pI: 4.9917 |
Length (AA): 145 |
MW (Da): 16977 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 143 | 1gw5 (S) | 1 | 142 | 40.00 | 0 | 1 | 1.61 | -2.17 |
1 | 145 | 1w63 (Q) | 1 | 144 | 44.00 | 0 | 1 | 1.63 | -1.75 |
1 | 145 | 4p6z (S) | 1 | 144 | 41.00 | 0 | 1 | 1.6218 | -1.4 |
1 | 144 | 4hmy (S) | 1 | 143 | 43.00 | 0 | 1 | 1.5823 | -0.72 |
1 | 143 | 2vgl (S) | 1 | 142 | 41.00 | 0 | 1 | 1.61541 | -1.32 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst. | Gregory Hehl AB Fritz HM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | ME49 Bradyzoite. | Sibley/Greg |
Sibley/Greg | ToxoDB |
Gregory | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Ortholog group members (OG5_130491)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G19790 | SNARE-like superfamily protein |
Babesia bovis | BBOV_IV010980 | clathrin assembly protein small subunit, putative |
Cryptosporidium parvum | cgd8_4900 | clathrin assembly protein, putative |
Dictyostelium discoideum | DDB_G0284905 | adapter-related protein complex 4 sigma 1 subunit |
Entamoeba histolytica | EHI_045190 | clathrin adaptor complex small chain, putative |
Homo sapiens | ENSG00000100478 | adaptor-related protein complex 4, sigma 1 subunit |
Mus musculus | ENSMUSG00000020955 | adaptor-related protein complex AP-4, sigma 1 |
Neospora caninum | NCLIV_057490 | AP-4 complex subunit sigma-1, putative |
Oryza sativa | 4345488 | Os08g0395300 |
Oryza sativa | 4348463 | Os10g0368400 |
Plasmodium berghei | PBANKA_0523500 | AP-4 complex subunit sigma, putative |
Plasmodium falciparum | PF3D7_0423100 | AP-4 complex subunit sigma, putative |
Plasmodium knowlesi | PKNH_0515000 | AP-4 complex subunit sigma, putative |
Plasmodium vivax | PVX_090195 | AP-4 complex subunit sigma, putative |
Plasmodium yoelii | PY06451 | putative clathrin assembly protein |
Trypanosoma brucei gambiense | Tbg972.10.16660 | clathrin assembly sigma-adaptin protein complex 4, putative |
Trypanosoma brucei | Tb927.10.14260 | AP-4 complex subunit sigma-1, putative |
Trypanosoma cruzi | TcCLB.506525.104 | AP-4 complex subunit sigma-1, putative |
Trypanosoma cruzi | TcCLB.511283.109 | AP-4 complex subunit sigma-1, putative |
Toxoplasma gondii | TGME49_314418 | clathrin adaptor complex small chain family protein |
Theileria parva | TP01_0763 | clathrin assembly protein, putative |
Trichomonas vaginalis | TVAG_071140 | clathrin coat assembly protein ap17, putative |
Trichomonas vaginalis | TVAG_283330 | clathrin coat assembly protein ap19, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.14260 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.14260 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.14260 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.14260 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_314418 this record | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | AP-2 complex subunit sigma | 142 aa | 41.1% | 141 aa | Compounds | References |