pI: 11.4594 |
Length (AA): 274 |
MW (Da): 32011 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 9 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
10 | 179 | 1cvj (A) | 27 | 179 | 20.00 | 0 | 1 | 0.76 | 0.41 |
63 | 209 | 1n52 (B) | 6 | 146 | 26.00 | 0 | 1 | 0.8 | 0.28 |
91 | 211 | 2f9d (A) | 12 | 125 | 18.00 | 0 | 0.81 | 0.55 | -0.04 |
99 | 171 | 1h2v (Z) | 41 | 114 | 32.00 | 0.0000077 | 1 | 0.84 | -1.83 |
30 | 177 | 3pgw (S) | 34 | 183 | 53.00 | 0 | 1 | 1.10755 | 0.32 |
99 | 274 | 4wik (A) | 372 | 528 | 19.00 | 0 | 1 | 0.838836 | -0.56 |
100 | 154 | 1wel (A) | 432 | 487 | 29.00 | 0.1 | 1 | 0.71413 | -1.44 |
140 | 195 | 4pkd (B) | 211 | 266 | 75.00 | 0 | 1 | 1.03188 | -0.07 |
227 | 272 | 5hmo (A) | 812 | 860 | 35.00 | 0.23 | 0.02 | 0.876283 | -4.27 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Bradyzoite. | Gregory Hehl AB Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | ME49 Oocyst. | Fritz HM |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Sibley/Greg | ToxoDB |
Ortholog group members (OG5_128070)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G50670 | U1 small nuclear ribonucleoprotein-70K |
Babesia bovis | BBOV_II005790 | u1 snRNP, putative |
Brugia malayi | Bm1_26575 | RNA binding protein |
Candida albicans | CaO19.6866 | similar to U1snRNP 70kd |
Candida albicans | CaO19.14156 | similar to U1snRNP 70kd |
Caenorhabditis elegans | CELE_K04G7.10 | Protein RNP-7 |
Cryptosporidium hominis | Chro.60129 | U1 small nuclear ribonucleoprotein |
Cryptosporidium parvum | cgd6_990 | U1 snrp Snp1p. RRM domain containing protein |
Dictyostelium discoideum | DDB_G0268004 | U1 small nuclear ribonucleoprotein 70 kDa protein |
Drosophila melanogaster | Dmel_CG8749 | small ribonucleoprotein particle U1 subunit 70K |
Echinococcus granulosus | EgrG_001019100 | RNA recognition motif RNP 1 |
Entamoeba histolytica | EHI_153670 | U1 small nuclear ribonucleoprotein subunit, putative |
Echinococcus multilocularis | EmuJ_001019100 | RNA recognition motif, RNP 1 |
Homo sapiens | ENSG00000104852 | small nuclear ribonucleoprotein 70kDa (U1) |
Leishmania braziliensis | LbrM.16.1650 | U1 small nuclear ribonucleoprotein, putative |
Leishmania donovani | LdBPK_161690.1 | u1 small nuclear ribonucleoprotein 70 kDa |
Leishmania infantum | LinJ.16.1690 | U1 small nuclear ribonucleoprotein, putative |
Leishmania major | LmjF.16.1590 | U1 small nuclear ribonucleoprotein, putative |
Leishmania mexicana | LmxM.16.1590 | U1 small nuclear ribonucleoprotein, putative |
Loa Loa (eye worm) | LOAG_10208 | hypothetical protein |
Mus musculus | ENSMUSG00000063511 | small nuclear ribonucleoprotein 70 (U1) |
Neospora caninum | NCLIV_020480 | hypothetical protein |
Oryza sativa | 4347985 | Os10g0115600 |
Plasmodium berghei | PBANKA_1143000 | U1 small nuclear ribonucleoprotein, putative |
Plasmodium falciparum | PF3D7_1367100 | U1 small nuclear ribonucleoprotein, putative |
Plasmodium knowlesi | PKNH_1104100 | U1 small nuclear ribonucleoprotein, putative |
Plasmodium vivax | PVX_115315 | U1 small nuclear ribonucleoprotein 70 kDa, putative |
Plasmodium yoelii | PY00080 | u1 small nuclear ribonucleoprotein 70 kDa |
Saccharomyces cerevisiae | YIL061C | Snp1p |
Schistosoma japonicum | Sjp_0212780 | similar to U1 small nuclear ribonucleoprotein 70 kDa, putative |
Schistosoma japonicum | Sjp_0128520 | similar to U1 small nuclear ribonucleoprotein 70 kDa, putative |
Schistosoma japonicum | Sjp_0069350 | similar to U1 small nuclear ribonucleoprotein 70 kDa, putative |
Schistosoma mansoni | Smp_013360 | U1 small nuclear ribonucleoprotein 70 kD |
Schmidtea mediterranea | mk4.002786.01 | U1 small nuclear ribonucleoprotein 70 kDa |
Trypanosoma brucei gambiense | Tbg972.8.4640 | U1 small nuclear ribonucleoprotein, putative |
Trypanosoma brucei | Tb927.8.4830 | u1 small nuclear ribonucleoprotein 70 kDa |
Trypanosoma congolense | TcIL3000_8_4530 | u1 small nuclear ribonucleoprotein 70 kDa |
Trypanosoma cruzi | TcCLB.508837.140 | u1 small nuclear ribonucleoprotein 70 kDa |
Trypanosoma cruzi | TcCLB.511383.30 | u1 small nuclear ribonucleoprotein 70 kDa |
Toxoplasma gondii | TGME49_205180 | RNA recognition motif-containing protein |
Theileria parva | TP02_0544 | U1 small nuclear ribonucleoprotein, putative |
Trichomonas vaginalis | TVAG_371310 | U1 small nuclear ribonucleoprotein 70 kD, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.4830 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.4830 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.4830 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.8.4830 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_K04G7.10 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_K04G7.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K04G7.10 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_K04G7.10 | Caenorhabditis elegans | slow growth | wormbase |
CELE_K04G7.10 | Caenorhabditis elegans | sterile | wormbase |
YIL061C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1143000 | Plasmodium berghei | Essential | plasmo |
TGME49_205180 this record | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.