pI: 5.8195 |
Length (AA): 259 |
MW (Da): 27483 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 257 | 4nml (A) | 1 | 257 | 99.99 | 0 | 1 | 2.20788 | -1.51 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | ME49 merozoite. | Hehl AB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | ME49 Tachyzoite. | Gregory |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | VEG Tachyzoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Fritz HM Sibley/Greg |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Sibley/Greg | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Gregory | ToxoDB |
Ortholog group members (OG5_127414)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G01290 | ribose 5-phosphate isomerase A |
Arabidopsis thaliana | AT3G04790 | ribose 5-phosphate isomerase A |
Arabidopsis thaliana | AT1G71100 | ribose 5-phosphate isomerase A |
Babesia bovis | BBOV_III002460 | ribose 5-phosphate isomerase A family protein |
Brugia malayi | Bm1_57600 | ribose 5-phosphate isomerase |
Candida albicans | CaO19.1701 | similar to S. cerevisiae RKI1 (YOR095C) pentose phosphate shunt enzyme ribose-5-phosphate ketol-isomerase |
Candida albicans | CaO19.9268 | similar to S. cerevisiae RKI1 (YOR095C) pentose phosphate shunt enzyme ribose-5-phosphate ketol-isomerase |
Caenorhabditis elegans | CELE_B0280.3 | Protein RPIA-1 |
Chlamydia trachomatis | CT_213 | ribose-5-phosphate isomerase A |
Dictyostelium discoideum | DDB_G0276711 | ribose-5-phosphate isomerase |
Drosophila melanogaster | Dmel_CG30410 | Ribose-5-phosphate isomerase |
Escherichia coli | b2914 | ribose 5-phosphate isomerase, constitutive |
Echinococcus granulosus | EgrG_001185200 | integrator complex subunit 2 |
Echinococcus granulosus | EgrG_001185300 | ribose 5 phosphate isomerase |
Echinococcus multilocularis | EmuJ_001185300 | ribose 5 phosphate isomerase |
Echinococcus multilocularis | EmuJ_001185200 | integrator complex subunit 2 |
Homo sapiens | ENSG00000153574 | ribose 5-phosphate isomerase A |
Loa Loa (eye worm) | LOAG_04787 | hypothetical protein |
Loa Loa (eye worm) | LOAG_03696 | ribose 5-phosphate isomerase |
Mus musculus | ENSMUSG00000053604 | ribose 5-phosphate isomerase A |
Neospora caninum | NCLIV_015970 | Ribose 5-phosphate isomerase A (EC 5.3.1.6), related |
Oryza sativa | 4342543 | Os07g0176900 |
Oryza sativa | 4335430 | Os04g0306400 |
Plasmodium berghei | PBANKA_1114200 | ribose-5-phosphate isomerase, putative |
Plasmodium falciparum | PF3D7_0514600 | ribose-5-phosphate isomerase, putative |
Plasmodium knowlesi | PKNH_1018500 | ribose-5-phosphate isomerase, putative |
Plasmodium vivax | PVX_080515 | ribose 5-phosphate epimerase, putative |
Plasmodium yoelii | PY07185 | ribose 5-phosphate isomerase |
Saccharomyces cerevisiae | YOR095C | ribose-5-phosphate isomerase RKI1 |
Schistosoma japonicum | Sjp_0214860 | ko:K01807 ribose 5-phosphate isomerase A [EC5.3.1.6A], putative |
Schistosoma japonicum | Sjp_0012910 | Integrator complex subunit 2, putative |
Schistosoma japonicum | Sjp_0134990 | Ribose-5-phosphate isomerase, putative |
Schistosoma mansoni | Smp_148770 | ribose-5-phosphate isomerase |
Schmidtea mediterranea | mk4.029320.00 | |
Toxoplasma gondii | TGME49_239310 | ribulose 5-phosphate isomerase |
Treponema pallidum | TP0616 | ribose-5-phosphate isomerase A |
Theileria parva | TP03_0628 | ribose 5-phosphate epimerase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
YOR095C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1114200 | Plasmodium berghei | Essential | plasmo |
TGME49_239310 this record | Toxoplasma gondii | Essentiality uncertain | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.