Detailed view for LmjF.04.0190

Basic information

TDR Targets ID: 25754
Leishmania major, surface antigen-like protein
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.736 | Length (AA): 709 | MW (Da): 73962 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: Y | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
335 513 4wnx (A) 258 462 34.00 0.011 1 0.225768 1.34
468 515 4mt2 (A) 2 46 40.00 0.76 0.89 0.536001 -0.62
581 611 1fak (L) 106 135 53.00 0.84 0.56 0.607024 -0.3
590 641 4ufr (B) 78 124 34.00 0.64 0.96 0.334643 -0.48

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_128550)

Species Accession Gene Product
Giardia lamblia GL50803_114653   VSP
Giardia lamblia GL50803_119707   VSP with INR
Giardia lamblia GL50803_15123   VSP
Giardia lamblia GL50803_112113   VSP
Giardia lamblia GL50803_137710   VSP
Giardia lamblia GL50803_15237   VSP
Giardia lamblia GL50803_101410   VSP
Giardia lamblia GL50803_113093   VSP
Giardia lamblia GL50803_10659   High cysteine membrane protein Group 1
Giardia lamblia GL50803_40571   VSP
Giardia lamblia GL50803_115085   VSP
Giardia lamblia GL50803_113954   VSP
Giardia lamblia GL50803_119706   VSP
Giardia lamblia GL50803_34357   VSP
Giardia lamblia GL50803_116477   VSP
Giardia lamblia GL50803_114122   VSP
Giardia lamblia GL50803_114121   VSP
Giardia lamblia GL50803_137620   VSP
Giardia lamblia GL50803_114674   Hypothetical protein
Giardia lamblia GL50803_14297   VSP
Giardia lamblia GL50803_103001   VSP
Giardia lamblia GL50803_111732   VSP
Giardia lamblia GL50803_114277   VSP
Giardia lamblia GL50803_33783   VSP
Giardia lamblia GL50803_114065   VSP
Giardia lamblia GL50803_137610   VSP
Leishmania infantum LinJ.04.0180   surface antigen-like protein
Leishmania major LmjF.04.0190   surface antigen-like protein
Leishmania mexicana LmxM.04.0190   surface antigen-like protein
Plasmodium vivax PVX_110960   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.04.0190 (Leishmania major), surface antigen-like protein
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