Detailed view for ML2211c

Basic information

TDR Targets ID: 255764
Mycobacterium leprae, PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II PURL (FGAM SYNTHASE II)
Source Database / ID:  Leproma 

pI: 4.4611 | Length (AA): 754 | MW (Da): 80099 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00586   AIR synthase related protein, N-terminal domain
PF02769   AIR synthase related protein, C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005737   cytoplasm  
GO:0004642   phosphoribosylformylglycinamidine synthase activity  
GO:0003824   catalytic activity  
GO:0006189   'de novo' IMP biosynthetic process  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 744 4lgy (A) 161 980 24.00 0 1 1.13311 0.27
19 753 3viu (A) 6 723 42.00 0 1 1.4965 -0.76

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127725)

Species Accession Gene Product
Arabidopsis thaliana AT1G74260   phosphoribosylformylglycinamidine synthase
Candida albicans CaO19.13694   5'-phosphoribosylformyl glycinamidine synthetase
Candida albicans CaO19.6317   5'-phosphoribosylformyl glycinamidine synthetase
Caenorhabditis elegans CELE_F10F2.2   Protein F10F2.2
Dictyostelium discoideum DDB_G0288145   phosphoribosylformylglycinamide synthase
Drosophila melanogaster Dmel_CG9127   adenosine 2
Escherichia coli b2557   phosphoribosylformyl-glycineamide synthetase
Homo sapiens ENSG00000178921   phosphoribosylformylglycinamidine synthase
Mycobacterium leprae ML2211c   PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II PURL (FGAM SYNTHASE II)
Mus musculus ENSMUSG00000020899   phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)
Mycobacterium tuberculosis Rv0803   Phosphoribosylformylglycinamidine synthase II PurL (FGAM synthase II)
Mycobacterium ulcerans MUL_0410   phosphoribosylformylglycinamidine synthase II
Oryza sativa 4324899   Os01g0888500
Onchocerca volvulus OVOC9735  
Saccharomyces cerevisiae YGR061C   phosphoribosylformylglycinamidine synthase
Schmidtea mediterranea mk4.058068.00  
Schmidtea mediterranea mk4.058068.01  
Schmidtea mediterranea mk4.000226.08   Probable phosphoribosylformylglycinamidine synthase
Schmidtea mediterranea mk4.000226.07  
Wolbachia endosymbiont of Brugia malayi Wbm0271   phosphoribosylformylglycinamidine synthase domain-containing protein

Essentiality

ML2211c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b2557 Escherichia coli non-essential goodall
CELE_F10F2.2 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier ML2211c (Mycobacterium leprae), PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II PURL (FGAM SYNTHASE II)
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