Detailed view for TGME49_248320

Basic information

TDR Targets ID: 257323
Toxoplasma gondii, carrier superfamily protein
Source Database / ID:  ToxoDB 

pI: 9.8834 | Length (AA): 358 | MW (Da): 38909 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00153   Mitochondrial carrier protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005488   binding  
GO:0006810   transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile ME49 merozoite. Hehl AB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 Oocyst, ME49 Bradyzoite. Gregory Fritz HM Sibley/Greg
Show/Hide expression data references
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Gregory ToxoDB
  • Sibley/Greg ToxoDB

Orthologs

Ortholog group members (OG5_127938)

Species Accession Gene Product
Arabidopsis thaliana AT4G27940   manganese tracking factor for mitochondrial SOD2
Arabidopsis thaliana AT2G46320   mitochondrial substrate carrier family protein
Babesia bovis BBOV_II004390   mitochondrial carrier protein, putative
Brugia malayi Bm1_25200   Mitochondrial carrier C16C10.1
Candida albicans CaO19.8047   likely mitochondrial carrier protein similar to S. cerevisiae MTM1 (YGR257C) putative mitochondrial carrier protein implicated i
Candida albicans CaO19.417   likely mitochondrial carrier protein similar to S. cerevisiae MTM1 (YGR257C) putative mitochondrial carrier protein implicated i
Caenorhabditis elegans CELE_C16C10.1   Protein C16C10.1
Cryptosporidium hominis Chro.60444   mitochondrial carrier
Cryptosporidium parvum cgd6_3880   mitochondrial carrier protein MRS2 with 2 transmembrane domains
Dictyostelium discoideum DDB_G0275985   mitochondrial substrate carrier family protein
Drosophila melanogaster Dmel_CG14209   CG14209 gene product from transcript CG14209-RE
Drosophila melanogaster Dmel_CG2616   CG2616 gene product from transcript CG2616-RB
Echinococcus granulosus EgrG_000829400   solute carrier family 25 0
Echinococcus multilocularis EmuJ_000829400   solute carrier family 25 0
Homo sapiens ENSG00000075303   solute carrier family 25, member 40
Homo sapiens ENSG00000013306   solute carrier family 25, member 39
Loa Loa (eye worm) LOAG_07218   carrier protein
Mus musculus ENSMUSG00000018677   solute carrier family 25, member 39
Mus musculus ENSMUSG00000054099   solute carrier family 25, member 40
Neospora caninum NCLIV_064290   mitochondrial carrier family protein, putative
Oryza sativa 4345459   Os08g0386800
Onchocerca volvulus OVOC8036   Uncharacterized mitochondrial carrier homolog
Plasmodium berghei PBANKA_1005100   mitochondrial carrier protein, putative
Plasmodium falciparum PF3D7_0407500   mitochondrial carrier protein, putative
Plasmodium knowlesi PKNH_0305500   mitochondrial carrier protein, putative
Plasmodium vivax PVX_000870   mitochondrial carrier protein, putative
Plasmodium yoelii PY07641   Mitochondrial carrier protein, putative
Saccharomyces cerevisiae YGR257C   Mtm1p
Schistosoma japonicum Sjp_0202610   Solute carrier family 25 member 40, putative
Schistosoma mansoni Smp_137000.2   mitochondrial carrier protein
Schistosoma mansoni Smp_137000.1   mitochondrial carrier protein
Schmidtea mediterranea mk4.004790.01   Uncharacterized mitochondrial carrier
Schmidtea mediterranea mk4.013808.00   Uncharacterized mitochondrial carrier
Schmidtea mediterranea mk4.008047.04   Uncharacterized mitochondrial carrier
Toxoplasma gondii TGME49_248320   carrier superfamily protein
Theileria parva TP04_0552   hypothetical protein, conserved

Essentiality

TGME49_248320 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
CELE_C16C10.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_C16C10.1 Caenorhabditis elegans larval arrest wormbase
CELE_C16C10.1 Caenorhabditis elegans larval lethal wormbase
CELE_C16C10.1 Caenorhabditis elegans slow growth wormbase
TGME49_248320 this record Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TGME49_248320 (Toxoplasma gondii), carrier superfamily protein
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