Detailed view for Bm1_21525

Basic information

TDR Targets ID: 244809
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 7.8912 | Length (AA): 176 | MW (Da): 19606 | Paralog Number: 59

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
37 105 2i13 (A) 71 141 28.00 0.0029 0.16 0.531945 0.97

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129992)

Species Accession Gene Product
Brugia malayi Bm1_04020   hypothetical protein
Brugia malayi Bm1_09890   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_27210   hypothetical protein
Brugia malayi Bm1_10285   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_26410   hypothetical protein
Brugia malayi Bm1_26240   hypothetical protein
Brugia malayi Bm1_05860   hypothetical protein
Brugia malayi Bm1_53865   hypothetical protein
Brugia malayi Bm1_27200   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_09140   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_09995   hypothetical protein
Brugia malayi Bm1_03330   hypothetical protein
Brugia malayi Bm1_13105   hypothetical protein
Brugia malayi Bm1_20865   hypothetical protein
Brugia malayi Bm1_53415   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_01400   hypothetical protein
Brugia malayi Bm1_28205   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_04085   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_21525   hypothetical protein
Brugia malayi Bm1_10925   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_13400   hypothetical protein
Brugia malayi Bm1_12915   hypothetical protein
Brugia malayi Bm1_01815   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_23685   hypothetical protein
Brugia malayi Bm1_36250   hypothetical protein
Brugia malayi Bm1_19010   hypothetical protein
Brugia malayi Bm1_55180   hypothetical protein
Brugia malayi Bm1_18125   hypothetical protein
Brugia malayi Bm1_00465   hypothetical protein
Brugia malayi Bm1_23230   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_26770   hypothetical protein
Brugia malayi Bm1_11615   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_55170   hypothetical protein
Brugia malayi Bm1_19820   hypothetical protein
Brugia malayi Bm1_24360   hypothetical protein
Brugia malayi Bm1_56005   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_12575   IgG and IgE immunoreactive antigen recognized by sera from patients with strongyloidiasis
Brugia malayi Bm1_54100   hypothetical protein
Brugia malayi Bm1_18420   hypothetical protein
Brugia malayi Bm1_23590   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_04015   hypothetical protein
Brugia malayi Bm1_20860   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_21340   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_15125   Translation initiation factor IF-2
Brugia malayi Bm1_55905   hypothetical protein
Brugia malayi Bm1_19005   hypothetical protein
Brugia malayi Bm1_12155   hypothetical protein
Brugia malayi Bm1_02250   hypothetical protein
Brugia malayi Bm1_26775   hypothetical protein
Brugia malayi Bm1_03570   hypothetical protein
Brugia malayi Bm1_20480   hypothetical protein
Brugia malayi Bm1_18735   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_10460   hypothetical protein
Brugia malayi Bm1_02125   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_05040   hypothetical protein
Brugia malayi Bm1_09925   hypothetical protein
Brugia malayi Bm1_53120   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_02335   hypothetical protein
Brugia malayi Bm1_19000   hypothetical protein
Brugia malayi Bm1_10765   hypothetical protein
Loa Loa (eye worm) LOAG_14402   hypothetical protein
Loa Loa (eye worm) LOAG_14362   zinc finger protein
Loa Loa (eye worm) LOAG_15071   zinc finger protein
Loa Loa (eye worm) LOAG_15978   hypothetical protein
Loa Loa (eye worm) LOAG_15290   hypothetical protein
Loa Loa (eye worm) LOAG_14928   hypothetical protein
Loa Loa (eye worm) LOAG_10601   hypothetical protein
Loa Loa (eye worm) LOAG_15637   zinc finger protein
Loa Loa (eye worm) LOAG_13841   zinc finger protein
Loa Loa (eye worm) LOAG_08184   hypothetical protein
Loa Loa (eye worm) LOAG_14057   zinc finger protein
Loa Loa (eye worm) LOAG_11499   hypothetical protein
Loa Loa (eye worm) LOAG_14722   hypothetical protein
Loa Loa (eye worm) LOAG_14436   hypothetical protein
Loa Loa (eye worm) LOAG_15672   hypothetical protein
Loa Loa (eye worm) LOAG_15155   zinc finger protein
Loa Loa (eye worm) LOAG_15828   hypothetical protein
Loa Loa (eye worm) LOAG_15401   translation initiation factor IF-2
Loa Loa (eye worm) LOAG_13397   hypothetical protein
Loa Loa (eye worm) LOAG_08588   hypothetical protein
Loa Loa (eye worm) LOAG_15312   hypothetical protein
Loa Loa (eye worm) LOAG_13989   hypothetical protein
Loa Loa (eye worm) LOAG_13208   hypothetical protein
Loa Loa (eye worm) LOAG_15069   hypothetical protein
Loa Loa (eye worm) LOAG_08587   hypothetical protein
Loa Loa (eye worm) LOAG_14942   zinc finger protein
Loa Loa (eye worm) LOAG_15417   hypothetical protein
Loa Loa (eye worm) LOAG_15007   zinc finger protein
Loa Loa (eye worm) LOAG_12609   zinc finger protein
Loa Loa (eye worm) LOAG_13206   hypothetical protein
Loa Loa (eye worm) LOAG_15423   hypothetical protein
Loa Loa (eye worm) LOAG_13671   zinc finger protein
Loa Loa (eye worm) LOAG_08276   zinc finger protein
Loa Loa (eye worm) LOAG_13427   hypothetical protein
Loa Loa (eye worm) LOAG_13376   hypothetical protein
Loa Loa (eye worm) LOAG_09722   hypothetical protein
Onchocerca volvulus OVOC7614  
Onchocerca volvulus OVOC12014  
Onchocerca volvulus OVOC12866  
Onchocerca volvulus OVOC11975  
Onchocerca volvulus OVOC9670  
Onchocerca volvulus OVOC11509  
Onchocerca volvulus OVOC11994  
Onchocerca volvulus OVOC7593  
Onchocerca volvulus OVOC1347  
Onchocerca volvulus OVOC3455  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_21525 (Brugia malayi), hypothetical protein
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