Detailed view for LmjF.25.1880

Basic information

TDR Targets ID: 25572
Leishmania major, hypothetical protein, unknown function
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.0986 | Length (AA): 139 | MW (Da): 14890 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04133   Vacuolar protein sorting 55

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_128756)

Species Accession Gene Product
Arabidopsis thaliana AT3G11530   vacuolar protein sorting 55 family protein
Arabidopsis thaliana AT1G32410   vacuolar protein sorting-associated protein 55-like protein
Brugia malayi Bm1_01280   vacuolar protein sorting 55
Candida albicans CaO19.9950   one of two genes similar to S. cerevisiae VPS55 (YJR044C) involved in vacuolar protein sorting
Candida albicans CaO19.2412   one of two genes similar to S. cerevisiae VPS55 (YJR044C) involved in vacuolar protein sorting
Caenorhabditis elegans CELE_C30B5.2   Protein C30B5.2, isoform A
Dictyostelium discoideum DDB_G0280219   vacuolar protein sorting 55 family protein
Drosophila melanogaster Dmel_CG30423   CG30423 gene product from transcript CG30423-RE
Homo sapiens ENSG00000213625   leptin receptor overlapping transcript
Leishmania braziliensis LbrM.25.1440   hypothetical protein, unknown function
Leishmania donovani LdBPK_251960.1   Vacuolar protein sorting 55, putative
Leishmania infantum LinJ.25.1960   hypothetical protein, unknown function
Leishmania major LmjF.25.1880   hypothetical protein, unknown function
Leishmania mexicana LmxM.25.1880   hypothetical protein, unknown function
Loa Loa (eye worm) LOAG_02740   hypothetical protein
Mus musculus ENSMUSG00000035212   leptin receptor overlapping transcript
Mus musculus ENSMUSG00000031513   leptin receptor overlapping transcript-like 1
Mus musculus 102632213   leptin receptor gene-related protein-like
Oryza sativa 4331048   Os02g0803400
Oryza sativa 4324475   Os01g0966500
Saccharomyces cerevisiae YJR044C   Vps55p
Schistosoma japonicum Sjp_0071050   Leptin receptor overlapping transcript-like 1, putative
Schistosoma mansoni Smp_055900.4   hypothetical protein
Schistosoma mansoni Smp_055900.2   hypothetical protein
Schistosoma mansoni Smp_055900.1   hypothetical protein
Schmidtea mediterranea mk4.003084.03   Vacuolar protein sorting-associated protein 55 homolog
Trypanosoma brucei gambiense Tbg972.3.1875   hypothetical protein, unlikely
Trypanosoma brucei Tb927.3.1955   Vacuolar protein sorting-associated protein 55 homolog
Trypanosoma congolense TcIL3000_3_1050   Vacuolar protein sorting 55, putative
Trypanosoma cruzi TcCLB.504045.55   hypothetical protein, conserved

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LmjF.25.1880 (Leishmania major), hypothetical protein, unknown function
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