Detailed view for ML0424c

Basic information

TDR Targets ID: 255827
Mycobacterium leprae, Probable bacterioferritin comigratory protein Bcp
Source Database / ID:  Leproma 

pI: 6.6906 | Length (AA): 161 | MW (Da): 17531 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00578   AhpC/TSA family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  
GO:0016209   antioxidant activity  
GO:0055114   oxidation reduction  
GO:0045454   cell redox homeostasis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 161 2a4v (A) 59 209 30.00 0.0000000068 1 1.41778 -1.21
5 155 3ixr (A) 0 153 30.00 0 1 1.43789 -1.56
7 158 5enu (A) 3 153 34.00 0 1 1.5253 -1.52
101 134 4e0b (A) 130 164 50.00 0.23 0.08 0.50418 1.81

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127887)

Species Accession Gene Product
Arabidopsis thaliana AT3G26060   peroxiredoxin Q
Babesia bovis BBOV_IV005180   conserved hypothetical protein
Candida albicans CaO19.12872   similar to S. cerevisiae DOT5 (YIL010W) nuclear thioredoxin peroxidase involved in Derepression Of Telomeric silencing
Candida albicans CaO19.5417   similar to S. cerevisiae DOT5 (YIL010W) nuclear thioredoxin peroxidase involved in Derepression Of Telomeric silencing
Dictyostelium discoideum DDB_G0272280   AhpC/TSA family protein
Dictyostelium discoideum DDB_G0285273   AhpC/TSA family protein
Dictyostelium discoideum DDB_G0279973   AhpC/TSA family protein
Dictyostelium discoideum DDB_G0269392   AhpC/TSA family protein
Dictyostelium discoideum DDB_G0269270   AhpC/TSA family protein
Dictyostelium discoideum DDB_G0268192   AhpC/TSA family protein
Dictyostelium discoideum DDB_G0269256   AhpC/TSA family protein
Dictyostelium discoideum DDB_G0275755   AhpC/TSA family protein
Dictyostelium discoideum DDB_G0279949   AhpC/TSA family protein
Dictyostelium discoideum DDB_G0279951   AhpC/TSA family protein
Dictyostelium discoideum DDB_G0269260   AhpC/TSA family protein
Escherichia coli b2480   peroxiredoxin
Mycobacterium leprae ML0424c   Probable bacterioferritin comigratory protein Bcp
Mycobacterium tuberculosis Rv1608c   Probable peroxidoxin BcpB
Mycobacterium tuberculosis Rv2521   Probable bacterioferritin comigratory protein Bcp
Mycobacterium ulcerans MUL_3811   bacterioferritin comigratory protein Bcp
Mycobacterium ulcerans MUL_1588   peroxidoxin BcpB
Oryza sativa 4340391   Os06g0196300
Plasmodium berghei PBANKA_0511400   peroxiredoxin, putative
Plasmodium falciparum PF3D7_1027300   peroxiredoxin
Plasmodium knowlesi PKNH_0611700   peroxiredoxin, putative
Plasmodium vivax PVX_111355   merozoite capping protein 1, putative
Plasmodium yoelii PY03834   AhpC/TSA family, putative
Saccharomyces cerevisiae YIL010W   Dot5p
Theileria parva TP01_0224   hypothetical protein
Trichomonas vaginalis TVAG_487570   peroxiredoxins, prx-1, prx-2, prx-3, putative
Wolbachia endosymbiont of Brugia malayi Wbm0127   peroxiredoxin

Essentiality

ML0424c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu1636 Mycobacterium tuberculosis non-essential nmpdr
b2480 Escherichia coli non-essential goodall
PBANKA_0511400 Plasmodium berghei Slow plasmo
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier ML0424c (Mycobacterium leprae), Probable bacterioferritin comigratory protein Bcp
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