Detailed view for ML0697c
Basic information
Mycobacterium leprae, Probable succinate dehydrogenase (flavoprotein subunit) SdhA (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENA
Source Database / ID: Leproma
pI: 5.9972 |
Length (AA): 584 |
MW (Da): 64221 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Gene Ontology
GO:0050660 FAD binding
GO:0016491 oxidoreductase activity
GO:0055114 oxidation reduction
GO:0022900 electron transport chain
GO:0006099 tricarboxylic acid cycle
Metabolic Pathways
Oxidative phosphorylation (KEGG)
Benzoate degradation via CoA ligation (KEGG)
Butanoate metabolism (KEGG)
Reductive carboxylate cycle (CO2 fixation) (KEGG)
Global map (KEGG)
Biosynthesis of secondary metabolites (KEGG)
Microbial metabolism in diverse environments (KEGG)
Biosynthesis of antibiotics (KEGG)
Carbon metabolism (KEGG)
Structural information
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 2 | 584 | 2wdq (A) | 3 | 588 | 48.00 | 0 | 1 | 1.63439 | -1.02 |
| 2 | 584 | 2bs2 (A) | 1 | 597 | 34.00 | 0 | 1 | 1.41239 | -0.64 |
| 4 | 584 | 1zoy (A) | 17 | 614 | 46.00 | 0 | 1 | 1.56896 | -0.91 |
Help me make sense of these data.
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Expression
Orthologs
Ortholog group members (OG5_126927)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT2G18450 | succinate dehydrogenase [ubiquinone] flavoprotein subunit 2 |
| Arabidopsis thaliana | AT5G66760 | succinate dehydrogenase [ubiquinone] flavoprotein subunit 1 |
| Babesia bovis | BBOV_IV007210 | succinate dehydrogenase alpha subunit, putative |
| Brugia malayi | Bm1_17325 | succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial |
| Brugia malayi | Bm1_17330 | succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial |
| Candida albicans | CaO19.8070 | succinate dehydrogenase |
| Candida albicans | CaO19.440 | succinate dehydrogenase |
| Candida albicans | CaO19.10389 | flavoprotein subunit of succinate dehydrogenase |
| Candida albicans | CaO19.2871 | flavoprotein subunit of succinate dehydrogenase |
| Caenorhabditis elegans | CELE_C03G5.1 | Protein SDHA-1 |
| Caenorhabditis elegans | CELE_C34B2.7 | Protein SDHA-2 |
| Chlamydia trachomatis | CT_592 | succinate dehydrogenase flavoprotein subunit |
| Dictyostelium discoideum | DDB_G0280535 | complex II, flavoprotein subunit |
| Drosophila melanogaster | Dmel_CG17246 | Succinate dehydrogenase A |
| Drosophila melanogaster | Dmel_CG5718 | CG5718 gene product from transcript CG5718-RA |
| Escherichia coli | b0723 | succinate dehydrogenase, flavoprotein subunit |
| Escherichia coli | b4154 | fumarate reductase (anaerobic) catalytic and NAD/flavoprotein subunit |
| Echinococcus granulosus | EgrG_000422600 | succinate dehydrogenase ubiquinone |
| Echinococcus multilocularis | EmuJ_000422600 | succinate dehydrogenase (ubiquinone) |
| Homo sapiens | 101930534 | succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like |
| Homo sapiens | ENSG00000073578 | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) |
| Leishmania braziliensis | LbrM.24.1690 | succinate dehydrogenase flavoprotein, putative |
| Leishmania donovani | LdBPK_241700.1 | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial |
| Leishmania infantum | LinJ.24.1700 | succinate dehydrogenase flavoprotein, putative |
| Leishmania major | LmjF.24.1630 | succinate dehydrogenase flavoprotein, putative |
| Leishmania mexicana | LmxM.24.1630 | succinate dehydrogenase flavoprotein, putative |
| Loa Loa (eye worm) | LOAG_09746 | succinate-ubiquinone oxidoreductase |
| Loa Loa (eye worm) | LOAG_12615 | succinate dehydrogenase flavoprotein subunit |
| Loa Loa (eye worm) | LOAG_11674 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_11671 | succinate dehydrogenase flavoprotein subunit |
| Mycobacterium leprae | ML0697c | Probable succinate dehydrogenase (flavoprotein subunit) SdhA (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENA |
| Mus musculus | ENSMUSG00000021577 | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) |
| Mycobacterium tuberculosis | Rv0248c | Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) |
| Mycobacterium tuberculosis | Rv3318 | Probable succinate dehydrogenase (flavoprotein subunit) SdhA (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogena |
| Mycobacterium tuberculosis | Rv1552 | Probable fumarate reductase [flavoprotein subunit] FrdA (fumarate dehydrogenase) (fumaric hydrogenase) |
| Mycobacterium ulcerans | MUL_1172 | succinate dehydrogenase flavoprotein subunit |
| Mycobacterium ulcerans | MUL_1369 | succinate dehydrogenase flavoprotein subunit |
| Neospora caninum | NCLIV_068970 | Succinate dehydrogenase flavoprotein subunit, related |
| Neospora caninum | NCLIV_052500 | hypothetical protein |
| Oryza sativa | 4342350 | Os07g0134800 |
| Onchocerca volvulus | OVOC2097 | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial homolog |
| Onchocerca volvulus | OVOC2268 | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial homolog |
| Plasmodium berghei | PBANKA_0518200 | flavoprotein subunit of succinate dehydrogenase, putative |
| Plasmodium falciparum | PF3D7_1034400 | flavoprotein subunit of succinate dehydrogenase |
| Plasmodium knowlesi | PKNH_0619600 | flavoprotein subunit of succinate dehydrogenase, putative |
| Plasmodium vivax | PVX_111005 | flavoprotein subunit of succinate dehydrogenase, putative |
| Plasmodium yoelii | PY05468 | flavoprotein subunit of succinate dehydrogenase |
| Saccharomyces cerevisiae | YJL045W | succinate dehydrogenase SDH1b |
| Saccharomyces cerevisiae | YKL148C | succinate dehydrogenase flavoprotein subunit SDH1 |
| Schistosoma japonicum | Sjp_0300770 | ko:K00239 succinate dehydrogenase flavoprotein subunit, putative |
| Schistosoma mansoni | Smp_061230 | succinate dehydrogenase |
| Schmidtea mediterranea | mk4.000098.09 | Succinate dehydrogenase |
| Schmidtea mediterranea | mk4.046581.01 | Succinate dehydrogenase |
| Trypanosoma brucei gambiense | Tbg972.8.6750 | succinate dehydrogenase flavoprotein, putative |
| Trypanosoma brucei | Tb927.8.6580 | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial |
| Trypanosoma congolense | TcIL3000_8_6450 | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial |
| Trypanosoma cruzi | TcCLB.511909.40 | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial |
| Toxoplasma gondii | TGME49_215590 | flavoprotein subunit of succinate dehydrogenase |
| Theileria parva | TP03_0230 | succinate dehydrogenase flavoprotein subunit, putative |
| Wolbachia endosymbiont of Brugia malayi | Wbm0448 | succinate dehydrogenase flavoprotein subunit |
Essentiality
| Gene/Ortholog | Organism | Phenotype | Source Study |
|---|---|---|---|
| Tb927.8.6580 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
| Tb927.8.6580 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
| Tb927.8.6580 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
| Tb927.8.6580 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
| b0723 | Escherichia coli | non-essential | goodall |
| b4154 | Escherichia coli | non-essential | goodall |
| CELE_C03G5.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_C03G5.1 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_C03G5.1 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_C34B2.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_C34B2.7 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_C34B2.7 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_C34B2.7 | Caenorhabditis elegans | sterile | wormbase |
| PBANKA_0518200 | Plasmodium berghei | Dispensable | plasmo |
| TGME49_215590 | Toxoplasma gondii | Probably essential | sidik |
-
yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database -
shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan -
nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource -
gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84 -
alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924 -
keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection -
neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs -
blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930 -
wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Known modulators for this target
Predicted associations
By orthology with druggable targets
| Species | Known druggable target | Linked compounds | Reference |
|---|---|---|---|
| Plasmodium falciparum | flavoprotein subunit of succinate dehydrogenase | Compounds | References |
By sequence similarity to non orthologous druggable targets
Obtained from network model
Assayability
Assay information
- BRENDA Assay
- An enzyme with this EC number or name or sequence has been assayed in Mycobacterium phlei ( 1 )
Reagent availability
- Reagent:
-
Target Type Source Notes ML0697c purified protein BRENDA A protein with this EC number or name or sequence has been purified from Mycobacterium phlei ( 1 )
Bibliographic References