pI: 5.8071 |
Length (AA): 1386 |
MW (Da): 150782 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 8 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
538 | 1385 | 1u6g (C) | 14 | 1030 | 11.00 | 0 | 1 | 0.4 | -0.79 |
809 | 1278 | 1jdh (A) | 153 | 663 | 13.00 | 0 | 0.99 | 0.62 | -1.62 |
291 | 432 | 4ph8 (A) | 11 | 147 | 18.00 | 0 | 0.02 | 0.222453 | -0.09 |
319 | 513 | 4wj3 (A) | 109 | 307 | 29.00 | 0.28 | 0.79 | 0.300093 | 0.97 |
432 | 477 | 2fho (A) | 379 | 423 | 58.00 | 0.0000044 | 0.13 | 0.497589 | 0.96 |
547 | 1386 | 5ife (C) | 466 | 1304 | 71.00 | 0 | 1 | 1.46706 | -1.03 |
563 | 1261 | 1u6g (C) | 35 | 816 | 13.00 | 0 | 1 | 0.622329 | 0.22 |
931 | 1125 | 4db6 (A) | 13 | 207 | 16.00 | 0 | 1 | 0.508693 | -1.53 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | ME49 merozoite, ME49 Bradyzoite. | Hehl AB Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 Oocyst. | Gregory Fritz HM |
Gregory | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Sibley/Greg | ToxoDB |
Ortholog group members (OG5_127822)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G64270 | putative splicing factor |
Babesia bovis | BBOV_IV006950 | splicing factor, putative |
Brugia malayi | Bm1_54945 | Splicing factor 3B subunit 1 |
Candida albicans | CaO19.10190 | similar to hSF3B1/SAP155 spliceosomal U2 snRNP protein |
Candida albicans | CaO19.2675 | similar to hSF3B1/SAP155 spliceosomal U2 snRNP protein |
Caenorhabditis elegans | CELE_T08A11.2 | Protein T08A11.2 |
Cryptosporidium hominis | Chro.60546 | splicing factor |
Cryptosporidium parvum | cgd6_4750 | splicing factor 3B subunit1-like HEAT repeat containing protein |
Dictyostelium discoideum | DDB_G0275957 | HEAT repeat-containing protein |
Drosophila melanogaster | Dmel_CG2807 | CG2807 gene product from transcript CG2807-RB |
Echinococcus granulosus | EgrG_000968600 | splicing factor 3b subunit 1 |
Entamoeba histolytica | EHI_085470 | splicing factor3B subunit 1, putative |
Entamoeba histolytica | EHI_049170 | splicing factor 3B subunit 1, putative |
Echinococcus multilocularis | EmuJ_000968600 | splicing factor 3b subunit 1 |
Homo sapiens | ENSG00000115524 | splicing factor 3b, subunit 1, 155kDa |
Leishmania braziliensis | LbrM.28.2790 | splicing factor 3B subunit 1, putative |
Leishmania donovani | LdBPK_282780.1 | splicing factor 3B subunit 1, putative |
Leishmania infantum | LinJ.28.2780 | splicing factor 3B subunit 1, putative |
Leishmania major | LmjF.28.2570 | splicing factor 3B subunit 1, putative |
Leishmania mexicana | LmxM.28.2570 | splicing factor 3B subunit 1, putative |
Loa Loa (eye worm) | LOAG_04581 | hypothetical protein |
Mus musculus | ENSMUSG00000025982 | splicing factor 3b, subunit 1 |
Neospora caninum | NCLIV_020650 | splicing factor 3B subunit 1, putative |
Oryza sativa | 4328284 | Os02g0146400 |
Oryza sativa | 4328291 | Os02g0147300 |
Oryza sativa | 9272713 | Os02g0478900 |
Oryza sativa | 4328270 | Os02g0142300 |
Onchocerca volvulus | OVOC9429 | Splicing factor 3B subunit 1 homolog |
Plasmodium berghei | PBANKA_0407100 | splicing factor 3B subunit 1, putative |
Plasmodium falciparum | PF3D7_0308900 | splicing factor 3B subunit 1, putative |
Plasmodium knowlesi | PKNH_0833800 | splicing factor 3B subunit 1, putative |
Plasmodium vivax | PVX_119560 | splicing factor 3B subunit 1, putative |
Plasmodium yoelii | PY02341 | hypothetical protein |
Saccharomyces cerevisiae | YMR288W | Hsh155p |
Schistosoma japonicum | Sjp_0006680 | Splicing factor 3B subunit 1, putative |
Schistosoma mansoni | Smp_141630.2 | splicing factor 3b subunit 1-related |
Schistosoma mansoni | Smp_141630.1 | splicing factor 3b subunit 1-related |
Schistosoma mansoni | Smp_141630.4 | splicing factor 3b subunit 1-related |
Schmidtea mediterranea | mk4.000576.02 | |
Schmidtea mediterranea | mk4.001289.05 | Splicing factor 3b subunit 1 |
Trypanosoma brucei gambiense | Tbg972.11.13310 | splicing factor 3B subunit 1, putative |
Trypanosoma brucei | Tb927.11.11850 | splicing factor 3B subunit 1, putative |
Trypanosoma congolense | TcIL3000.11.12520 | splicing factor 3B subunit 1, putative |
Trypanosoma cruzi | TcCLB.508827.100 | splicing factor 3B subunit 1, putative |
Toxoplasma gondii | TGME49_205010 | U2 small nuclear ribonucleoprotein family protein, putative |
Theileria parva | TP03_0212 | splicing factor 3B subunit 1, putative |
Trichomonas vaginalis | TVAG_332520 | U2 snRNP component prp10, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.3690 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.3690 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.3690 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.3690 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T08A11.2 | Caenorhabditis elegans | adult lethal | wormbase |
CELE_T08A11.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T08A11.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T08A11.2 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_T08A11.2 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T08A11.2 | Caenorhabditis elegans | sterile | wormbase |
YMR288W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0407100 | Plasmodium berghei | Essential | plasmo |
TGME49_205010 this record | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.