Detailed view for ML0897c

Basic information

TDR Targets ID: 255718
Mycobacterium leprae, PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE L PKNL (PROTEIN KINASE L) (STPK L)
Source Database / ID:  Leproma 

pI: 6.8394 | Length (AA): 400 | MW (Da): 43575 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 2

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 273 4ow8 (A) 9 282 41.00 0 1 1.2212 -0.92
3 352 5o2c (A) 143 471 26.00 0 1 1.0352 0.3
101 206 2pml (X) 143 248 29.00 0.000017 0.28 0.5133 -0.01
125 204 3vut (B) 225 308 47.00 0.0000017 0.11 0.1863 1.84

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129187)

Species Accession Gene Product
Brugia malayi Bm1_41795   Protein kinase domain containing protein
Caenorhabditis elegans CELE_ZK524.4   Protein ZK524.4
Drosophila melanogaster Dmel_CG8485   CG8485 gene product from transcript CG8485-RA
Echinococcus granulosus EgrG_000250800   serine:threonine protein kinase
Entamoeba histolytica EHI_186820   protein kinase domain containing protein
Echinococcus multilocularis EmuJ_000250800   serine:threonine protein kinase
Homo sapiens ENSG00000163788   SNF related kinase
Loa Loa (eye worm) LOAG_02411   CAMK/CAMKL/SNRK protein kinase
Mycobacterium leprae ML0897c   PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE L PKNL (PROTEIN KINASE L) (STPK L)
Mus musculus ENSMUSG00000038145   SNF related kinase
Schistosoma japonicum Sjp_0011590   ko:K08802 SNF related kinase, putative
Schistosoma mansoni Smp_068990   serine/threonine protein kinase
Schmidtea mediterranea mk4.027408.01  
Trichomonas vaginalis TVAG_305320   CAMK family protein kinase
Trichomonas vaginalis TVAG_353410   CAMK family protein kinase
Trichomonas vaginalis TVAG_120780   CAMK family protein kinase
Trichomonas vaginalis TVAG_108880   CAMK family protein kinase
Trichomonas vaginalis TVAG_401930   CAMK family protein kinase
Trichomonas vaginalis TVAG_075760   CAMK family protein kinase
Trichomonas vaginalis TVAG_128230   CAMK family protein kinase
Trichomonas vaginalis TVAG_317700   CAMK family protein kinase
Trichomonas vaginalis TVAG_009770   CAMK family protein kinase
Trichomonas vaginalis TVAG_454110   CAMK family protein kinase
Trichomonas vaginalis TVAG_262390   CAMK family protein kinase
Trichomonas vaginalis TVAG_361630   AGC family protein kinase
Trichomonas vaginalis TVAG_011150   CAMK family protein kinase
Trichomonas vaginalis TVAG_053620   CAMK family protein kinase
Trichomonas vaginalis TVAG_553400   CAMK family protein kinase
Trichomonas vaginalis TVAG_352400   CAMK family protein kinase
Trichomonas vaginalis TVAG_100670   CAMK family protein kinase
Trichomonas vaginalis TVAG_059090   CAMK family protein kinase
Trichomonas vaginalis TVAG_150140   CAMK family protein kinase
Trichomonas vaginalis TVAG_202030   CAMK family protein kinase
Trichomonas vaginalis TVAG_455150   CAMK family protein kinase
Trichomonas vaginalis TVAG_239740   CAMK family protein kinase
Trichomonas vaginalis TVAG_203770   CAMK family protein kinase
Trichomonas vaginalis TVAG_077640   CAMK family protein kinase
Trichomonas vaginalis TVAG_439830   CAMK family protein kinase
Trichomonas vaginalis TVAG_416620   CAMK family protein kinase
Trichomonas vaginalis TVAG_180370   AGC family protein kinase
Trichomonas vaginalis TVAG_423120   CAMK family protein kinase
Trichomonas vaginalis TVAG_483710   CAMK family protein kinase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens SNF related kinase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 33.1% 166 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0093 0.8828 0.5
0.0092 1 0.5
0.0039 0.9485 0.5
0.0007 0.5 0.5
0.0088 0.4477 1
0.0061 0.6883 0.6563
0.0027 1 0.5
0.0081 1 0.5
0.0042 0.5 0.5
0.0098 0.3242 0.7875
0.0064 0.3377 0.5
0.0032 0.5 0.5
0.0016 0.5 0.5
0.0012 0.5 0.5
0.0023 0.5 0.5
0.0004 0.5 0.5
0.0032 0.5 0.5
0.0012 0.5 0.5
0.0016 0.5 0.5
0.0069 0.3067 0.5
0.0029 0.5 0.5
0.0063 0.7244 0.5
0.0008 0.5 0.5
0.0056 1 0.5
0.0033 0.5 0.5
0.0081 0.5 0.5
0.0012 0.5 0.5
0.0036 0.5 0.5
0.0059 1 0.5
0.0022 0.5 0.5
0.0066 0.3101 0.5
0.0018 0.5 0.5
0.0011 1 0.5
0.0039 0.5 0.5
0.0091 1 0.5
0.0063 1 0.5
0.0039 0.5 0.5
0.0026 0.5 0.5
0.0037 1 0.5
0.0062 0.6935 0.5
0.0067 0.5 0.5
0.0059 1 0.5
0.0007 0.5 0.5
0.0007 0.5 0.5
0.0003 0.5 0.5
0.0033 1 0.5
0.0059 1 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

  • Reagent:
  • Target Type Source Notes
    ML0897c cloned gene BRENDA A gene with this EC number or name or sequence has been cloned from Mycobacterium tuberculosis ( 5 )

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier ML0897c (Mycobacterium leprae), PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE L PKNL (PROTEIN KINASE L) (STPK L)
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