pI: 4.8497 |
Length (AA): 96 |
MW (Da): 11005 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 95 | 1xpp (A) | 8 | 100 | 18.00 | 0 | 0.28 | 1.21 | -0.96 |
5 | 92 | 1twf (K) | 20 | 108 | 36.00 | 0 | 0.97 | 1.44 | -0.84 |
20 | 94 | 1twf (K) | 35 | 102 | 51.00 | 0.0000000021 | 1 | 1.31 | -0.57 |
2 | 95 | 4c2m (K) | 45 | 141 | 43.00 | 0 | 1 | 1.57657 | -1.08 |
18 | 51 | 4qjv (B) | 15 | 48 | 53.00 | 0.00024 | 0.62 | 0.855967 | 0.82 |
20 | 94 | 1twf (K) | 35 | 102 | 51.00 | 0.0000000087 | 1 | 1.30305 | -0.5 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | merozoite, sporozoite, early ring, early trophozoite, late ring, late schizont, late trophozoite, Ring, Sporozoite. | PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, Oocyst, Female Gametocyte. | Otto TD Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, Male Gametocyte. | Otto TD Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 48 hs. | Otto TD |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Ortholog group members (OG5_128425)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G29540 | DNA-directed RNA polymerase RPAC14 |
Babesia bovis | BBOV_II001150 | RNA polymerase small subunit protein, putative |
Brugia malayi | Bm1_55240 | Probable DNA-directed RNA polymerases I/III 16 kDa polypeptide |
Candida albicans | CaO19.7805 | similar to S. cerevisiae RPC19 (YNL113W) subunit common to RNA polymerases I and III |
Candida albicans | CaO19.172 | similar to S. cerevisiae RPC19 (YNL113W) subunit common to RNA polymerases I and III |
Caenorhabditis elegans | CELE_F58A4.9 | Protein RPAC-19 |
Dictyostelium discoideum | DDB_G0291362 | hypothetical protein |
Drosophila melanogaster | Dmel_CG10685 | lethal (2) 37Cg |
Giardia lamblia | GL50803_10840 | DNA-directed RNA polymerases I and III 16 kDa polypeptide |
Leishmania braziliensis | LbrM.28.2250 | DNA-directed RNA polymerase-like protein |
Leishmania donovani | LdBPK_282200.1 | DNA-directed RNA polymerase-like protein |
Leishmania infantum | LinJ.28.2200 | DNA-directed RNA polymerase-like protein |
Leishmania major | LmjF.28.2060 | DNA-directed RNA polymerase-like protein |
Leishmania mexicana | LmxM.28.2060 | DNA-directed RNA polymerase-like protein |
Loa Loa (eye worm) | LOAG_02401 | hypothetical protein |
Mus musculus | ENSMUSG00000029642 | polymerase (RNA) I polypeptide D |
Neospora caninum | NCLIV_025940 | DNA-directed RNA polymerase I 16 kDa polypeptide, related |
Oryza sativa | 4351715 | Os12g0194700 |
Plasmodium berghei | PBANKA_1027500 | DNA-directed RNA polymerases I and III subunit RPAC2, putative |
Plasmodium falciparum | PF3D7_1415200 | DNA-directed RNA polymerases I and III subunit RPAC2, putative |
Plasmodium knowlesi | PKNH_1342900 | DNA-directed RNA polymerases I and III subunit RPAC2, putative |
Plasmodium vivax | PVX_085690 | RNA polymerase small subunit, putative |
Plasmodium yoelii | PY04455 | RNA polymerases L / 13 to 16 kDa subunit |
Saccharomyces cerevisiae | YNL113W | DNA-directed RNA polymerase core subunit RPC19 |
Trypanosoma brucei gambiense | Tbg972.11.9940 | DNA-dependent RNA polymerases, putative |
Trypanosoma brucei | Tb927.11.8890 | DNA-dependent RNA polymerases, putative |
Trypanosoma cruzi | TcCLB.511801.44 | DNA-dependent RNA polymerases, putative |
Trypanosoma cruzi | TcCLB.508601.30 | DNA-directed RNA polymerase I/III subunit, putative |
Toxoplasma gondii | TGME49_261540 | DNA-directed RNA polymerase I RPAC2 |
Theileria parva | TP04_0471 | RNA polymerase small subunit, putative |
Trichomonas vaginalis | TVAG_190340 | DNA-directed RNA polymerases I and III, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.0625 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.0625 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.0625 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.0625 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F58A4.9 | Caenorhabditis elegans | slow growth | wormbase |
YNL113W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_261540 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
16 literature references were collected for this gene.