Detailed view for ML0102

Basic information

TDR Targets ID: 255957
Mycobacterium leprae, Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase)
Source Database / ID:  Leproma 

pI: 6.3525 | Length (AA): 517 | MW (Da): 56020 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01039   Carboxyl transferase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016874   ligase activity  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 517 2a7s (A) 20 548 45.00 0 1 1.5196 -0.11
3 517 3iav (A) 11 530 49.00 0 1 1.59723 -0.57
5 517 5ing (A) 16 532 50.00 0 1 1.55966 -0.25
5 517 1vrg (A) 2 515 47.00 0 1 1.57666 -0.42

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_208973)

Species Accession Gene Product
Mycobacterium leprae ML0102   Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase)
Mycobacterium tuberculosis Rv3799c   Probable propionyl-CoA carboxylase beta chain 4 AccD4 (pccase) (propanoyl-CoA:carbon dioxide ligase)
Mycobacterium ulcerans MUL_4982   propionyl-CoA carboxylase beta chain 4 AccD4

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) inferred from in-silico analysis (ECO:0000043) Mycobacterium tuberculosis No drug identifiers listed for this gene.
Annotator: crowther@u.washington.edu. Comment: 2007-12-07. References: 16261191

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • BRENDA Assay
  • An enzyme with this EC number or name or sequence has been assayed in Mycobacterium phlei ( 1 )

Reagent availability

  • Reagent:
  • Target Type Source Notes
    ML0102 purified protein BRENDA A protein with this EC number or name or sequence has been purified from Mycobacterium phlei ( 1 )

Bibliographic References

1 literature reference was collected for this gene.

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User comments

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Gene identifier ML0102 (Mycobacterium leprae), Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase)
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