pI: 8.2432 |
Length (AA): 381 |
MW (Da): 42212 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 242 | 1xtp (A) | 19 | 254 | 39.00 | 0 | 1 | 1.41 | -0.36 |
18 | 242 | 2ex4 (A) | 0 | 224 | 34.00 | 0 | 1 | 1.24 | -0.95 |
116 | 365 | 1xtp (A) | 4 | 254 | 39.00 | 0 | 1 | 1.16827 | -0.7 |
141 | 365 | 5cvd (A) | 0 | 223 | 33.00 | 0 | 1 | 1.07845 | -0.84 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite. | Gregory Hehl AB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | ME49 Oocyst, ME49 Bradyzoite. | Fritz HM Sibley/Greg |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Gregory | ToxoDB |
Sibley/Greg | ToxoDB |
Ortholog group members (OG5_127629)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G44450 | alpha N-terminal protein methyltransferase 1 |
Brugia malayi | Bm1_20180 | Hypothetical 26.1 kDa protein in POP4-SHM1 intergenic region |
Candida albicans | CaO19_7069 | hypothetical protein |
Candida albicans | CaO19.7069 | similar to S. cerevisiae YBR261C |
Caenorhabditis elegans | CELE_Y74C9A.3 | Protein HOMT-1 |
Cryptosporidium hominis | Chro.60155 | hypothetical protein |
Cryptosporidium parvum | cgd6_1210 | hypothetical protein |
Dictyostelium discoideum | DDB_G0269658 | hypothetical protein |
Drosophila melanogaster | Dmel_CG1675 | N-terminal methyltransferase |
Echinococcus granulosus | EgrG_000411200 | alpha N terminal protein methyltransferase 1A |
Entamoeba histolytica | EHI_036850 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_000411100 | alpha N terminal protein methyltransferase 1A |
Echinococcus multilocularis | EmuJ_000410700 | nuclear pore complex protein nup214 |
Echinococcus multilocularis | EmuJ_000411200 | alpha N terminal protein methyltransferase 1A |
Giardia lamblia | GL50803_12215 | S-adenosylmethionine-dependent methyltransferase, putative |
Homo sapiens | ENSG00000148335 | N-terminal Xaa-Pro-Lys N-methyltransferase 1 |
Homo sapiens | ENSG00000203740 | methyltransferase like 11B |
Leishmania braziliensis | LbrM.30.0940 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_300880.1 | AdoMet dependent proline di-methyltransferase, putative |
Leishmania infantum | LinJ.30.0880 | hypothetical protein, conserved |
Leishmania major | LmjF.30.0810 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.29.0810 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_05539 | hypothetical protein |
Mus musculus | 240879 | methyltransferase like 11B |
Mus musculus | ENSMUSG00000026857 | N-terminal Xaa-Pro-Lys N-methyltransferase 1 |
Neospora caninum | NCLIV_023020 | Methyltransferase like 11A, related |
Oryza sativa | 4334312 | Os03g0780900 |
Saccharomyces cerevisiae | YBR261C | Tae1p |
Schistosoma japonicum | Sjp_0000060 | similar to UPF0351 protein C9orf32, putative |
Schistosoma mansoni | Smp_124220 | hypothetical protein |
Trypanosoma brucei gambiense | Tbg972.6.2090 | |
Trypanosoma brucei gambiense | Tbg972.6.2050 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.6.2330 | RGG protein |
Trypanosoma brucei | Tb927.6.2270 | AdoMet dependent proline di-methyltransferase, putative |
Trypanosoma congolense | TcIL3000_0_37880 | RGG protein |
Trypanosoma cruzi | TcCLB.503835.30 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.509049.20 | hypothetical protein, conserved |
Toxoplasma gondii | TGME49_201720 | protein c9orf32, putative |
Trichomonas vaginalis | TVAG_452370 | protein C9orf32, putative |
Trichomonas vaginalis | TVAG_127860 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_095110 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_361900 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_253130 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.2270 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.2270 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.2270 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.2270 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y74C9A.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y74C9A.3 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_Y74C9A.3 | Caenorhabditis elegans | sterile | wormbase |
TGME49_201720 this record | Toxoplasma gondii | Essentiality uncertain | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.