Detailed view for LmjF.01.0530

Basic information

TDR Targets ID: 24844
Leishmania major, long-chain-fatty-acid-CoA ligase, putative

Source Database / ID:  TriTrypDB  GeneDB

pI: 7.1223 | Length (AA): 1607 | MW (Da): 168974 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00501   AMP-binding enzyme

Gene Ontology

Mouse over links to read term descriptions.
GO:0003824   catalytic activity  
GO:0008152   metabolic process  

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
850 1524 1lci () 5 544 16.00 0 0.8 0.1 0.63
35 257 1mtp (A) 36 287 30.00 0.62 0.31 0.146068 0.72
542 806 3pbk (A) 16 262 13.00 0.00000000011 0.24 0.178304 -0.03
583 646 4lgc (A) 61 124 14.00 0.00075 0.18 0.150226 0.34
808 854 2jrt (A) 47 91 47.00 0.49 0.27 0.396547 0.78
1259 1420 4isb (A) 286 418 40.00 0.00012 0.49 0.201109 1.07
1298 1498 3vnr (A) 303 498 31.00 0.0066 1 0.116378 1.17
1348 1529 4iz6 (A) 347 537 25.00 0.0041 1 0.298555 0.83

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein


Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.


Ortholog group members (OG5_183107)

Species Accession Gene Product
Leishmania braziliensis LbrM.01.0560   long-chain-fatty-acid-CoA ligase, putative
Leishmania donovani LdBPK_010550.1   long chain fatty acid CoA ligase, putative
Leishmania infantum LinJ.01.0550   long-chain-fatty-acid-CoA ligase, putative
Leishmania major LmjF.01.0530   long-chain-fatty-acid-CoA ligase, putative
Leishmania mexicana LmxM.01.0530   long-chain-fatty-acid-CoA ligase, putative


No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model


Assay information

  • Assay for Acyl Coenzyme A Synthetase ( ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

No reagent availability information for this target.

Bibliographic References

2 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.01.0530 (Leishmania major), long-chain-fatty-acid-CoA ligase, putative
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