Detailed view for TGME49_226060

Basic information

TDR Targets ID: 257993
Toxoplasma gondii, transmembrane amino acid transporter protein
Source Database / ID:  ToxoDB 

pI: 7.4623 | Length (AA): 717 | MW (Da): 77752 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 10

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01490   Transmembrane amino acid transporter protein

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
120 437 1xme (A) 190 509 8.00 0.000043 0.01 0.52 -0.13

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile ME49 Tachyzoite, ME49 Bradyzoite. Gregory Sibley/Greg
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile VEG Tachyzoite, ME49 Oocyst. Gregory Fritz HM
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile ME49 merozoite. Hehl AB
Show/Hide expression data references
  • Gregory ToxoDB
  • Sibley/Greg ToxoDB
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.

Orthologs

Ortholog group members (OG5_128742)

Species Accession Gene Product
Candida albicans CaO19.11618   Putative membrane transporter of the AAAP family
Candida albicans CaO19.4142   Putative membrane transporter of the AAAP family
Candida albicans CaO19.11617   similar to transmembrane amino acid transporters that control amino acid flux in vacuolar-like organelles
Candida albicans CaO19.4141   similar to transmembrane amino acid transporters that control amino acid flux in vacuolar-like organelles
Drosophila melanogaster Dmel_CG13743   CG13743 gene product from transcript CG13743-RC
Giardia lamblia GL50803_95904   Amino acid transporter system N2, putative
Homo sapiens ENSG00000169507   solute carrier family 38, member 11
Leishmania braziliensis LbrM.31.0470   amino acid transporter aATP11, putative
Leishmania braziliensis LbrM.31.0440   amino acid transporter aATP11, putative
Leishmania braziliensis LbrM.31.0460   amino acid transporter aATP11, putative
Leishmania donovani LdBPK_310350.1   amino acid transporter, putative
Leishmania donovani LdBPK_310370.1   amino acid transporter aATP11, putative
Leishmania infantum LinJ.31.0350   amino acid transporter aATP11, putative
Leishmania infantum LinJ.27.2680   amino acid permease, putative
Leishmania infantum LinJ.31.0370   amino acid transporter aATP11, putative
Leishmania infantum LinJ.31.0360   amino acid transporter aATP11, putative
Leishmania major LmjF.31.0330   amino acid transporter aATP11, putative
Leishmania major LmjF.31.0350   amino acid transporter aATP11, putative
Leishmania major LmjF.31.0340   amino acid transporter aATP11, putative
Leishmania major LmjF.27.0670   amino acid permease, putative
Leishmania mexicana LmxM.27.0670   amino acid permease, putative
Leishmania mexicana LmxM.30.0350   amino acid transporter aATP11, putative
Leishmania mexicana LmxM.30.0340   amino acid transporter aATP11, putative
Leishmania mexicana LmxM.30.0330   amino acid transporter aATP11, putative
Mus musculus ENSMUSG00000061171   solute carrier family 38, member 11
Saccharomyces cerevisiae YEL064C   Avt2p
Trypanosoma cruzi TcCLB.508923.10   amino acid permease, putative
Trypanosoma cruzi TcCLB.511325.40   amino acid permease, putative
Trypanosoma cruzi TcCLB.511325.50   amino acid permease, putative
Trypanosoma cruzi TcCLB.507101.10   amino acid permease, putative
Trypanosoma cruzi TcCLB.510245.10   amino acid permease, putative
Toxoplasma gondii TGME49_226060   transmembrane amino acid transporter protein

Essentiality

TGME49_226060 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
TGME49_226060 this record Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.4

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TGME49_226060 (Toxoplasma gondii), transmembrane amino acid transporter protein
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