Detailed view for LmjF.36.5910

Basic information

TDR Targets ID: 25519
Leishmania major, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.233 | Length (AA): 374 | MW (Da): 41194 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0046872   metal ion binding  
GO:0043874   acireductone synthase activity  
GO:0000287   magnesium ion binding  
GO:0019509   methionine salvage  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
71 348 1wdh (A) 4 254 29.00 0 1 0.99 -1.07
72 348 1wdh (A) 5 254 36.00 0 1 1.18 -1.11
72 348 1yns (A) 5 255 34.00 0 1 1.03904 -0.04
72 348 1yns (A) 5 255 36.00 0 1 1.06954 0.03
77 326 2g80 (A) 19 223 23.00 0 1 0.682849 0.3
78 326 2g80 (A) 20 223 32.00 0 1 0.692675 0.65

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_131070)

Species Accession Gene Product
Candida albicans CaO19.1495   potential haloacid dehalogenase-like hydrolase similar to S. cerevisiae UTR4 (YEL038W)
Candida albicans CaO19.9072   potential haloacid dehalogenase-like hydrolase similar to S. cerevisiae UTR4 (YEL038W)
Dictyostelium discoideum DDB_G0268036   2,3-diketo-5-methylthio-1-phosphopentane enolase
Drosophila melanogaster Dmel_CG12173   CG12173 gene product from transcript CG12173-RA
Homo sapiens ENSG00000145293   enolase-phosphatase 1
Leishmania braziliensis LbrM.35.6250   hypothetical protein, conserved
Leishmania donovani LdBPK_366170.1   2,3-diketo-5-methylthio-1-phosphopentane phosphatase, putative
Leishmania infantum LinJ.36.6170   hypothetical protein, conserved
Leishmania major LmjF.36.5910   hypothetical protein, conserved
Leishmania mexicana LmxM.36.5910   hypothetical protein, conserved
Mus musculus ENSMUSG00000029326   enolase-phosphatase 1
Oryza sativa 4326460   Os01g0101200
Saccharomyces cerevisiae YEL038W   putative acireductone synthase UTR4
Schmidtea mediterranea mk4.046052.00   Enolase-phosphatase E1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.36.5910 (Leishmania major), hypothetical protein, conserved
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