Detailed view for LmjF.06.0570

Basic information

TDR Targets ID: 24733
Leishmania major, 60S ribosomal protein L23a, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 11.2311 | Length (AA): 145 | MW (Da): 16336 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00276   Ribosomal protein L23

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0000166   nucleotide binding  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
62 142 1vq8 (S) 1 81 42.00 0.000000000036 1 1.15232 -0.85
62 131 4wfa (Q) 3 84 31.00 0 0.99 0.709959 -0.37

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_126659)

Species Accession Gene Product
Arabidopsis thaliana AT2G39460   60S ribosomal protein L23a-1
Arabidopsis thaliana ArthCp084   50S ribosomal protein L23
Arabidopsis thaliana ArthCp065   50S ribosomal protein L23
Arabidopsis thaliana AT4G39880   ribosomal protein L23/L15e family protein
Arabidopsis thaliana AT3G55280   60S ribosomal protein L23a-2
Babesia bovis BBOV_III001580   60S ribosomal protein L23, putative
Brugia malayi Bm1_04800   60S ribosomal protein L23a
Caenorhabditis elegans CELE_F55D10.2   Protein RPL-25.1
Caenorhabditis elegans CELE_F52B5.6   Protein RPL-25.2
Cryptosporidium hominis Chro.80080   ribosomal protein L23a
Cryptosporidium parvum cgd8_650   60S ribosomal protein L23A
Chlamydia trachomatis CT_526   50S ribosomal protein L23
Dictyostelium discoideum DDB_G0293502   S60 ribosomal protein L23a
Drosophila melanogaster Dmel_CG7977   Ribosomal protein L23A
Escherichia coli b3318   50S ribosomal subunit protein L23
Echinococcus granulosus EgrG_000556100   60S ribosomal protein L23a
Entamoeba histolytica EHI_182850   ribosomal protein L23A, putative
Echinococcus multilocularis EmuJ_000556100   60S ribosomal protein L23a
Giardia lamblia GL50803_7870   Ribosomal protein L23A
Homo sapiens 6147   ribosomal protein L23a
Leishmania braziliensis LbrM.06.0590   60S ribosomal protein L23a, putative
Leishmania braziliensis LbrM.06.0580   60S ribosomal protein L23a, putative
Leishmania donovani LdBPK_060590.1   60S ribosomal protein L23a, putative
Leishmania infantum LinJ.06.0600   60S ribosomal protein L23a, putative
Leishmania major LmjF.06.0570   60S ribosomal protein L23a, putative
Leishmania major LmjF.06.0580   60S ribosomal protein L23a, putative
Leishmania mexicana LmxM.06.0570   60S ribosomal protein L23a, putative
Leishmania mexicana LmxM.06.0580   60S ribosomal protein L23a, putative
Loa Loa (eye worm) LOAG_02835   60S ribosomal protein L23a
Mycobacterium leprae ML1861c   PROBABLE 50S RIBOSOMAL PROTEIN L23 RPLW
Mus musculus ENSMUSG00000058546   ribosomal protein L23A
Mus musculus 666790   predicted gene 8290
Mus musculus 102638521   60S ribosomal protein L23a-like
Mycobacterium tuberculosis Rv0703   50S ribosomal protein L23 RplW
Mycobacterium ulcerans MUL_0792   50S ribosomal protein L23
Neospora caninum NCLIV_015410   hypothetical protein
Oryza sativa 4326469   Os01g0348700
Oryza sativa 4336307   Os04g0501000
Oryza sativa 3131427   50S ribosomal protein L23
Oryza sativa 3131428   50S ribosomal protein L23
Oryza sativa 4343020   Os07g0415200
Onchocerca volvulus OVOC2538   60S ribosomal protein L23a homolog
Plasmodium berghei PBANKA_1338600   60S ribosomal protein L23, putative
Plasmodium falciparum PF3D7_1323400   60S ribosomal protein L23
Plasmodium knowlesi PKNH_1205400   60S ribosomal protein L23, putative
Plasmodium vivax PVX_116700   60S ribosomal protein L23, putative
Plasmodium yoelii PY04600   60S ribosomal protein L23a
Saccharomyces cerevisiae YOL127W   ribosomal 60S subunit protein L25
Schistosoma japonicum Sjp_0208030   ko:K02893 large subunit ribosomal protein L23Ae, putative
Schistosoma mansoni Smp_003410   60S ribosomal protein L23a
Schmidtea mediterranea mk4.003461.00   60S ribosomal protein L23a
Schmidtea mediterranea mk4.004166.03   60S ribosomal protein L23a
Trypanosoma brucei gambiense Tbg972.7.5950   60S ribosomal protein L23a, putative
Trypanosoma brucei gambiense Tbg972.7.5960   60S ribosomal protein L23a, putative
Trypanosoma brucei Tb927.7.5170   60S ribosomal protein L25
Trypanosoma brucei Tb927.7.5180   60S ribosomal protein L23a, putative
Trypanosoma congolense TcIL3000_0_13170   60S ribosomal protein L23a
Trypanosoma cruzi TcCLB.509151.140   60S ribosomal protein L23a, putative
Trypanosoma cruzi TcCLB.508175.146   60S ribosomal protein L23a, putative
Toxoplasma gondii TGME49_238010   ribosomal protein RPL23A
Treponema pallidum TP0191   50S ribosomal protein L23
Theileria parva TP03_0683   60S ribosomal protein L23a, putative
Trichomonas vaginalis TVAG_093600   60S ribosomal protein L23a, putative
Trichomonas vaginalis TVAG_160160   60S ribosomal protein L23a, putative
Trichomonas vaginalis TVAG_224750   60S ribosomal protein L23a, putative
Trichomonas vaginalis TVAG_433200   60S ribosomal protein L23a, putative
Trichomonas vaginalis TVAG_178000   60S ribosomal protein L23a, putative
Wolbachia endosymbiont of Brugia malayi Wbm0339   50S ribosomal protein L23

Essentiality

LmjF.06.0570 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu715 Mycobacterium tuberculosis essential nmpdr
Tb927.7.5170 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.7.5170 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.5170 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.7.5170 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b3318 Escherichia coli essential goodall
CELE_F55D10.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_F55D10.2 Caenorhabditis elegans larval arrest wormbase
CELE_F55D10.2 Caenorhabditis elegans slow growth wormbase
CELE_F55D10.2 Caenorhabditis elegans sterile wormbase
CELE_F52B5.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_F52B5.6 Caenorhabditis elegans slow growth wormbase
CELE_F52B5.6 Caenorhabditis elegans sterile wormbase
CELE_F52B5.6 Caenorhabditis elegans terminal arrest variable wormbase
YOL127W Saccharomyces cerevisiae inviable yeastgenome
TGME49_238010 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier LmjF.06.0570 (Leishmania major), 60S ribosomal protein L23a, putative
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