Detailed view for Bm1_08540

Basic information

TDR Targets ID: 244692
Brugia malayi, Rhomboid family protein
Source Database / ID:  GenBank

pI: 10.6164 | Length (AA): 351 | MW (Da): 40589 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01694   Rhomboid family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0004252   serine-type endopeptidase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
178 315 2nr9 (A) 60 186 28.00 0.019 0.12 0.516862 0.82

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127742)

Species Accession Gene Product
Arabidopsis thaliana AT1G18600   RHOMBOID-like protein 12
Brugia malayi Bm1_08540   Rhomboid family protein
Candida albicans CaO19.9210   similar to S. cerevisiae PCP1 (YGR101W) mitochondrial peptidase
Candida albicans CaO19.1643   potential Rhomboid family intramembrane protease
Caenorhabditis elegans CELE_Y54E10A.14   Protein ROM-5
Dictyostelium discoideum DDB_G0284937   rhomboid family protein
Dictyostelium discoideum DDB_G0292430   hypothetical protein
Drosophila melanogaster Dmel_CG8972   rhomboid-7
Echinococcus granulosus EgrG_000435100   presenilin associated rhomboid
Echinococcus multilocularis EmuJ_000435100   presenilin associated, rhomboid
Homo sapiens ENSG00000175193   presenilin associated, rhomboid-like
Loa Loa (eye worm) LOAG_01535   rhomboid family protein
Mus musculus ENSMUSG00000033918   presenilin associated, rhomboid-like
Oryza sativa 4327031   Os01g0763100
Plasmodium berghei PBANKA_1114700   rhomboid protease ROM9
Plasmodium falciparum PF3D7_0515100   rhomboid protease ROM9
Plasmodium knowlesi PKNH_0913300   rhomboid protease ROM9, putative
Plasmodium vivax PVX_080490   rhomboid protease ROM9, putative
Plasmodium yoelii PY03223   hypothetical protein
Saccharomyces cerevisiae YGR101W   Pcp1p
Schistosoma japonicum Sjp_0096100   ko:K09650 rhomboid-like protein, putative
Schistosoma mansoni Smp_032420   Rhomboid-7 peptidase (S54 family)
Treponema pallidum TP0982   glpG protein

Essentiality

Bm1_08540 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1114700 Plasmodium berghei Dispensable plasmo
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_08540 (Brugia malayi), Rhomboid family protein
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