pI: 6.1159 |
Length (AA): 350 |
MW (Da): 40760 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
193 | 312 | 3mqz (A) | 90 | 207 | 28.00 | 0.31 | 0.34 | 0.570957 | -0.01 |
250 | 344 | 2oc6 (A) | 26 | 114 | 28.00 | 0.3 | 0.18 | 0.409529 | 0.63 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Hehl AB Fritz HM Sibley/Greg |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Sibley/Greg | ToxoDB |
Ortholog group members (OG5_127371)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G13610 | hypothetical protein |
Arabidopsis thaliana | AT1G69380 | hypothetical protein |
Brugia malayi | Bm1_12970 | Uncharacterized ACR, YagE family COG1723 containing protein |
Candida albicans | CaO19.1617 | similar to S. cerevisiae YDR282C |
Candida albicans | CaO19.9184 | similar to S. cerevisiae YDR282C |
Candida albicans | CaO19.3158 | similar to S. cerevisiae gene Required for Meiotic Division |
Candida albicans | CaO19.10667 | similar to S. cerevisiae gene Required for Meiotic Division |
Caenorhabditis elegans | CELE_ZK1010.2 | Protein ZK1010.2 |
Cryptosporidium hominis | Chro.40468 | hypothetical protein |
Cryptosporidium parvum | cgd4_4110 | hypothetical conserved protein, possible transmembrane domain near C-terminus |
Chlamydia trachomatis | CT_472 | hypothetical protein |
Dictyostelium discoideum | DDB_G0287989 | hypothetical protein |
Drosophila melanogaster | Dmel_CG11679 | CG11679 gene product from transcript CG11679-RA |
Echinococcus granulosus | EgrG_000718100 | required for meiotic nuclear division protein 1 |
Echinococcus multilocularis | EmuJ_000718100 | required for meiotic nuclear division protein 1 |
Homo sapiens | ENSG00000155906 | required for meiotic nuclear division 1 homolog (S. cerevisiae) |
Leishmania braziliensis | LbrM.13.0930 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_131030.1 | Uncharacterised ACR, YagE family COG1723, putative |
Leishmania infantum | LinJ.13.1030 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.13.1130 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_14233 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14991 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15279 | hypothetical protein |
Mus musculus | 66084 | required for meiotic nuclear division 1 homolog (S. cerevisiae) |
Neospora caninum | NCLIV_037720 | Os07g0694800 protein, related |
Oryza sativa | 4326888 | Os01g0764300 |
Oryza sativa | 4344398 | Os07g0694800 |
Onchocerca volvulus | OVOC9484 | Required for meiotic nuclear division protein 1 homolog |
Plasmodium berghei | PBANKA_0711300 | conserved protein, unknown function |
Plasmodium falciparum | PF3D7_0819500 | conserved protein, unknown function |
Plasmodium knowlesi | PKNH_1313300 | conserved protein, unknown function |
Plasmodium vivax | PVX_089390 | hypothetical protein, conserved |
Plasmodium yoelii | PY03075 | unknown-related |
Saccharomyces cerevisiae | YDR282C | hypothetical protein |
Saccharomyces cerevisiae | YDL001W | Rmd1p |
Schistosoma japonicum | Sjp_0027160 | similar to Uncharacterized protein YDR282C, putative |
Schistosoma mansoni | Smp_084860 | hypothetical protein |
Schmidtea mediterranea | mk4.029200.00 | |
Schmidtea mediterranea | mk4.004589.00 | |
Schmidtea mediterranea | mk4.037186.00 | |
Trypanosoma brucei gambiense | Tbg972.11.4230 | hypothetical protein, conserved |
Trypanosoma brucei | Tb427tmp.02.1180 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.11.3700 | Uncharacterised ACR, YagE family COG1723, putative, unspecified product |
Trypanosoma congolense | TcIL3000_0_36840 | Uncharacterised ACR, YagE family COG1723, putative |
Trypanosoma congolense | TcIL3000.11.3650 | Uncharacterised ACR, YagE family COG1723, putative |
Trypanosoma cruzi | TcCLB.503821.5 | Uncharacterised ACR, YagE family COG1723, putative |
Trypanosoma cruzi | TcCLB.508731.9 | Uncharacterised ACR, YagE family COG1723, putative |
Trypanosoma cruzi | TcCLB.509683.30 | Uncharacterised ACR, YagE family COG1723, putative |
Toxoplasma gondii | TGME49_268630 | YagE family protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.1180 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.1180 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.1180 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.1180 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0711300 | Plasmodium berghei | Dispensable | plasmo |
TGME49_268630 this record | Toxoplasma gondii | Probably non-essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.