pI: 7.7456 |
Length (AA): 374 |
MW (Da): 42109 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
64 | 228 | 2a5d (A) | 13 | 172 | 11.00 | 0.000000044 | 0.02 | 0.49 | -0.4 |
65 | 370 | 1wxq (A) | 1 | 395 | 22.00 | 0 | 1 | 0.8 | 0.26 |
2 | 370 | 4a9a (A) | 3 | 369 | 46.00 | 0 | 1 | 1.48523 | -0.03 |
286 | 368 | 2eki (A) | 2 | 85 | 49.00 | 0 | 1 | 0.792725 | -0.18 |
316 | 372 | 2kmm (A) | 432 | 481 | 18.00 | 0.000095 | 0.47 | 0.239006 | -0.24 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | amastigotes, metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_128226)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G17470 | developmentally regulated G-protein 1 |
Arabidopsis thaliana | AT1G72660 | developmentally regulated G-protein 2 |
Babesia bovis | BBOV_I003460 | GTP binding protein, putative |
Brugia malayi | Bm1_53710 | Hypothetical GTP-binding protein C02F5.3 in chromosome III |
Candida albicans | CaO19.3977 | probable GTP-binding protein |
Candida albicans | CaO19.11460 | probable GTP-binding protein |
Caenorhabditis elegans | CELE_C02F5.3 | Protein C02F5.3 |
Cryptosporidium hominis | Chro.30022 | developmentally regulated GTP-binding protein 2 |
Cryptosporidium parvum | cgd3_130 | DRG like OBG family GTpase fused to an RNA binding domain TGS domain, Fun11p |
Dictyostelium discoideum | DDB_G0279451 | hypothetical protein |
Drosophila melanogaster | Dmel_CG6195 | CG6195 gene product from transcript CG6195-RA |
Echinococcus granulosus | EgrG_000585000 | Developmentally regulated GTP binding protein 2 |
Echinococcus multilocularis | EmuJ_000585000 | Developmentally regulated GTP binding protein 2 |
Giardia lamblia | GL50803_5871 | Developmentally regulated GTP-binding protein 1 |
Homo sapiens | ENSG00000108591 | developmentally regulated GTP binding protein 2 |
Leishmania braziliensis | LbrM.34.5250 | GTP-binding protein, putative |
Leishmania donovani | LdBPK_355280.1 | GTP-binding protein, putative |
Leishmania infantum | LinJ.35.5280 | GTP-binding protein, putative |
Leishmania major | LmjF.35.5310 | GTP-binding protein, putative |
Leishmania mexicana | LmxM.34.5310 | GTP-binding protein, putative |
Loa Loa (eye worm) | LOAG_06419 | hypothetical protein |
Mus musculus | ENSMUSG00000020537 | developmentally regulated GTP binding protein 2 |
Neospora caninum | NCLIV_033060 | hypothetical protein |
Oryza sativa | 4338525 | Os05g0357600 |
Onchocerca volvulus | OVOC9372 |
|
Plasmodium berghei | PBANKA_1135200 | GTP-binding protein, putative |
Plasmodium falciparum | PF3D7_1358900 | GTP-binding protein, putative |
Plasmodium knowlesi | PKNH_1112400 | GTP-binding protein, putative |
Plasmodium vivax | PVX_114920 | GTP-binding protein, putative |
Plasmodium yoelii | PY03928 | developmentally regulated GTP-binding protein 2 |
Saccharomyces cerevisiae | YGR173W | Rbg2p |
Schistosoma japonicum | Sjp_0032590 | ko:K06944 DRG2; developmentally regulated GTP binding protein 2, putative |
Schistosoma mansoni | Smp_080550 | developmentally regulated GTP-binding protein 2 (drg 2) |
Schmidtea mediterranea | mk4.003450.03 | Putative developmentally regulated GTP-binding protein 2 |
Schmidtea mediterranea | mk4.005106.05 | Putative developmentally regulated GTP-binding protein 2 |
Trypanosoma brucei gambiense | Tbg972.9.5000 | developmentally regulated GTP-binding protein, putative |
Trypanosoma brucei | Tb927.9.9020 | ribosome-interacting GTPase 2, putative |
Trypanosoma cruzi | TcCLB.506883.30 | ribosome-interacting GTPase 2, putative |
Toxoplasma gondii | TGME49_233260 | GTP-binding protein, putative |
Trichomonas vaginalis | TVAG_123550 | developmentally regulated GTP-binding protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.211.0720 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb09.211.0720 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb09.211.0720 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb09.211.0720 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_233260 | Toxoplasma gondii | Probably non-essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.