Detailed view for LmjF.36.0980

Basic information

TDR Targets ID: 24707
Leishmania major, 40S ribosomal protein S10, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 10.9909 | Length (AA): 168 | MW (Da): 18650 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03501   Plectin/S10 domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_127137)

Species Accession Gene Product
Arabidopsis thaliana AT5G52650   40S ribosomal protein S10-3
Arabidopsis thaliana AT4G25740   40S ribosomal protein S10-1
Arabidopsis thaliana AT5G41520   40S ribosomal protein S10-2
Babesia bovis BBOV_III009270   plectin/S10 domain containing protein
Brugia malayi Bm1_17195   40S ribosomal protein S10
Caenorhabditis elegans CELE_D1007.6   Protein RPS-10
Cryptosporidium hominis Chro.50097   ribosomal protein S10
Cryptosporidium parvum cgd5_2780   40S ribosomal protein S10
Dictyostelium discoideum DDB_G0286117   40S ribosomal protein S10
Drosophila melanogaster Dmel_CG12275   Ribosomal protein S10a
Drosophila melanogaster Dmel_CG14206   Ribosomal protein S10b
Echinococcus granulosus EgrG_000782400   40S ribosomal protein S10
Entamoeba histolytica EHI_197030   40S ribosomal protein S10, putative
Echinococcus multilocularis EmuJ_000782400   40S ribosomal protein S10
Giardia lamblia GL50803_10919   Ribosomal protein S10B
Homo sapiens ENSG00000124614   ribosomal protein S10
Homo sapiens 100529239   RPS10-NUDT3 readthrough
Leishmania braziliensis LbrM.35.1110   40S ribosomal protein S10, putative
Leishmania braziliensis LbrM.35.1100   40S ribosomal protein S10, putative
Leishmania donovani LdBPK_361050.1   40S ribosomal protein S10, putative
Leishmania infantum LinJ.36.1040   40S ribosomal protein S10, putative
Leishmania infantum LinJ.36.1050   40S ribosomal protein S10, putative
Leishmania major LmjF.36.0990   40S ribosomal protein S10, putative
Leishmania major LmjF.36.0980   40S ribosomal protein S10, putative
Leishmania mexicana LmxM.36.0980   40S ribosomal protein S10, putative
Leishmania mexicana LmxM.36.0990   40S ribosomal protein S10, putative
Loa Loa (eye worm) LOAG_07069   40S ribosomal protein S10
Mus musculus ENSMUSG00000052146   ribosomal protein S10
Neospora caninum NCLIV_007110   hypothetical protein
Oryza sativa 4329619   Os02g0549600
Oryza sativa 4324553   Os01g0962600
Oryza sativa 4335865   Os04g0430100
Plasmodium berghei PBANKA_0617200   40S ribosomal protein S10, putative
Plasmodium falciparum PF3D7_0719700   40S ribosomal protein S10, putative
Plasmodium knowlesi PKNH_0315100   40S ribosomal protein S10, putative
Plasmodium vivax PVX_096335   40S ribosomal protein S10, putative
Plasmodium yoelii PY02462   ribosomal protein S10
Saccharomyces cerevisiae YMR230W   ribosomal 40S subunit protein S10B
Saccharomyces cerevisiae YOR293W   ribosomal 40S subunit protein S10A
Schistosoma japonicum Sjp_0103750   ko:K02947 small subunit ribosomal protein S10e, putative
Schistosoma mansoni Smp_066890   40S ribosomal protein S10
Trypanosoma brucei gambiense Tbg972.10.6550   40S ribosomal protein S10, putative
Trypanosoma brucei gambiense Tbg972.10.6570   40S ribosomal protein S10, putative
Trypanosoma brucei Tb927.10.5370   40S ribosomal protein S10, putative
Trypanosoma brucei Tb927.10.5360   40S ribosomal protein S10, putative
Trypanosoma congolense TcIL3000_10_4510   40S ribosomal protein S10, putative
Trypanosoma congolense TcIL3000_10_4520   40S ribosomal protein S10, putative
Trypanosoma cruzi TcCLB.506679.150   40S ribosomal protein S10, putative
Trypanosoma cruzi TcCLB.506679.140   40S ribosomal protein S10, putative
Toxoplasma gondii TGME49_275810   ribosomal protein RPS10
Theileria parva TP04_0836   40S ribosomal protein S10, putative
Trichomonas vaginalis TVAG_120180   40S ribosomal protein S10, putative
Trichomonas vaginalis TVAG_329340   40S ribosomal protein S10, putative
Trichomonas vaginalis TVAG_454860   40S ribosomal protein S10, putative
Trichomonas vaginalis TVAG_371330   40S ribosomal protein S10, putative

Essentiality

LmjF.36.0980 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.5370 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.5370 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.5370 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.5370 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_D1007.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_D1007.6 Caenorhabditis elegans larval arrest wormbase
CELE_D1007.6 Caenorhabditis elegans sterile wormbase
YOR293W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0617200 Plasmodium berghei Essential plasmo
TGME49_275810 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LmjF.36.0980 (Leishmania major), 40S ribosomal protein S10, putative
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