Detailed view for LmjF.36.5120

Basic information

TDR Targets ID: 24908
Leishmania major, 40S ribosomal protein SA, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.7097 | Length (AA): 246 | MW (Da): 27500 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00318   Ribosomal protein S2

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0015935   small ribosomal subunit  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
18 212 1fjg (B) 7 243 27.00 0 1 0.97 -1.04
20 192 1vi6 (A) 14 185 38.00 0 1 1.37 -1.93
5 212 4kzy (A) 2 209 59.00 0 1 1.61183 -0.85
19 246 4toi (A) 7 287 22.00 0 1 0.956429 0.41

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_127014)

Species Accession Gene Product
Arabidopsis thaliana AT1G72370   40S ribosomal protein Sa-1
Arabidopsis thaliana AT3G04770   40S ribosomal protein Sa-2
Babesia bovis BBOV_III008460   40S ribosomal protein S2, putative
Brugia malayi Bm1_41245   laminin receptor 1
Caenorhabditis elegans CELE_B0393.1   Protein RPS-0
Cryptosporidium hominis Chro.30246   ribosomal protein S2
Cryptosporidium parvum cgd3_2090   40S ribosomal protein SAe
Dictyostelium discoideum DDB_G0270316   40S ribosomal protein SA
Drosophila melanogaster Dmel_CG14792   stubarista
Echinococcus granulosus EgrG_000720100   40S ribosomal protein SA
Entamoeba histolytica EHI_081410   40S ribosomal protein SA, putative
Entamoeba histolytica EHI_130260   40S ribosomal protein SA, putative
Echinococcus multilocularis EmuJ_000720100   40S ribosomal protein SA
Echinococcus multilocularis EmuJ_000148400   40S ribosomal protein SA
Giardia lamblia GL50803_7766   Ribosomal protein SA
Homo sapiens ENSG00000168028   ribosomal protein SA
Leishmania braziliensis LbrM.35.5370   40S ribosomal protein SA, putative
Leishmania donovani LdBPK_365353.1   40S ribosomal protein SA, putative
Leishmania infantum LinJ.36.5240   40S ribosomal protein SA, putative
Leishmania infantum LinJ.36.5350   40S ribosomal protein SA, putative
Leishmania major LmjF.36.5120   40S ribosomal protein SA, putative
Leishmania major LmjF.36.5010   40S ribosomal protein SA, putative
Leishmania mexicana LmxM.36.5010   40S ribosomal protein SA, putative
Leishmania mexicana LmxM.36.5120   40S ribosomal protein SA, putative
Loa Loa (eye worm) LOAG_02687   laminin receptor 1
Mus musculus ENSMUSG00000032518   ribosomal protein SA
Mus musculus 102642689   40S ribosomal protein SA-like
Mus musculus 102641427   40S ribosomal protein SA-like
Neospora caninum NCLIV_048020   hypothetical protein
Oryza sativa 4343909   Os07g0616600
Oryza sativa 9272225   Os03g0182600
Plasmodium berghei PBANKA_0510900   40S ribosomal protein S2, putative
Plasmodium falciparum PF3D7_1026800   40S ribosomal protein S2
Plasmodium knowlesi PKNH_0611200   40S ribosomal protein S2, putative
Plasmodium vivax PVX_111380   40S ribosomal protein S2, putative
Plasmodium yoelii PY06059   ribosomal protein S2, putative
Saccharomyces cerevisiae YGR214W   ribosomal 40S subunit protein S0A
Saccharomyces cerevisiae YLR048W   ribosomal 40S subunit protein S0B
Schistosoma japonicum Sjp_0058830   ko:K02998 small subunit ribosomal protein SAe, putative
Schistosoma mansoni Smp_179180   ribosomal protein S2 eukaryotic and archaeal form
Schistosoma mansoni Smp_081960   ribosomal protein S2 eukaryotic and archaeal form
Schmidtea mediterranea mk4.003393.01   40S ribosomal protein SA
Schmidtea mediterranea mk4.003748.00   40S ribosomal protein SA
Schmidtea mediterranea mk4.027958.00   40S ribosomal protein SA
Schmidtea mediterranea mk4.006482.01  
Schmidtea mediterranea mk4.000056.11   40S ribosomal protein SA
Schmidtea mediterranea mk4.001917.00  
Schmidtea mediterranea mk4.013565.00   40S ribosomal protein SA
Schmidtea mediterranea mk4.002206.00  
Schmidtea mediterranea mk4.021564.00   40S ribosomal protein SA
Schmidtea mediterranea mk4.025751.00   40S ribosomal protein SA
Schmidtea mediterranea mk4.001653.02   40S ribosomal protein SA
Schmidtea mediterranea mk4.010031.00  
Schmidtea mediterranea mk4.004791.00   40S ribosomal protein SA
Schmidtea mediterranea mk4.000897.09   40S ribosomal protein SA
Schmidtea mediterranea mk4.002732.03   40S ribosomal protein SA
Schmidtea mediterranea mk4.012297.01   40S ribosomal protein SA
Schmidtea mediterranea mk4.001791.05   40S ribosomal protein SA
Schmidtea mediterranea mk4.024176.00   40S ribosomal protein SA
Schmidtea mediterranea mk4.001297.01   40S ribosomal protein SA
Schmidtea mediterranea mk4.005777.01   40S ribosomal protein SA
Schmidtea mediterranea mk4.009157.00   40S ribosomal protein SA
Schmidtea mediterranea mk4.008576.06   40S ribosomal protein SA
Schmidtea mediterranea mk4.001528.03   40S ribosomal protein SA
Schmidtea mediterranea mk4.030307.00   40S ribosomal protein SA
Schmidtea mediterranea mk4.004717.00   40S ribosomal protein SA
Schmidtea mediterranea mk4.032567.00   40S ribosomal protein SA
Schmidtea mediterranea mk4.000005.20   40S ribosomal protein SA
Schmidtea mediterranea mk4.002738.04   40S ribosomal protein SA
Schmidtea mediterranea mk4.026072.01   40S ribosomal protein SA
Schmidtea mediterranea mk4.005921.03   40S ribosomal protein SA
Schmidtea mediterranea mk4.023622.00   40S ribosomal protein SA
Schmidtea mediterranea mk4.000393.03   40S ribosomal protein SA
Schmidtea mediterranea mk4.000966.10   40S ribosomal protein SA
Schmidtea mediterranea mk4.013599.01  
Schmidtea mediterranea mk4.024938.00   40S ribosomal protein SA
Schmidtea mediterranea mk4.007918.00   40S ribosomal protein SA
Trypanosoma brucei gambiense Tbg972.11.12090   40S ribosomal protein SA, putative
Trypanosoma brucei gambiense Tbg972.11.12220   40S ribosomal protein SA, putative
Trypanosoma brucei Tb927.11.10790   40S ribosomal protein SA, putative
Trypanosoma brucei Tb927.11.10910   40S ribosomal protein SA, putative
Trypanosoma congolense TcIL3000.11.11460   40S ribosomal protein SA, putative
Trypanosoma congolense TcIL3000.11.11590   40S ribosomal protein SA, putative
Trypanosoma cruzi TcCLB.503719.20   40S ribosomal protein SA, putative
Trypanosoma cruzi TcCLB.509825.14   40S ribosomal protein SA, putative
Trypanosoma cruzi TcCLB.510425.19   40S ribosomal protein SA, putative
Trypanosoma cruzi TcCLB.503757.10   40S ribosomal protein SA, putative
Trypanosoma cruzi TcCLB.442383.9   40S ribosomal protein SA, putative
Toxoplasma gondii TGME49_266060   ribosomal protein RPSA
Theileria parva TP04_0748   40S ribosomal protein SA, putative
Trichomonas vaginalis TVAG_498960   ribosomal protein S2, eukaryotic and archaeal form, putative
Trichomonas vaginalis TVAG_240050   40S ribosomal protein sa, putative
Trichomonas vaginalis TVAG_480600   40S ribosomal protein sa, putative
Trichomonas vaginalis TVAG_306190   ribosomal protein S2, eukaryotic and archaeal form, putative
Trichomonas vaginalis TVAG_474410   40S ribosomal protein sa, putative

Essentiality

LmjF.36.5120 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_B0393.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_B0393.1 Caenorhabditis elegans larval arrest wormbase
CELE_B0393.1 Caenorhabditis elegans slow growth wormbase
CELE_B0393.1 Caenorhabditis elegans sterile wormbase
PBANKA_0510900 Plasmodium berghei Essential plasmo
TGME49_266060 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

  • Lmaj006027AAA;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Lmaj006027; Recombinant protein: full-length; Source: L major; 40S ribosomal protein SA, putative ;

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.36.5120 (Leishmania major), 40S ribosomal protein SA, putative
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