Detailed view for Bm1_44490

Basic information

TDR Targets ID: 244837
Brugia malayi, vitamin K epoxide reductase complex, subunit 1, putative
Source Database / ID:  GenBank

pI: 7.2069 | Length (AA): 114 | MW (Da): 12544 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07884   Vitamin K epoxide reductase family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131145)

Species Accession Gene Product
Brugia malayi Bm1_44490   vitamin K epoxide reductase complex, subunit 1, putative
Drosophila melanogaster Dmel_CG33544   Vitamin-K epoxide reductase
Homo sapiens ENSG00000167397   vitamin K epoxide reductase complex, subunit 1
Leishmania braziliensis LbrM.27.2370   hypothetical protein, conserved
Leishmania donovani LdBPK_272110.1   Vitamin K epoxide reductase family, putative
Leishmania infantum LinJ.27.2110   hypothetical protein, conserved
Leishmania major LmjF.27.2190   hypothetical protein, conserved
Leishmania mexicana LmxM.27.2190   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_06369   vitamin K epoxide reductase complex
Mus musculus ENSMUSG00000096145   vitamin K epoxide reductase complex, subunit 1
Neospora caninum NCLIV_065890   vitamin K epoxide reductase complex subunit 1, putative
Onchocerca volvulus OVOC8279  
Schmidtea mediterranea mk4.005513.00   Vitamin-K epoxide reductase
Schmidtea mediterranea mk4.036620.00   Vitamin-K epoxide reductase
Trypanosoma brucei gambiense Tbg.972.2.2880   hypothetical protein, conserved
Trypanosoma brucei Tb927.2.4840   Vitamin K epoxide reductase family, putative
Trypanosoma congolense TcIL3000_2_1040   Vitamin K epoxide reductase family, putative
Trypanosoma cruzi TcCLB.511621.170   Vitamin K epoxide reductase family, putative
Trypanosoma cruzi TcCLB.504741.190   Vitamin K epoxide reductase family, putative
Toxoplasma gondii TGME49_249760   vitamin k epoxide reductase family protein

Essentiality

Bm1_44490 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.2.4840 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.4840 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.4840 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.2.4840 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_249760 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Bos taurus Vitamin k epoxide reductase complex subunit 1 isoform 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0133 0.3317 1
0.0186 0.4952 0.4952
0.0133 0.2655 0.3573

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_44490 (Brugia malayi), vitamin K epoxide reductase complex, subunit 1, putative
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