Detailed view for ML0854

Basic information

TDR Targets ID: 256978
Mycobacterium leprae, BIFUNCTIONAL PROTEIN POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE GPSI: GUANOSINE PENTAPHOSPHATE SYNTHETASE + POLYRIBONUCLEOTIDE NU
Source Database / ID:  Leproma 

pI: 4.5033 | Length (AA): 773 | MW (Da): 82047 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00013   KH domain
PF00575   S1 RNA binding domain
PF01138   3' exoribonuclease family, domain 1
PF03726   Polyribonucleotide nucleotidyltransferase, RNA binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005739   mitochondrion  
GO:0005737   cytoplasm  
GO:0000175   3'-5'-exoribonuclease activity  
GO:0004654   polyribonucleotide nucleotidyltransferase activity  
GO:0003723   RNA binding  
GO:0003676   nucleic acid binding  
GO:0006402   mRNA catabolic process  
GO:0006396   RNA processing  

Metabolic Pathways

Purine metabolism (KEGG)
Pyrimidine metabolism (KEGG)
RNA degradation (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 732 1e3p (A) 8 717 73.00 0 1 1.62784 0.01
597 660 2axy (A) 12 78 23.00 0 0.98 0.514094 -1.76
601 664 2p2r (A) 290 358 33.00 0 1 0.539094 -1.62
664 767 1yz6 (A) 7 112 23.00 0 0.87 0.422841 -0.36
666 765 2k4k (A) 5 105 32.00 0 1 0.493666 0

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128725)

Species Accession Gene Product
Arabidopsis thaliana AT5G14580   polyribonucleotide nucleotidyltransferase
Arabidopsis thaliana AT3G03710   polyribonucleotide nucleotidyltransferase
Brugia malayi Bm1_33025   3' exoribonuclease family, domain 2 containing protein
Caenorhabditis elegans CELE_BE0003N10.1   Protein BE0003N10.1
Chlamydia trachomatis CT_842   polyribonucleotide nucleotidyltransferase
Drosophila melanogaster Dmel_CG11337   CG11337 gene product from transcript CG11337-RD
Escherichia coli b3164   polynucleotide phosphorylase/polyadenylase
Homo sapiens ENSG00000138035   polyribonucleotide nucleotidyltransferase 1
Loa Loa (eye worm) LOAG_11043   3' exoribonuclease
Loa Loa (eye worm) LOAG_08380   hypothetical protein
Mycobacterium leprae ML0854   BIFUNCTIONAL PROTEIN POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE GPSI: GUANOSINE PENTAPHOSPHATE SYNTHETASE + POLYRIBONUCLEOTIDE NU
Mus musculus ENSMUSG00000020464   polyribonucleotide nucleotidyltransferase 1
Mycobacterium tuberculosis Rv2783c   Bifunctional protein polyribonucleotide nucleotidyltransferase GpsI: guanosine pentaphosphate synthetase + polyribonucleotide nu
Mycobacterium ulcerans MUL_2150   polynucleotide phosphorylase/polyadenylase
Oryza sativa 4342497   Os07g0168000
Schmidtea mediterranea mk4.003485.00  
Schmidtea mediterranea mk4.034460.01  
Treponema pallidum TP0886   polynucleotide phosphorylase/polyadenylase
Wolbachia endosymbiont of Brugia malayi Wbm0019   polynucleotide phosphorylase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • Assay for Polynucleotide Phosphorylase (2.7.7.8 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier ML0854 (Mycobacterium leprae), BIFUNCTIONAL PROTEIN POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE GPSI: GUANOSINE PENTAPHOSPHATE SYNTHETASE + POLYRIBONUCLEOTIDE NU
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