Detailed view for Bm1_36760

Basic information

TDR Targets ID: 244789
Brugia malayi, Prefoldin subunit 4
Source Database / ID:  GenBank

pI: 4.3059 | Length (AA): 132 | MW (Da): 15222 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01920   Prefoldin subunit

Gene Ontology

Mouse over links to read term descriptions.
GO:0016272   prefoldin complex  
GO:0051082   unfolded protein binding  
GO:0006457   protein folding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
11 115 2zqm (A) 3 107 18.00 0.000022 0.62 1.10185 -0.99
27 111 2zdi (A) 18 103 26.00 0.53 0.98 1.12634 -1.43
32 98 2ld6 (A) 12 81 34.00 0.44 0.8 0.896976 -0.48

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128513)

Species Accession Gene Product
Arabidopsis thaliana AT1G08780   ABI3-interacting protein 3
Babesia bovis BBOV_III002880   KE2 family protein
Brugia malayi Bm1_36760   Prefoldin subunit 4
Candida albicans CaO19.1273   similar to S. cerevisiae GIM3 (YNL153C) prefoldin subunit 4, component of Gim protein complex involved in tubulin folding
Candida albicans CaO19.8859   similar to S. cerevisiae GIM3 (YNL153C) prefoldin subunit 4, component of Gim protein complex involved in tubulin folding
Caenorhabditis elegans CELE_B0035.4   Protein PFD-4
Cryptosporidium parvum cgd7_530   hypothetical protein
Dictyostelium discoideum DDB_G0281873   prefoldin beta-like domain containing protein
Drosophila melanogaster Dmel_CG10635   CG10635 gene product from transcript CG10635-RA
Echinococcus granulosus EgrG_000449900   prefoldin subunit 4
Echinococcus multilocularis EmuJ_000449900   prefoldin subunit 4
Giardia lamblia GL50803_1383   Hypothetical protein
Homo sapiens ENSG00000101132   prefoldin subunit 4
Leishmania braziliensis LbrM.25.0700   hypothetical protein, conserved
Leishmania donovani LdBPK_250850.1   prefoldin subunit, putative
Leishmania infantum LinJ.25.0850   hypothetical protein, conserved
Leishmania major LmjF.25.0820   hypothetical protein, conserved
Leishmania mexicana LmxM.25.0820   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_08739   prefoldin subunit 4
Mus musculus ENSMUSG00000052033   prefoldin 4
Neospora caninum NCLIV_041580   prefoldin subunit, putative
Oryza sativa 4333507   Os03g0628900
Plasmodium berghei PBANKA_0416900   prefoldin subunit 4, putative
Plasmodium falciparum PF3D7_0904500   prefoldin subunit 4, putative
Plasmodium knowlesi PKNH_0702200   prefoldin subunit 4, putative
Plasmodium vivax PVX_098670   prefoldin subunit, putative
Plasmodium yoelii PY06424   hypothetical protein
Saccharomyces cerevisiae YNL153C   Gim3p
Schistosoma japonicum Sjp_0070230   ko:K09550 prefoldin subunit 4, putative
Schistosoma mansoni Smp_151230   hypothetical protein
Trypanosoma brucei gambiense Tbg972.11.840   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.800   prefoldin subunit, putative
Trypanosoma congolense TcIL3000.11.760   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506925.190   prefoldin subunit, putative
Toxoplasma gondii TGME49_289210   prefoldin subunit protein
Theileria parva TP04_0109   hypothetical protein
Trichomonas vaginalis TVAG_159790   prefoldin subunit, putative

Essentiality

Bm1_36760 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.03.0335 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.03.0335 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.03.0335 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.03.0335 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0416900 Plasmodium berghei Slow plasmo
TGME49_289210 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Bm1_36760 (Brugia malayi), Prefoldin subunit 4
Title for this comment
Comment