Detailed view for TGME49_249370

Basic information

TDR Targets ID: 257305
Toxoplasma gondii, translation initiation factor SUI1, putative
Source Database / ID:  ToxoDB 

pI: 9.8656 | Length (AA): 309 | MW (Da): 34684 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01253   Translation initiation factor SUI1

Gene Ontology

Mouse over links to read term descriptions.
GO:0003743   translation initiation factor activity  
GO:0006413   translational initiation  
GO:0006412   translation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
192 308 2if1 () 8 125 44.00 0 1 0.92 -0.09
222 301 1d1r (A) 29 105 30.00 0 1 0.6 -0.38
197 308 2ogh (A) 1 107 49.00 0 1 0.88526 0.21
227 298 4mo0 (A) 27 94 37.00 0 1 0.73191 -1.39

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. Gregory Hehl AB Fritz HM Sibley/Greg
Show/Hide expression data references
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Sibley/Greg ToxoDB
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
  • Gregory ToxoDB

Orthologs

Ortholog group members (OG5_127384)

Species Accession Gene Product
Arabidopsis thaliana AT5G54940   translation initiation factor SUI1 family protein
Arabidopsis thaliana AT1G54290   protein translation factor SUI1-2
Arabidopsis thaliana AT4G27130   protein translation factor SUI1-1
Arabidopsis thaliana AT5G54760   translation initiation factor SUI1 family protein
Babesia bovis BBOV_III003030   translation initiation factor SUI1, putative
Candida albicans CaO19.8867   similar to S. cerevisiae SUI1 (YNL244C)16kD subunit of translation initiation factor eIF3 which has a role in start site selecti
Candida albicans CaO19.1280   similar to S. cerevisiae SUI1 (YNL244C)16kD subunit of translation initiation factor eIF3 which has a role in start site selecti
Caenorhabditis elegans CELE_T27F7.3   Protein EIF-1
Cryptosporidium hominis Chro.20093   translation initiation factor SUI1
Cryptosporidium parvum cgd2_820   putative translation initiation factor 1 (eIF1), SUI1p
Dictyostelium discoideum DDB_G0274239   eukaryotic translation initiation factor 1
Drosophila melanogaster Dmel_CG17737   CG17737 gene product from transcript CG17737-RA
Echinococcus granulosus EgrG_000144100   protein translation factor sui1
Entamoeba histolytica EHI_179390   Translation initiation factor, putative
Echinococcus multilocularis EmuJ_000144100   protein translation factor sui1
Echinococcus multilocularis EmuJ_000140400   protein translation factor sui1
Giardia lamblia GL50803_1657   Translation initiation factor
Homo sapiens ENSG00000114784   eukaryotic translation initiation factor 1B
Homo sapiens 10209   eukaryotic translation initiation factor 1
Leishmania braziliensis LbrM.24.1230   translation factor sui1, putative
Leishmania donovani LdBPK_241240.1   Eukaryotic translation initiation factor 1, putative
Leishmania infantum LinJ.24.1240   translation factor sui1, putative
Leishmania major LmjF.24.1210   translation factor sui1, putative
Leishmania mexicana LmxM.24.1210   translation factor sui1, putative
Mus musculus ENSMUSG00000035530   eukaryotic translation initiation factor 1
Mus musculus 102633525   predicted gene, 31332
Mus musculus 102639922   predicted gene 10157
Mus musculus ENSMUSG00000006941   eukaryotic translation initiation factor 1B
Neospora caninum NCLIV_065570   translation initiation factor SUI1, putative
Neospora caninum NCLIV_014350   hypothetical protein
Oryza sativa 4339216   Os05g0498400
Oryza sativa 4324136   Os01g0794500
Oryza sativa 4343445   Os07g0529800
Oryza sativa 4337078   Os04g0627900
Plasmodium berghei PBANKA_1456900   translation initiation factor SUI1, putative
Plasmodium falciparum PF3D7_1243600   translation initiation factor SUI1, putative
Plasmodium knowlesi PKNH_1462900   translation initiation factor SUI1, putative
Plasmodium vivax PVX_101080   translation initiation factor SUI1, putative
Plasmodium yoelii PY01209   translation initiation factor SUI1
Saccharomyces cerevisiae YNL244C   translation initiation factor eIF1
Schistosoma japonicum Sjp_0002810   ko:K03113 translation initiation factor SUI1, putative
Schistosoma mansoni Smp_019440   translation factor sui1
Schmidtea mediterranea mk4.003342.03   Protein translation factor SUI1 homolog
Schmidtea mediterranea mk4.003685.02   Protein translation factor SUI1 homolog
Schmidtea mediterranea mk4.000849.00   Protein translation factor SUI1 homolog
Trypanosoma brucei gambiense Tbg972.11.6590   Protein translation factor SUI1 homolog, putative
Trypanosoma brucei Tb927.11.5840   Protein translation factor SUI1 homolog, putative
Trypanosoma congolense TcIL3000.11.6240   Eukaryotic translation initiation factor 1, putative
Trypanosoma congolense TcIL3000.11.6220   Eukaryotic translation initiation factor 1, putative
Trypanosoma cruzi TcCLB.508515.20   Eukaryotic translation initiation factor 1, putative
Trypanosoma cruzi TcCLB.508641.184   Eukaryotic translation initiation factor 1, putative
Toxoplasma gondii TGME49_249370   translation initiation factor SUI1, putative
Toxoplasma gondii TGME49_286090   translation initiation factor SUI1, putative
Theileria parva TP04_0142   protein translation initiation factor SUI1, putative
Trichomonas vaginalis TVAG_066940   translation factor sui1, putative
Trichomonas vaginalis TVAG_134990   translation factor sui1, putative

Essentiality

TGME49_249370 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.3595 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.3595 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.3595 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.3595 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T27F7.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_T27F7.3 Caenorhabditis elegans larval arrest wormbase
CELE_T27F7.3 Caenorhabditis elegans larval lethal wormbase
CELE_T27F7.3 Caenorhabditis elegans slow growth wormbase
YNL244C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1456900 Plasmodium berghei Essential plasmo
TGME49_249370 this record Toxoplasma gondii Probably non-essential sidik
TGME49_286090 Toxoplasma gondii Probably non-essential sidik
TGME49_249370 this record Toxoplasma gondii Essentiality uncertain sidik
TGME49_286090 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TGME49_249370 (Toxoplasma gondii), translation initiation factor SUI1, putative
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