pI: 9.3211 |
Length (AA): 183 |
MW (Da): 21071 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 127 | 3ccf (A) | 59 | 191 | 29.00 | 0.36 | 0.19 | 0.58476 | 1.59 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | amastigotes, metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_127650)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G23310 | protein RER1C1 |
Arabidopsis thaliana | AT2G21600 | protein RER1B |
Arabidopsis thaliana | AT4G39220 | protein RER1A |
Babesia bovis | BBOV_III001740 | Rer1 family protein |
Brugia malayi | Bm1_25765 | Hypothetical 22.6 kDa protein F46C5.8 in chromosome II, putative |
Candida albicans | CaO19_7202 | hypothetical protein |
Candida albicans | CaO19.7202 | Golgi protein |
Caenorhabditis elegans | CELE_F46C5.8 | Protein RER-1 |
Cryptosporidium parvum | cgd2_2250 | putative integral membrane protein |
Dictyostelium discoideum | DDB_G0292588 | hypothetical protein |
Drosophila melanogaster | Dmel_CG11857 | CG11857 gene product from transcript CG11857-RA |
Echinococcus granulosus | EgrG_000782800 | protein rer1 |
Echinococcus granulosus | EgrG_000100000 | RER1 retention in endoplasmic reticulum 1 |
Entamoeba histolytica | EHI_062460 | RER1 protein, putative |
Echinococcus multilocularis | EmuJ_000782800 | protein rer1 |
Echinococcus multilocularis | EmuJ_000100000 | RER1 retention in endoplasmic reticulum 1 |
Giardia lamblia | GL50803_15413 | RER1-like protein-retention of ER proteins |
Homo sapiens | ENSG00000157916 | retention in endoplasmic reticulum sorting receptor 1 |
Leishmania braziliensis | LbrM.22.0520 | rer1 family-like protein |
Leishmania donovani | LdBPK_220450.1 | rer1 family-like protein |
Leishmania infantum | LinJ.22.0450 | rer1 family-like protein |
Leishmania major | LmjF.22.0580 | rer1 family-like protein |
Leishmania mexicana | LmxM.22.0580 | rer1 family-like protein |
Loa Loa (eye worm) | LOAG_00599 | hypothetical protein |
Mus musculus | ENSMUSG00000029048 | RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae) |
Neospora caninum | NCLIV_043030 | hypothetical protein |
Oryza sativa | 4342020 | Os06g0708300 |
Oryza sativa | 4345237 | Os08g0309300 |
Oryza sativa | 4326147 | Os01g0106200 |
Plasmodium berghei | PBANKA_0418300 | protein RER1, putative |
Plasmodium falciparum | PF3D7_0903100 | protein RER1, putative |
Plasmodium knowlesi | PKNH_0700800 | protein RER1, putative |
Plasmodium vivax | PVX_098600 | protein RER1, putative |
Plasmodium yoelii | PY01823 | Drosophila melanogaster RE24638p |
Saccharomyces cerevisiae | YCL001W | Rer1p |
Schistosoma japonicum | Sjp_0305870 | Protein RER1, putative |
Schistosoma japonicum | Sjp_0201640 | Protein RER1, putative |
Schistosoma mansoni | Smp_019490.4 | RER1 protein |
Schistosoma mansoni | Smp_099690 | RER1 protein |
Schistosoma mansoni | Smp_019490.1 | RER1 protein |
Schmidtea mediterranea | mk4.013666.00 | Protein RER1 homolog |
Schmidtea mediterranea | mk4.002791.00 | Protein RER1 homolog |
Trypanosoma brucei gambiense | Tbg972.7.2800 | endoplasmatic reticulum retrieval protein, putative |
Trypanosoma brucei | Tb927.7.2510 | endoplasmatic reticulum retrieval protein, putative |
Trypanosoma cruzi | TcCLB.506857.100 | endoplasmatic reticulum retrieval protein, putative |
Trypanosoma cruzi | TcCLB.509209.10 | endoplasmatic reticulum retrieval protein, putative |
Toxoplasma gondii | TGME49_291300 | RER1 protein, putative |
Theileria parva | TP03_0665 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_437830 | rer1 protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.2510 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.2510 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.2510 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.7.2510 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0418300 | Plasmodium berghei | Slow | plasmo |
TGME49_291300 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.