Putative ubiquitin-conjugating enzyme morgue
Schmidtea mediterranea mk4.004609.02   Putative ubiquitin-conjugating enzyme morgue
Schmidtea mediterranea mk4.001415.03   Putative ubiquitin-conjugating enzyme morgue
Schmidtea mediterranea mk4.004245.01   Putative ubiquitin-conjugating enzyme morgue
Schmidtea mediterranea mk4.005313.04   Putative ubiquitin-conjugating enzyme morgue
Schmidtea mediterranea mk4.000055.09  
Schmidtea mediterranea mk4.000831.05   Putative ubiquitin-conjugating enzyme morgue
Schmidtea mediterranea mk4.001273.00   Putative ubiquitin-conjugating enzyme morgue
Schmidtea mediterranea mk4.000831.09   Putative ubiquitin-conjugating enzyme morgue
Schmidtea mediterranea mk4.004609.00   Putative ubiquitin-conjugating enzyme morgue
Schmidtea mediterranea mk4.000203.04   Putative ubiquitin-conjugating enzyme morgue
Trypanosoma brucei gambiense Tbg972.5.1360   ubiquitin-conjugating enzyme e2, putative,ubiquitin carrier protein, putative,ubiquitin-protein ligase, putative
Trypanosoma brucei Tb927.5.1000   ubiquitin-conjugating enzyme E2, putative
Trypanosoma congolense TcIL3000_5_740   ubiquitin-conjugating enzyme E2, putative
Trypanosoma cruzi TcCLB.511179.160   ubiquitin-conjugating enzyme E2, putative
Trypanosoma cruzi TcCLB.508303.4   ubiquitin-conjugating enzyme E2, putative
Toxoplasma gondii TGME49_319870   ubiquitin-conjugating enzyme subfamily protein
Theileria parva TP03_0448   ubiquitin-conjugating enzyme, putative
Trichomonas vaginalis TVAG_198290   ubiquitin-conjugating enzyme E2-25kD, putative
Trichomonas vaginalis TVAG_244240   ubiquitin-conjugating enzyme E2t, putative

Essentiality

Bm1_11535 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.5.1000 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.5.1000 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.5.1000 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.5.1000 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_M7.1 Caenorhabditis elegans adult lethal wormbase
CELE_M7.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_M7.1 Caenorhabditis elegans larval arrest wormbase
CELE_M7.1 Caenorhabditis elegans larval lethal wormbase
CELE_M7.1 Caenorhabditis elegans slow growth wormbase
CELE_M7.1 Caenorhabditis elegans sterile wormbase
PBANKA_0602800 Plasmodium berghei Essential plasmo
TGME49_319870 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Bm1_11535 (Brugia malayi), ubiquitin-conjugating enzyme E2-17 kDa
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