pI: 7.8169 |
Length (AA): 322 |
MW (Da): 35829 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
35 | 285 | 1wy5 (A) | 6 | 243 | 21.00 | 0 | 0.93 | 1.04 | -0.25 |
8 | 308 | 3vrh (A) | 3 | 293 | 32.00 | 0 | 1 | 1.24818 | 0.1 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | amastigotes, metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_127415)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G44270 | ROL5, repressor of LRX1 |
Babesia bovis | BBOV_III004480 | conserved hypothetical protein |
Babesia bovis | BBOV_III004460 | PP-loop family protein |
Babesia bovis | BBOV_III004500 | conserved hypothetical protein |
Brugia malayi | Bm1_38855 | n-type ATP pyrophosphatase-like |
Candida albicans | CaO19.4634 | similar to S. cerevisiae YGL211W |
Candida albicans | CaO19.12104 | similar to S. cerevisiae YGL211W |
Caenorhabditis elegans | CELE_F29C4.6 | Protein TUT-1 |
Cryptosporidium hominis | Chro.50341 | cancer-associated gene protein like (41.3 kD) (4A872) |
Cryptosporidium parvum | cgd5_520 | MJ1157-like thiouridine synthase (Pploop atpase) plus Zn ribbon. involved in RNA metabolism. |
Dictyostelium discoideum | DDB_G0282921 | ATP-binding domain-containing protein 3 |
Drosophila melanogaster | Dmel_CG8078 | CG8078 gene product from transcript CG8078-RA |
Echinococcus granulosus | EgrG_000963000 | cytoplasmic tRNA 2 thiolation protein 1 |
Entamoeba histolytica | EHI_108760 | PP-loop family protein |
Echinococcus multilocularis | EmuJ_000963000 | cytoplasmic tRNA 2 thiolation protein 1 |
Giardia lamblia | GL50803_11449 | ATPase of the PP-loop superfamily implicated in cell cycle control, putative |
Homo sapiens | ENSG00000142544 | cytosolic thiouridylase subunit 1 |
Leishmania braziliensis | LbrM.35.6430 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_366380.1 | TIGR00269 family protein, putative |
Leishmania major | LmjF.36.6120 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.36.6120 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_00156 | tRNA 2-thiolation protein 1 |
Mus musculus | ENSMUSG00000038888 | cytosolic thiouridylase subunit 1 homolog (S. pombe) |
Neospora caninum | NCLIV_053470 | PP-loop domain protein, related |
Oryza sativa | 4330815 | Os02g0762300 |
Oryza sativa | 9269998 | Os01g0598900 |
Plasmodium berghei | PBANKA_0110900 | cytoplasmic tRNA 2-thiolation protein 1, putative |
Plasmodium falciparum | PF3D7_0612600 | cytoplasmic tRNA 2-thiolation protein 1, putative |
Plasmodium knowlesi | PKNH_1137400 | cytoplasmic tRNA 2-thiolation protein 1, putative |
Plasmodium vivax | PVX_113770 | hypothetical protein, conserved |
Plasmodium yoelii | PY03101 | Uncharacterized protein family UPF0021 |
Saccharomyces cerevisiae | YGL211W | Ncs6p |
Schistosoma japonicum | Sjp_0035810 | Protein NCS6, putative |
Schistosoma mansoni | Smp_040560 | cancer-associatedprotein protein |
Schmidtea mediterranea | mk4.004114.01 | Cytoplasmic tRNA 2-thiolation protein 1 |
Schmidtea mediterranea | mk4.004114.00 | Cytoplasmic tRNA 2-thiolation protein 1 |
Schmidtea mediterranea | mk4.004114.02 | |
Trypanosoma brucei gambiense | Tbg972.10.10540 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.10.8690 | TIGR00269 family protein, putative |
Trypanosoma congolense | TcIL3000_10_7480 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.508727.30 | TIGR00269 family protein, putative |
Trypanosoma cruzi | TcCLB.503797.10 | TIGR00269 family protein, putative |
Toxoplasma gondii | TGME49_309020 | PP-loop family protein |
Theileria parva | TP02_0798 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_494120 | cell cycle protein mesj, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.8690 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.8690 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.8690 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.8690 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_309020 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.