Detailed view for TGME49_232250

Basic information

TDR Targets ID: 258569
Toxoplasma gondii, catalase
Source Database / ID:  ToxoDB 

pI: 7.1638 | Length (AA): 502 | MW (Da): 57298 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00199   Catalase
PF06628   Catalase-related immune-responsive

Gene Ontology

Mouse over links to read term descriptions.
GO:0020037   heme binding  
GO:0005506   iron ion binding  
GO:0004096   catalase activity  
GO:0055114   oxidation reduction  
GO:0006979   response to oxidative stress  

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 490 4blc (A) 11 496 62.00 0 1 1.74 -0.54
2 500 2iuf (A) 3 508 34.00 0 1 1.35 -0.34
14 490 1si8 (A) 4 474 56.00 0 1 1.67 -0.81
1 490 1dgf (A) 12 497 60.00 0 1 1.7408 -0.71
14 490 1qwl (A) 6 483 55.00 0 1 1.6158 -0.74
14 490 1si8 (A) 4 474 56.00 0 1 1.6599 -0.66

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. Gregory Hehl AB Fritz HM Sibley/Greg
Show/Hide expression data references
  • Hehl AB Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.
  • Sibley/Greg ToxoDB
  • Gregory ToxoDB
  • Fritz HM Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts.

Orthologs

Ortholog group members (OG5_127182)

Species Accession Gene Product
Arabidopsis thaliana AT1G20630   catalase 1
Arabidopsis thaliana AT1G20620   catalase 3
Arabidopsis thaliana AT4G35090   catalase 2
Candida albicans CaO19.6229   Catalase A
Candida albicans CaO19.13609   Catalase A
Caenorhabditis elegans CELE_Y54G11A.5   Protein CTL-2
Caenorhabditis elegans CELE_Y54G11A.13   Protein CTL-3
Caenorhabditis elegans CELE_Y54G11A.6   Protein CTL-1
Dictyostelium discoideum DDB_G0274595   hypothetical protein
Dictyostelium discoideum DDB_G0269108   hypothetical protein
Drosophila melanogaster Dmel_CG6871   Catalase
Drosophila melanogaster Dmel_CG9314   CG9314 gene product from transcript CG9314-RC
Escherichia coli b1732   catalase HPII, heme d-containing
Homo sapiens ENSG00000121691   catalase
Mus musculus ENSMUSG00000027187   catalase
Mycobacterium ulcerans MUL_4291   catalase KatE
Neospora caninum NCLIV_032240   Catalase (EC 1.11.1.6), related
Oryza sativa 4328073   Os02g0115700
Oryza sativa 4342124   Os06g0727200
Oryza sativa 4331509   Os03g0131200
Saccharomyces cerevisiae YDR256C   catalase A
Saccharomyces cerevisiae YGR088W   catalase T
Schmidtea mediterranea mk4.014182.03  
Schmidtea mediterranea mk4.004415.03   CG9314 protein
Schmidtea mediterranea mk4.004415.02   Catalase
Schmidtea mediterranea mk4.013112.00   CG9314 protein
Schmidtea mediterranea mk4.004415.04   CG9314 protein
Toxoplasma gondii TGME49_232250   catalase

Essentiality

TGME49_232250 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
b1732 Escherichia coli non-essential goodall
TGME49_232250 this record Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.2

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens catalase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TGME49_232250 (Toxoplasma gondii), catalase
Title for this comment
Comment