pI: 11.7516 |
Length (AA): 138 |
MW (Da): 15806 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 136 | 1wki (A) | 1 | 136 | 56.00 | 0 | 1 | 1.61851 | 0.07 |
4 | 137 | 4wfa (J) | 4 | 137 | 56.00 | 0 | 1 | 1.67201 | -0.61 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127517)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | ArthMp008 | ribosomal protein L16 |
Arabidopsis thaliana | ArthCp060 | ribosomal protein L16 |
Arabidopsis thaliana | ArthMp009 | ribosomal protein S3 |
Babesia bovis | BBOV_V000410 | rpl16 |
Babesia bovis | BBOV_II005040 | ribosomal protein L16, putative |
Brugia malayi | Bm1_03960 | ribosomal protein L16 containing protein |
Candida albicans | CaO19.2019 | likely mitochondrial ribosomal protein similar to S. cerevisiae MRPL16 (YBL038W) large subunit protein L16 |
Candida albicans | CaO19.9569 | likely mitochondrial ribosomal protein similar to S. cerevisiae MRPL16 (YBL038W) large subunit protein L16 |
Caenorhabditis elegans | CELE_T04A8.11 | Protein MRPL-16 |
Chlamydia trachomatis | CT_521 | 50S ribosomal protein L16 |
Dictyostelium discoideum | DidioMp28 | ribosomal protein L16 |
Drosophila melanogaster | Dmel_CG3109 | mitochondrial ribosomal protein L16 |
Escherichia coli | b3313 | 50S ribosomal subunit protein L16 |
Echinococcus granulosus | EgrG_000978100 | 39S ribosomal protein L16 mitochondrial |
Echinococcus multilocularis | EmuJ_000978100 | 39S ribosomal protein L16, mitochondrial |
Homo sapiens | ENSG00000166902 | mitochondrial ribosomal protein L16 |
Loa Loa (eye worm) | LOAG_10621 | ribosomal protein L16 containing protein |
Mycobacterium leprae | ML1856c | PROBABLE 50S RIBOSOMAL PROTEIN L16 RPLP |
Mus musculus | ENSMUSG00000024683 | mitochondrial ribosomal protein L16 |
Mycobacterium tuberculosis | Rv0708 | 50S ribosomal protein L16 RplP |
Mycobacterium ulcerans | MUL_0797 | 50S ribosomal protein L16 |
Neospora caninum | NCLIV_012280 | ribosomal protein L16, putative |
Oryza sativa | 3131423 | ribosomal protein L16 |
Oryza sativa | 4352371 | Os12g0524700 |
Oryza sativa | 6450196 | ribosomal protein S3 |
Plasmodium berghei | PBANKA_API00380 | apicoplast ribosomal protein L16 |
Plasmodium berghei | PBANKA_1037700 | mitochondrial ribosomal protein L16 precursor, putative |
Plasmodium falciparum | PF3D7_1404400 | mitochondrial ribosomal protein L16 precursor, putative |
Plasmodium falciparum | PF3D7_API01800 | apicoplast ribosomal protein L16 |
Plasmodium knowlesi | PKNH_1353700 | ribosomal protein L16, putative |
Plasmodium knowlesi | PKNH_API02700 | apicoplast ribosomal protein L16, putative |
Plasmodium vivax | PVX_086215 | 50S ribosomal protein L16, putative |
Plasmodium yoelii | PY04761 | ribosomal protein L16, putative |
Plasmodium yoelii | PY00995 | ribosomal protein L16, putative |
Saccharomyces cerevisiae | YBL038W | mitochondrial 54S ribosomal protein YmL47 |
Schistosoma japonicum | Sjp_0048310 | 39S ribosomal protein L16, mitochondrial precursor, putative |
Schistosoma mansoni | Smp_154690 | ribosomal protein related |
Schmidtea mediterranea | mk4.006620.01 | 39S ribosomal protein L16, mitochondrial |
Toxoplasma gondii | TGME49_300613 | ribosomal protein L16, putative |
Toxoplasma gondii | TGME49_220150 | 50S ribosomal protein L16, putative |
Treponema pallidum | TP0196 | 50S ribosomal protein L16 |
Theileria parva | TP04_0046 | 60S ribosomal protein L16, putative |
Theileria parva | TP05_0006 | ribosomal protein L16, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0334 | 50S ribosomal protein L16 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu720 | Mycobacterium tuberculosis | essential | nmpdr |
b3313 | Escherichia coli | essential | goodall |
CELE_T04A8.11 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T04A8.11 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T04A8.11 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_1037700 | Plasmodium berghei | Essential | plasmo |
TGME49_220150 | Toxoplasma gondii | Probably essential | sidik |
TGME49_300613 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.